DegronMD

Uniprot ID: O94986

Source protein: Centrosomal protein of 152 kDa

Source gene: CEP152

Class: DEG_SCF_TRCP1_1

Location: 1699:1704

E3 ligase: BTRC

DEGRON score: 0.981

ASA_SCORE: 51.6333

COIL: 0.8197

CONS_SCORE: 0

DSS_SCORE: 0.4986

HELIX: 0.071

FCONS_SCORE: 0

RIG_SCORE: 0.6705

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D1703V	TCGA-3B-A9HT	SARC	TCGA	DSGFDS	DEG_SCF_TRCP1_1	0.6674
p.D1703V	DO219934	SARC	ICGC	DSGFDS	DEG_SCF_TRCP1_1	0.6674
p.Q1698P	TCGA-B8-A54H	KIRC	TCGA	DSGFDS	DEG_SCF_TRCP1_1	0.3056
p.Q1698P	DO49733	KIRC	ICGC	DSGFDS	DEG_SCF_TRCP1_1	0.3056
p.D1703H	TCGA-DS-A1OB	CESC	TCGA	DSGFDS	DEG_SCF_TRCP1_1	0.6577
p.D1703H	DO6323	CESC	ICGC	DSGFDS	DEG_SCF_TRCP1_1	0.6577
p.P1693Q	TCGA-EE-A2MS	SKCM	TCGA	DSGFDS	DEG_SCF_TRCP1_1	0.1667
p.P1693Q	DO37567	SKCM	ICGC	DSGFDS	DEG_SCF_TRCP1_1	0.1667
p.S1700G	DO222576	COCA	ICGC	DSGFDS	DEG_SCF_TRCP1_1	0.6993
p.G1701C	DO32391	OV	ICGC	DSGFDS	DEG_SCF_TRCP1_1	0.76

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O94986	Centrosomal protein of 152 kDa	DEG_SCF_TRCP1_1	1699:1704	DSGFDS	BTRC	0.981	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons