DegronMD - Q5QP82(DCAF10)

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GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R393Q	TCGA-AG-3892	READ	TCGA	PRNSLEVVT	DEG_APCC_DBOX_1	392:400	Mutation altering degron motif	0.7329
p.R393Q	TCGA-EI-6917	READ	TCGA	PRNSLEVVT	DEG_APCC_DBOX_1	392:400	Mutation altering degron motif	0.7329
p.R393Q	TCGA-EO-A22X	UCEC	TCGA	PRNSLEVVT	DEG_APCC_DBOX_1	392:400	Mutation altering degron motif	0.7329
p.R393Q	DO36394	READ	ICGC	PRNSLEVVT	DEG_APCC_DBOX_1	392:400	Mutation altering degron motif	0.7329
p.R393Q	DO36881	READ	ICGC	PRNSLEVVT	DEG_APCC_DBOX_1	392:400	Mutation altering degron motif	0.7329
p.R393Q	DO43907	UCEC	ICGC	PRNSLEVVT	DEG_APCC_DBOX_1	392:400	Mutation altering degron motif	0.7329
p.L404I	TCGA-AX-A05Z	UCEC	TCGA	PRNSLEVVT	DEG_APCC_DBOX_1	392:400	Mutation rewiring degron network	0.2222
p.L404I	DO40884	UCEC	ICGC	PRNSLEVVT	DEG_APCC_DBOX_1	392:400	Mutation rewiring degron network	0.2222
p.V390A	TCGA-BS-A0UJ	UCEC	TCGA	PRNSLEVVT	DEG_APCC_DBOX_1	392:400	Mutation rewiring degron network	0.2778
p.V390A	DO42745	UCEC	ICGC	PRNSLEVVT	DEG_APCC_DBOX_1	392:400	Mutation rewiring degron network	0.2778
p.G410R	TCGA-CM-4743	COAD	TCGA	PRNSLEVVT	DEG_APCC_DBOX_1	392:400	Mutation rewiring degron network	0.0556
p.G410R	DO8103	COAD	ICGC	PRNSLEVVT	DEG_APCC_DBOX_1	392:400	Mutation rewiring degron network	0.0556
p.S407C	TCGA-DX-A6YX	SARC	TCGA	PRNSLEVVT	DEG_APCC_DBOX_1	392:400	Mutation rewiring degron network	0.1389
p.S407C	DO220013	SARC	ICGC	PRNSLEVVT	DEG_APCC_DBOX_1	392:400	Mutation rewiring degron network	0.1389
p.V399I	TCGA-UD-AAC1	MESO	TCGA	PRNSLEVVT	DEG_APCC_DBOX_1	392:400	Mutation altering degron motif	0.5965
p.V399I	SIDM00761	Small Cell Lung Carcinoma	GDSC	PRNSLEVVT	DEG_APCC_DBOX_1	392:400	Mutation altering degron motif	0.5965
p.V399I	ACH-000752	Lung Cancer	CCLE	PRNSLEVVT	DEG_APCC_DBOX_1	392:400	Mutation altering degron motif	0.5965
p.V399I	NCI-H196	lung	COSMIC	PRNSLEVVT	DEG_APCC_DBOX_1	392:400	Mutation altering degron motif	0.5965
p.S407T	DO223014	ESCA	ICGC	PRNSLEVVT	DEG_APCC_DBOX_1	392:400	Mutation rewiring degron network	0.1389
p.V398F	DO229026	LICA	ICGC	PRNSLEVVT	DEG_APCC_DBOX_1	392:400	Mutation altering degron motif	0.5957
p.R383P	SIDM00061	Ovarian Carcinoma	GDSC	PRNSLEVVT	DEG_APCC_DBOX_1	392:400	Mutation rewiring degron network	0.0833
p.R383P	SIDM00178	Melanoma	GDSC	PRNSLEVVT	DEG_APCC_DBOX_1	392:400	Mutation rewiring degron network	0.0833
p.R383P	SIDM01059	Melanoma	GDSC	PRNSLEVVT	DEG_APCC_DBOX_1	392:400	Mutation rewiring degron network	0.0833
p.R383P	SIDM01628	Non-Small Cell Lung Carcinoma	GDSC	PRNSLEVVT	DEG_APCC_DBOX_1	392:400	Mutation rewiring degron network	0.0833
p.R383P	SIDM01699	Chondrosarcoma	GDSC	PRNSLEVVT	DEG_APCC_DBOX_1	392:400	Mutation rewiring degron network	0.0833
p.R383P	IPC-298	skin	COSMIC	PRNSLEVVT	DEG_APCC_DBOX_1	392:400	Mutation rewiring degron network	0.0833
p.R383G	ACH-000248	Breast Cancer	CCLE	PRNSLEVVT	DEG_APCC_DBOX_1	392:400	Mutation rewiring degron network	0.0833
p.R383G	ACH-000395	Lung Cancer	CCLE	PRNSLEVVT	DEG_APCC_DBOX_1	392:400	Mutation rewiring degron network	0.0833
p.R383G	ACH-000789	Lung Cancer	CCLE	PRNSLEVVT	DEG_APCC_DBOX_1	392:400	Mutation rewiring degron network	0.0833
p.R383G	ACH-000853	Lung Cancer	CCLE	PRNSLEVVT	DEG_APCC_DBOX_1	392:400	Mutation rewiring degron network	0.0833

DegronMD: protein-targeted degradation, mutation and drug response to degrons

DCAF10

UniProt ID: Q5QP82

Entrez ID: 79269

Protein name: DDB1- and CUL4-associated factor 10 (WD repeat-containing protein 32)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for DCAF10 in