DegronMD

Uniprot ID: Q5QJE6

Source protein: Deoxynucleotidyltransferase terminal-interacting protein 2

Source gene: DNTTIP2

Class: CBL_PTK

Location: 423:431

E3 ligase: CBL

DEGRON score: 0.9268

ASA_SCORE: 90.0111

COIL: 0.7444

CONS_SCORE: 0.3581

DSS_SCORE: 0.501

HELIX: 0.0443

FCONS_SCORE: 1.0038

RIG_SCORE: 0.7758

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E421Q	TCGA-AC-A23H	BRCA	TCGA	DTKLYTSAP	CBL_PTK	0.2778
p.E421Q	DO2401	BRCA	ICGC	DTKLYTSAP	CBL_PTK	0.2778
p.T433K	DO229032	LICA	ICGC	DTKLYTSAP	CBL_PTK	0.7222
p.G416E	DO50970	LICA	ICGC	DTKLYTSAP	CBL_PTK	0.1389
p.A430V	SIDM00672	Hepatocellular Carcinoma	GDSC	DTKLYTSAP	CBL_PTK	0.5825
p.A430V	SIDM00926	Non-Small Cell Lung Carcinoma	GDSC	DTKLYTSAP	CBL_PTK	0.5825
p.A430V	SIDM01116	Non-Small Cell Lung Carcinoma	GDSC	DTKLYTSAP	CBL_PTK	0.5825
p.A430V	SIDM00656	Burkitt's Lymphoma	GDSC	DTKLYTSAP	CBL_PTK	0.5825
p.A430V	SIDM00654	Small Cell Lung Carcinoma	GDSC	DTKLYTSAP	CBL_PTK	0.5825
p.A430V	SIDM00690	Head and Neck Carcinoma	GDSC	DTKLYTSAP	CBL_PTK	0.5825
p.A430V	SIDM00879	Breast Carcinoma	GDSC	DTKLYTSAP	CBL_PTK	0.5825
p.A430V	SIDM00114	Non-Small Cell Lung Carcinoma	GDSC	DTKLYTSAP	CBL_PTK	0.5825
p.A430V	SIDM00849	Kidney Carcinoma	GDSC	DTKLYTSAP	CBL_PTK	0.5825
p.A430V	SIDM00875	Breast Carcinoma	GDSC	DTKLYTSAP	CBL_PTK	0.5825
p.A430V	SIDM01133	Other Solid Cancers	GDSC	DTKLYTSAP	CBL_PTK	0.5825
p.A430V	SIDM00808	Burkitt's Lymphoma	GDSC	DTKLYTSAP	CBL_PTK	0.5825
p.A430V	SIDM01173	Rhabdomyosarcoma	GDSC	DTKLYTSAP	CBL_PTK	0.5825
p.A430V	SIDM00641	Burkitt's Lymphoma	GDSC	DTKLYTSAP	CBL_PTK	0.5825
p.A430V	SIDM01605	Non-Small Cell Lung Carcinoma	GDSC	DTKLYTSAP	CBL_PTK	0.5825
p.A430V	SIDM01710	Squamous Cell Lung Carcinoma	GDSC	DTKLYTSAP	CBL_PTK	0.5825
p.A430V	SIDM01254	Burkitt's Lymphoma	GDSC	DTKLYTSAP	CBL_PTK	0.5825
p.A430V	SIDM01525	Acute Myeloid Leukemia	GDSC	DTKLYTSAP	CBL_PTK	0.5825
p.D423H	SIDM00230	Small Cell Lung Carcinoma	GDSC	DTKLYTSAP	CBL_PTK	0.7688
p.D423H	SIDM01042	Breast Carcinoma	GDSC	DTKLYTSAP	CBL_PTK	0.7688
p.D423H	ACH-001065	Breast Cancer	CCLE	DTKLYTSAP	CBL_PTK	0.7688
p.D423H	ACH-002145	Lung Cancer	CCLE	DTKLYTSAP	CBL_PTK	0.7688
p.D423H	IST-SL2	lung	COSMIC	DTKLYTSAP	CBL_PTK	0.7688
p.D423H	EVSA-T	breast	COSMIC	DTKLYTSAP	CBL_PTK	0.7688
p.T428M	SIDM00282	Colorectal Carcinoma	GDSC	DTKLYTSAP	CBL_PTK	0.8534
p.T428M	ACH-000998	Colon/Colorectal Cancer	CCLE	DTKLYTSAP	CBL_PTK	0.8534
p.T428M	CW-2	large_intestine	COSMIC	DTKLYTSAP	CBL_PTK	0.8534
p.S429Y	SIDM00214	Colorectal Carcinoma	GDSC	DTKLYTSAP	CBL_PTK	0.712
p.S429Y	ACH-000955	Colon/Colorectal Cancer	CCLE	DTKLYTSAP	CBL_PTK	0.712
p.S429Y	SNU-407	large_intestine	COSMIC	DTKLYTSAP	CBL_PTK	0.712

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: DTKLYTSAP

Degron related mutations and impact score

Drug responses associated with DNTTIP2 mutations

All proteins holding degron of DTKLYTSAP

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5QJE6	Deoxynucleotidyltransferase terminal-interacting protein 2	CBL_PTK	423:431	DTKLYTSAP	CBL	0.9268	More...