DegronMD

Uniprot ID: Q5QP82

Source protein: DDB1- and CUL4-associated factor 10

Source gene: DCAF10

Class: DEG_APCC_DBOX_1

Location: 392:400

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8422

ASA_SCORE: 38.2889

COIL: 0.4489

CONS_SCORE: 0.5695

DSS_SCORE: 0.5805

HELIX: 0.0862

FCONS_SCORE: 1.3763

RIG_SCORE: 0.6813

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R393Q	TCGA-AG-3892	READ	TCGA	PRNSLEVVT	DEG_APCC_DBOX_1	0.7329
p.R393Q	TCGA-EI-6917	READ	TCGA	PRNSLEVVT	DEG_APCC_DBOX_1	0.7329
p.R393Q	TCGA-EO-A22X	UCEC	TCGA	PRNSLEVVT	DEG_APCC_DBOX_1	0.7329
p.R393Q	DO36394	READ	ICGC	PRNSLEVVT	DEG_APCC_DBOX_1	0.7329
p.R393Q	DO36881	READ	ICGC	PRNSLEVVT	DEG_APCC_DBOX_1	0.7329
p.R393Q	DO43907	UCEC	ICGC	PRNSLEVVT	DEG_APCC_DBOX_1	0.7329
p.L404I	TCGA-AX-A05Z	UCEC	TCGA	PRNSLEVVT	DEG_APCC_DBOX_1	0.2222
p.L404I	DO40884	UCEC	ICGC	PRNSLEVVT	DEG_APCC_DBOX_1	0.2222
p.V390A	TCGA-BS-A0UJ	UCEC	TCGA	PRNSLEVVT	DEG_APCC_DBOX_1	0.2778
p.V390A	DO42745	UCEC	ICGC	PRNSLEVVT	DEG_APCC_DBOX_1	0.2778
p.G410R	TCGA-CM-4743	COAD	TCGA	PRNSLEVVT	DEG_APCC_DBOX_1	0.0556
p.G410R	DO8103	COAD	ICGC	PRNSLEVVT	DEG_APCC_DBOX_1	0.0556
p.S407C	TCGA-DX-A6YX	SARC	TCGA	PRNSLEVVT	DEG_APCC_DBOX_1	0.1389
p.S407C	DO220013	SARC	ICGC	PRNSLEVVT	DEG_APCC_DBOX_1	0.1389
p.V399I	TCGA-UD-AAC1	MESO	TCGA	PRNSLEVVT	DEG_APCC_DBOX_1	0.5965
p.V399I	SIDM00761	Small Cell Lung Carcinoma	GDSC	PRNSLEVVT	DEG_APCC_DBOX_1	0.5965
p.V399I	ACH-000752	Lung Cancer	CCLE	PRNSLEVVT	DEG_APCC_DBOX_1	0.5965
p.V399I	NCI-H196	lung	COSMIC	PRNSLEVVT	DEG_APCC_DBOX_1	0.5965
p.S407T	DO223014	ESCA	ICGC	PRNSLEVVT	DEG_APCC_DBOX_1	0.1389
p.V398F	DO229026	LICA	ICGC	PRNSLEVVT	DEG_APCC_DBOX_1	0.5957
p.R383P	SIDM00061	Ovarian Carcinoma	GDSC	PRNSLEVVT	DEG_APCC_DBOX_1	0.0833
p.R383P	SIDM00178	Melanoma	GDSC	PRNSLEVVT	DEG_APCC_DBOX_1	0.0833
p.R383P	SIDM01059	Melanoma	GDSC	PRNSLEVVT	DEG_APCC_DBOX_1	0.0833
p.R383P	SIDM01628	Non-Small Cell Lung Carcinoma	GDSC	PRNSLEVVT	DEG_APCC_DBOX_1	0.0833
p.R383P	SIDM01699	Chondrosarcoma	GDSC	PRNSLEVVT	DEG_APCC_DBOX_1	0.0833
p.R383P	IPC-298	skin	COSMIC	PRNSLEVVT	DEG_APCC_DBOX_1	0.0833
p.R383G	ACH-000248	Breast Cancer	CCLE	PRNSLEVVT	DEG_APCC_DBOX_1	0.0833
p.R383G	ACH-000395	Lung Cancer	CCLE	PRNSLEVVT	DEG_APCC_DBOX_1	0.0833
p.R383G	ACH-000789	Lung Cancer	CCLE	PRNSLEVVT	DEG_APCC_DBOX_1	0.0833
p.R383G	ACH-000853	Lung Cancer	CCLE	PRNSLEVVT	DEG_APCC_DBOX_1	0.0833

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PRNSLEVVT

Degron related mutations and impact score

Drug responses associated with DCAF10 mutations

All proteins holding degron of PRNSLEVVT

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5QP82	DDB1- and CUL4-associated factor 10	DEG_APCC_DBOX_1	392:400	PRNSLEVVT	APC,CDC20,FZR1	0.8422	More...