DegronMD

Uniprot ID: Q5QJE6

Source protein: Deoxynucleotidyltransferase terminal-interacting protein 2

Source gene: DNTTIP2

Class: DEG_SCF_FBW7_2

Location: 126:133

E3 ligase: FBXW7

DEGRON score: 0.9974

ASA_SCORE: 113.1125

COIL: 0.9244

CONS_SCORE: 0.3486

DSS_SCORE: 0.4923

HELIX: 0.0494

FCONS_SCORE: 0.8886

RIG_SCORE: 0.7048

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R123M	TCGA-D3-A1Q1	SKCM	TCGA	PKVTPTKE	DEG_SCF_FBW7_2	0.25
p.R123M	DO37445	SKCM	ICGC	PKVTPTKE	DEG_SCF_FBW7_2	0.25
p.K132N	TCGA-ER-A2NH	SKCM	TCGA	PKVTPTKE	DEG_SCF_FBW7_2	0.5806
p.K132N	DO47683	SKCM	ICGC	PKVTPTKE	DEG_SCF_FBW7_2	0.5806

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P49418	Amphiphysin	DEG_SCF_FBW7_2	307:314	PKVTPTKE	FBXW7	0.9961	More...
Q5QJE6	Deoxynucleotidyltransferase terminal-interacting protein 2	DEG_SCF_FBW7_2	126:133	PKVTPTKE	FBXW7	0.9974	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons