DegronMD

Uniprot ID: Q5QJE6

Source protein: Deoxynucleotidyltransferase terminal-interacting protein 2

Source gene: DNTTIP2

Class: DEG_SCF_FBW7_1

Location: 229:236

E3 ligase: FBXW7

DEGRON score: 0.9966

ASA_SCORE: 78.6

COIL: 0.7533

CONS_SCORE: 0.3671

DSS_SCORE: 0.6685

HELIX: 0.0339

FCONS_SCORE: 1.0219

RIG_SCORE: 0.6658

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.I221S	TCGA-BQ-5876	KIRP	TCGA	IVGTPVNS	DEG_SCF_FBW7_1	0.1111
p.I221S	DO20759	KIRP	ICGC	IVGTPVNS	DEG_SCF_FBW7_1	0.1111
p.D238G	TCGA-CD-A4MG	STAD	TCGA	IVGTPVNS	DEG_SCF_FBW7_1	0.2778
p.D238G	DO48009	STAD	ICGC	IVGTPVNS	DEG_SCF_FBW7_1	0.2778
p.E226Q	TCGA-JW-A5VL	CESC	TCGA	IVGTPVNS	DEG_SCF_FBW7_1	0.25
p.E226Q	DO49976	CESC	ICGC	IVGTPVNS	DEG_SCF_FBW7_1	0.25
p.Q228H	TCGA-ZF-A9RF	BLCA	TCGA	IVGTPVNS	DEG_SCF_FBW7_1	0.3056
p.Q228H	DO219074	BLCA	ICGC	IVGTPVNS	DEG_SCF_FBW7_1	0.3056
p.D240N	DO48414	BLCA	ICGC	IVGTPVNS	DEG_SCF_FBW7_1	0.2222
p.P223Q	DO229019	LICA	ICGC	IVGTPVNS	DEG_SCF_FBW7_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5QJE6	Deoxynucleotidyltransferase terminal-interacting protein 2	DEG_SCF_FBW7_1	229:236	IVGTPVNS	FBXW7	0.9966	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons