DegronMD

Uniprot ID: O94986

Source protein: Centrosomal protein of 152 kDa

Source gene: CEP152

Class: DEG_SCF_FBW7_1

Location: 1508:1515

E3 ligase: FBXW7

DEGRON score: 0.6105

ASA_SCORE: 83.5

COIL: 0.8439

CONS_SCORE: 0.3038

DSS_SCORE: 0.493

HELIX: 0.0316

FCONS_SCORE: 0.9624

RIG_SCORE: 0.607

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P1514H	TCGA-AP-A051	UCEC	TCGA	PRCTPGPS	DEG_SCF_FBW7_1	0.6583
p.P1514H	DO42673	UCEC	ICGC	PRCTPGPS	DEG_SCF_FBW7_1	0.6583
p.P1514L	TCGA-FW-A3R5	SKCM	TCGA	PRCTPGPS	DEG_SCF_FBW7_1	0.6471
p.P1514L	DO37406	SKCM	ICGC	PRCTPGPS	DEG_SCF_FBW7_1	0.6471
p.S1517L	TCGA-VQ-AA6F	STAD	TCGA	PRCTPGPS	DEG_SCF_FBW7_1	0.2778
p.S1517L	DO222393	STAD	ICGC	PRCTPGPS	DEG_SCF_FBW7_1	0.2778
p.L1502S	DO230315	COCA	ICGC	PRCTPGPS	DEG_SCF_FBW7_1	0.1667
p.T1501I	DO234011	THCA	ICGC	PRCTPGPS	DEG_SCF_FBW7_1	0.1389
p.R1509G	SIDM00001	Other Blood Cancers	GDSC	PRCTPGPS	DEG_SCF_FBW7_1	0.6457
p.R1509G	ACH-000405	Leukemia	CCLE	PRCTPGPS	DEG_SCF_FBW7_1	0.6457
p.R1525H	SIDM00801	Melanoma	GDSC	PRCTPGPS	DEG_SCF_FBW7_1	0.0556
p.R1525H	ACH-000008	Skin Cancer	CCLE	PRCTPGPS	DEG_SCF_FBW7_1	0.0556
p.R1525H	ACH-000014	Metastasis	CCLE	PRCTPGPS	DEG_SCF_FBW7_1	0.0556
p.R1525H	A101D	skin	COSMIC	PRCTPGPS	DEG_SCF_FBW7_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O94986	Centrosomal protein of 152 kDa	DEG_SCF_FBW7_1	1508:1515	PRCTPGPS	FBXW7	0.6105	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons