DegronMD - P49815(TSC2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S1798C	TCGA-68-8251	LUSC	TCGA	PTPGYE	DEG_SCF_FBW7_2	1784:1789	Mutation blocking phosphorylation signal	0.5278
p.P1098L	TCGA-D3-A8GP	SKCM	TCGA	PESSS	DEG_SPOP_SBC_1	1092:1096	Mutation rewiring degron network	0.2778
p.S1798F	TCGA-EE-A29L	SKCM	TCGA	PTPGYE	DEG_SCF_FBW7_2	1784:1789	Mutation blocking phosphorylation signal	0.5278
p.G1091S	TCGA-FI-A2D0	UCEC	TCGA	PESSS	DEG_SPOP_SBC_1	1092:1096	Mutation rewiring degron network	0.3056
p.D1100Y	DO228952	LICA	ICGC	PESSS	DEG_SPOP_SBC_1	1092:1096	Mutation rewiring degron network	0.2222
p.M1088I	DO229029	LICA	ICGC	PESSS	DEG_SPOP_SBC_1	1092:1096	Mutation rewiring degron network	0.2222
p.G1093C	DO229022	LICA	ICGC	PESSS	DEG_SPOP_SBC_1	1092:1096	Mutation altering degron motif	0.76
p.L1094F	DO38099	SKCM	ICGC	PESSS	DEG_SPOP_SBC_1	1092:1096	Mutation altering degron motif	0.6981
p.V1085I	DO229264	THCA	ICGC	PESSS	DEG_SPOP_SBC_1	1092:1096	Mutation rewiring degron network	0.1389
p.R1084Q	DO41871	UCEC	ICGC	PESSS	DEG_SPOP_SBC_1	1092:1096	Mutation rewiring degron network	0.1111
p.G1787S	SIDM00625	Other Sarcomas	GDSC	PTPGYE	DEG_SCF_FBW7_2	1784:1789	Mutation altering degron motif	0.5882
p.G1787S	SIDM00522	Small Cell Lung Carcinoma	GDSC	PTPGYE	DEG_SCF_FBW7_2	1784:1789	Mutation altering degron motif	0.5882
p.G1787S	SIDM01088	Endometrial Carcinoma	GDSC	PTPGYE	DEG_SCF_FBW7_2	1784:1789	Mutation altering degron motif	0.5882
p.R1795C	SIDM00211	B-Lymphoblastic Leukemia	GDSC	PTPGYE	DEG_SCF_FBW7_2	1784:1789	Mutation rewiring degron network	0.1667
p.R1795C	SIDM00832	Colorectal Carcinoma	GDSC	PTPGYE	DEG_SCF_FBW7_2	1784:1789	Mutation rewiring degron network	0.1667
p.S1774T	SIDM01112	Osteosarcoma	GDSC	PTPGYE	DEG_SCF_FBW7_2	1784:1789	Mutation rewiring degron network	0.0556
p.S1774T	SIDM00138	Non-Small Cell Lung Carcinoma	GDSC	PTPGYE	DEG_SCF_FBW7_2	1784:1789	Mutation rewiring degron network	0.0556
p.A1776G	SIDM00182	Head and Neck Carcinoma	GDSC	PTPGYE	DEG_SCF_FBW7_2	1784:1789	Mutation rewiring degron network	0.1111
p.A1776G	ACH-002265	Head and Neck Cancer	CCLE	PTPGYE	DEG_SCF_FBW7_2	1784:1789	Mutation rewiring degron network	0.1111
p.A1776G	LB771-HNC	upper aerodigestive tract	COSMIC	PTPGYE	DEG_SCF_FBW7_2	1784:1789	Mutation rewiring degron network	0.1111
p.R1793Q	SIDM01609	Endometrial Carcinoma	GDSC	PTPGYE	DEG_SCF_FBW7_2	1784:1789	Mutation rewiring degron network	0.2222
p.S1096F	SIDM01766	Chondrosarcoma	GDSC	PESSS	DEG_SPOP_SBC_1	1092:1096	Mutation altering degron motif	0.9093
p.V1101M	HCC-15	lung	COSMIC	PESSS	DEG_SPOP_SBC_1	1092:1096	Mutation rewiring degron network	0.1944
p.V1101M	U-2-OS	bone	COSMIC	PESSS	DEG_SPOP_SBC_1	1092:1096	Mutation rewiring degron network	0.1944
p.V1100M	U-2-OS	bone	COSMIC	PESSS	DEG_SPOP_SBC_1	1092:1096	Mutation rewiring degron network	0.2222
p.V1100M	HCC-15	lung	COSMIC	PESSS	DEG_SPOP_SBC_1	1092:1096	Mutation rewiring degron network	0.2222
p.A1084P	OVKATE	ovary	COSMIC	PESSS	DEG_SPOP_SBC_1	1092:1096	Mutation rewiring degron network	0.1111
p.A1103V	SK-UT-1	soft tissue	COSMIC	PESSS	DEG_SPOP_SBC_1	1092:1096	Mutation rewiring degron network	0.1389
p.A1774G	LB771-HNC	upper aerodigestive tract	COSMIC	PTPGYE	DEG_SCF_FBW7_2	1784:1789	Mutation rewiring degron network	0.0556
p.R1082Q	KNS-81-FD	central nervous system	COSMIC	PESSS	DEG_SPOP_SBC_1	1092:1096	Mutation rewiring degron network	0.0556
p.A1089T	SBC-5	lung	COSMIC	PESSS	DEG_SPOP_SBC_1	1092:1096	Mutation rewiring degron network	0.25
p.R1094Q	KNS-81-FD	central nervous system	COSMIC	PESSS	DEG_SPOP_SBC_1	1092:1096	Mutation altering degron motif	0.7329

Kaplan plot for TSC2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TSC2

UniProt ID: P49815

Entrez ID: 7249

Protein name: Tuberin (Tuberous sclerosis 2 protein)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for TSC2 in