DegronMD

Uniprot ID: Q5QJE6

Source protein: Deoxynucleotidyltransferase terminal-interacting protein 2

Source gene: DNTTIP2

Class: LIG_APCC_ABBA_1

Location: 619:624

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9999

ASA_SCORE: 78.4167

COIL: 0.8342

CONS_SCORE: 0.5301

DSS_SCORE: 0.481

HELIX: 0.1327

FCONS_SCORE: 1.0318

RIG_SCORE: 0.7413

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P620S	TCGA-DV-A4W0	KIRC	TCGA	VPPYSE	LIG_APCC_ABBA_1	0.5641
p.P620S	DO219235	KIRC	ICGC	VPPYSE	LIG_APCC_ABBA_1	0.5641
p.R633H	DO50393	ESAD	ICGC	VPPYSE	LIG_APCC_ABBA_1	0.0833
p.R633H	SIDM00777	Colorectal Carcinoma	GDSC	VPPYSE	LIG_APCC_ABBA_1	0.0833
p.R633H	SIDM01007	T-Lymphoblastic Leukemia	GDSC	VPPYSE	LIG_APCC_ABBA_1	0.0833
p.R633H	SIDM00400	B-Cell Non-Hodgkin's Lymphoma	GDSC	VPPYSE	LIG_APCC_ABBA_1	0.0833
p.S623G	DO233885	GACA	ICGC	VPPYSE	LIG_APCC_ABBA_1	0.6993
p.P621Q	DO229036	LICA	ICGC	VPPYSE	LIG_APCC_ABBA_1	0.7035
p.Y627C	SIDM00334	Endometrial Carcinoma	GDSC	VPPYSE	LIG_APCC_ABBA_1	0.25
p.Y627C	ACH-000879	Endometrial/Uterine Cancer	CCLE	VPPYSE	LIG_APCC_ABBA_1	0.25
p.K615N	SIDM01081	Oral Cavity Carcinoma	GDSC	VPPYSE	LIG_APCC_ABBA_1	0.3333
p.K615N	ACH-000238	Head and Neck Cancer	CCLE	VPPYSE	LIG_APCC_ABBA_1	0.3333
p.K615N	SCC-4	upper_aerodigestive_tract	COSMIC	VPPYSE	LIG_APCC_ABBA_1	0.3333

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5QJE6	Deoxynucleotidyltransferase terminal-interacting protein 2	LIG_APCC_ABBA_1	619:624	VPPYSE	APC,CDC20,FZR1	0.9999	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons