DegronMD

Uniprot ID: Q5QJE6

Source protein: Deoxynucleotidyltransferase terminal-interacting protein 2

Source gene: DNTTIP2

Class: DEG_SCF_FBW7_2

Location: 608:614

E3 ligase: FBXW7

DEGRON score: 0.9898

ASA_SCORE: 71.4429

COIL: 0.5661

CONS_SCORE: 0.5329

DSS_SCORE: 0.3831

HELIX: 0.3463

FCONS_SCORE: 1.0255

RIG_SCORE: 0.7622

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.I609V	TCGA-LN-A5U6	ESCA	TCGA	VITPDFE	DEG_SCF_FBW7_2	0.5965
p.V608I	DO233731	GACA	ICGC	VITPDFE	DEG_SCF_FBW7_2	0.5965
p.V608I	DO233885	GACA	ICGC	VITPDFE	DEG_SCF_FBW7_2	0.5965
p.V608I	DO51130	PRAD	ICGC	VITPDFE	DEG_SCF_FBW7_2	0.5965
p.V608I	ACH-001960	Bile Duct Cancer	CCLE	VITPDFE	DEG_SCF_FBW7_2	0.5965
p.K599N	SIDM00628	Breast Carcinoma	GDSC	VITPDFE	DEG_SCF_FBW7_2	0.1944
p.K599N	ACH-000849	Breast Cancer	CCLE	VITPDFE	DEG_SCF_FBW7_2	0.1944
p.K599N	MDA-MB-468	breast	COSMIC	VITPDFE	DEG_SCF_FBW7_2	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5QJE6	Deoxynucleotidyltransferase terminal-interacting protein 2	DEG_SCF_FBW7_2	608:614	VITPDFE	FBXW7	0.9898	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons