DegronMD

Uniprot ID: Q9Y2L6

Source protein: FERM domain-containing protein 4B

Source gene: FRMD4B

Class: DEG_SCF_FBW7_1

Location: 663:670

E3 ligase: FBXW7

DEGRON score: 0.9252

ASA_SCORE: 86.2

COIL: 0.8943

CONS_SCORE: 0.3804

DSS_SCORE: 0.7158

HELIX: 0.0184

FCONS_SCORE: 1.0203

RIG_SCORE: 0.6787

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R656W	TCGA-AJ-A3BH	UCEC	TCGA	MPTTPVLT	DEG_SCF_FBW7_1	0.1389
p.R656W	DO41638	UCEC	ICGC	MPTTPVLT	DEG_SCF_FBW7_1	0.1389
p.L669V	TCGA-BR-A4CQ	STAD	TCGA	MPTTPVLT	DEG_SCF_FBW7_1	0.5654
p.L669V	DO47861	STAD	ICGC	MPTTPVLT	DEG_SCF_FBW7_1	0.5654
p.R656Q	TCGA-CD-A4MG	STAD	TCGA	MPTTPVLT	DEG_SCF_FBW7_1	0.1389
p.R656Q	TCGA-WS-AB45	COAD	TCGA	MPTTPVLT	DEG_SCF_FBW7_1	0.1389
p.R656Q	DO51734	COAD	ICGC	MPTTPVLT	DEG_SCF_FBW7_1	0.1389
p.R656Q	DO48009	STAD	ICGC	MPTTPVLT	DEG_SCF_FBW7_1	0.1389
p.G659E	TCGA-W3-A828	SKCM	TCGA	MPTTPVLT	DEG_SCF_FBW7_1	0.2222
p.G659E	DO51273	SKCM	ICGC	MPTTPVLT	DEG_SCF_FBW7_1	0.2222
p.P664T	DO229032	LICA	ICGC	MPTTPVLT	DEG_SCF_FBW7_1	0.5919
p.P667T	DO229036	LICA	ICGC	MPTTPVLT	DEG_SCF_FBW7_1	0.7031
p.Q658K	DO229038	LICA	ICGC	MPTTPVLT	DEG_SCF_FBW7_1	0.1944
p.D679Y	SK-N-DZ	autonomic_ganglia	COSMIC	MPTTPVLT	DEG_SCF_FBW7_1	0.0833
p.E668K	SR	haematopoietic_and_lymphoid_tissue	COSMIC	MPTTPVLT	DEG_SCF_FBW7_1	0.7022

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9Y2L6	FERM domain-containing protein 4B	DEG_SCF_FBW7_1	663:670	MPTTPVLT	FBXW7	0.9252	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons