DegronMD

Uniprot ID: P49418

Source protein: Amphiphysin

Source gene: AMPH

Class: DEG_SCF_FBW7_2

Location: 307:314

E3 ligase: FBXW7

DEGRON score: 0.9961

ASA_SCORE: 101.0625

COIL: 0.872

CONS_SCORE: 0.35

DSS_SCORE: 0.6475

HELIX: 0.0863

FCONS_SCORE: 1.0299

RIG_SCORE: 0.707

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q317K	TCGA-05-4382	LUAD	TCGA	PKVTPTKE	DEG_SCF_FBW7_2	0.25
p.Q317K	DO24900	LUAD	ICGC	PKVTPTKE	DEG_SCF_FBW7_2	0.25
p.K308N	TCGA-22-1005	LUSC	TCGA	PKVTPTKE	DEG_SCF_FBW7_2	0.5806
p.K308N	DO26632	LUSC	ICGC	PKVTPTKE	DEG_SCF_FBW7_2	0.5806
p.G300R	TCGA-90-A4ED	LUSC	TCGA	PKVTPTKE	DEG_SCF_FBW7_2	0.1389
p.G300R	DO45482	LUSC	ICGC	PKVTPTKE	DEG_SCF_FBW7_2	0.1389
p.K313N	TCGA-A5-A0GP	UCEC	TCGA	PKVTPTKE	DEG_SCF_FBW7_2	0.5806
p.K313N	DO41109	UCEC	ICGC	PKVTPTKE	DEG_SCF_FBW7_2	0.5806
p.I320N	TCGA-G3-AAV3	LIHC	TCGA	PKVTPTKE	DEG_SCF_FBW7_2	0.1667
p.I320N	DO52297	LIHC	ICGC	PKVTPTKE	DEG_SCF_FBW7_2	0.1667
p.P304S	TCGA-GN-A266	SKCM	TCGA	PKVTPTKE	DEG_SCF_FBW7_2	0.25
p.P304S	DO37432	SKCM	ICGC	PKVTPTKE	DEG_SCF_FBW7_2	0.25
p.P302S	TCGA-OR-A5JF	ACC	TCGA	PKVTPTKE	DEG_SCF_FBW7_2	0.1944
p.T310S	TCGA-VQ-A8PH	STAD	TCGA	PKVTPTKE	DEG_SCF_FBW7_2	0.8227
p.T310S	DO222349	STAD	ICGC	PKVTPTKE	DEG_SCF_FBW7_2	0.8227
p.E314K	TCGA-W3-A828	SKCM	TCGA	PKVTPTKE	DEG_SCF_FBW7_2	0.7022
p.E314K	DO51273	SKCM	ICGC	PKVTPTKE	DEG_SCF_FBW7_2	0.7022
p.P301T	DO229022	LICA	ICGC	PKVTPTKE	DEG_SCF_FBW7_2	0.1667
p.E318D	DO33037	PACA	ICGC	PKVTPTKE	DEG_SCF_FBW7_2	0.2222
p.P304Q	SIDM00663	Melanoma	GDSC	PKVTPTKE	DEG_SCF_FBW7_2	0.25
p.P304Q	ACH-000814	Skin Cancer	CCLE	PKVTPTKE	DEG_SCF_FBW7_2	0.25
p.P304Q	Hs939-T	skin	COSMIC	PKVTPTKE	DEG_SCF_FBW7_2	0.25
p.T310N	SIDM01176	B-Lymphoblastic Leukemia	GDSC	PKVTPTKE	DEG_SCF_FBW7_2	0.8166
p.T310N	ACH-000059	Leukemia	CCLE	PKVTPTKE	DEG_SCF_FBW7_2	0.8166
p.T310N	SUP-B15	haematopoietic_and_lymphoid_tissue	COSMIC	PKVTPTKE	DEG_SCF_FBW7_2	0.8166
p.P302T	SIDM00208	Glioblastoma	GDSC	PKVTPTKE	DEG_SCF_FBW7_2	0.1944
p.P302T	ACH-002229	Brain Cancer	CCLE	PKVTPTKE	DEG_SCF_FBW7_2	0.1944
p.P302T	D-502MG	central_nervous_system	COSMIC	PKVTPTKE	DEG_SCF_FBW7_2	0.1944
p.R298W	ACH-000490	Cervical Cancer	CCLE	PKVTPTKE	DEG_SCF_FBW7_2	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P49418	Amphiphysin	DEG_SCF_FBW7_2	307:314	PKVTPTKE	FBXW7	0.9961	More...
Q5QJE6	Deoxynucleotidyltransferase terminal-interacting protein 2	DEG_SCF_FBW7_2	126:133	PKVTPTKE	FBXW7	0.9974	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PKVTPTKE

Degron related mutations and impact score

Drug responses associated with AMPH mutations

All proteins holding degron of PKVTPTKE