DegronMD

Uniprot ID: P49815

Source protein: Tuberin

Source gene: TSC2

Class: DEG_SPOP_SBC_1

Location: 1092:1096

E3 ligase: SPOP

DEGRON score: 0.9782

ASA_SCORE: 87.28

COIL: 0.9328

CONS_SCORE: 0.2603

DSS_SCORE: 0.7133

HELIX: 0.0358

FCONS_SCORE: 0.9859

RIG_SCORE: 0.5163

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P1098L	TCGA-D3-A8GP	SKCM	TCGA	PESSS	DEG_SPOP_SBC_1	0.2778
p.G1091S	TCGA-FI-A2D0	UCEC	TCGA	PESSS	DEG_SPOP_SBC_1	0.3056
p.D1100Y	DO228952	LICA	ICGC	PESSS	DEG_SPOP_SBC_1	0.2222
p.M1088I	DO229029	LICA	ICGC	PESSS	DEG_SPOP_SBC_1	0.2222
p.G1093C	DO229022	LICA	ICGC	PESSS	DEG_SPOP_SBC_1	0.76
p.L1094F	DO38099	SKCM	ICGC	PESSS	DEG_SPOP_SBC_1	0.6981
p.V1085I	DO229264	THCA	ICGC	PESSS	DEG_SPOP_SBC_1	0.1389
p.R1084Q	DO41871	UCEC	ICGC	PESSS	DEG_SPOP_SBC_1	0.1111
p.S1096F	SIDM01766	Chondrosarcoma	GDSC	PESSS	DEG_SPOP_SBC_1	0.9093
p.V1101M	HCC-15	lung	COSMIC	PESSS	DEG_SPOP_SBC_1	0.1944
p.V1101M	U-2-OS	bone	COSMIC	PESSS	DEG_SPOP_SBC_1	0.1944
p.V1100M	U-2-OS	bone	COSMIC	PESSS	DEG_SPOP_SBC_1	0.2222
p.V1100M	HCC-15	lung	COSMIC	PESSS	DEG_SPOP_SBC_1	0.2222
p.A1084P	OVKATE	ovary	COSMIC	PESSS	DEG_SPOP_SBC_1	0.1111
p.A1103V	SK-UT-1	soft_tissue	COSMIC	PESSS	DEG_SPOP_SBC_1	0.1389
p.R1082Q	KNS-81-FD	central_nervous_system	COSMIC	PESSS	DEG_SPOP_SBC_1	0.0556
p.A1089T	SBC-5	lung	COSMIC	PESSS	DEG_SPOP_SBC_1	0.25
p.R1094Q	KNS-81-FD	central_nervous_system	COSMIC	PESSS	DEG_SPOP_SBC_1	0.7329

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A1L390	Pleckstrin homology domain-containing family G member 3	DEG_SPOP_SBC_1	866:870	PESSS	SPOP	0.9912	More...
P16112	Aggrecan core protein	DEG_SPOP_SBC_1	2097:2101	PESSS	SPOP	0.9834	More...
P20749	B-cell lymphoma 3 protein	DEG_SPOP_SBC_1	383:387	PESSS	SPOP	0.9491	More...
P31270	Homeobox protein Hox-A11	DEG_SPOP_SBC_1	216:220	PESSS	SPOP	0.8558	More...
P31270	Homeobox protein Hox-A11	DEG_SPOP_SBC_1	222:226	PESSS	SPOP	0.9936	More...
P49815	Tuberin	DEG_SPOP_SBC_1	1092:1096	PESSS	SPOP	0.9782	More...
P78426	Homeobox protein Nkx-6.1	DEG_SPOP_SBC_1	363:367	PESSS	SPOP	0.998	More...
Q03164	Histone-lysine N-methyltransferase 2A	DEG_SPOP_SBC_1	2867:2871	PESSS	SPOP	0.9742	More...
Q12918	Killer cell lectin-like receptor subfamily B member 1	DEG_SPOP_SBC_1	18:22	PESSS	SPOP	0.7957	More...
Q13501	Sequestosome-1	DEG_SPOP_SBC_1	273:277	PESSS	SPOP	0.8106	More...
Q14CM0	FERM and PDZ domain-containing protein 4	DEG_SPOP_SBC_1	901:905	PESSS	SPOP	0.9985	More...
Q5JY77	G-protein coupled receptor-associated sorting protein 1	DEG_SPOP_SBC_1	1137:1141	PESSS	SPOP	0.6247	More...
Q5TCQ9	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 3	DEG_SPOP_SBC_1	1446:1450	PESSS	SPOP	0.9938	More...
Q6UB98	Ankyrin repeat domain-containing protein 12	DEG_SPOP_SBC_1	592:596	PESSS	SPOP	0.9159	More...
Q6V0I7	Protocadherin Fat 4	DEG_SPOP_SBC_1	4836:4840	PESSS	SPOP	0.8987	More...
Q86XP3	ATP-dependent RNA helicase DDX42	DEG_SPOP_SBC_1	847:851	PESSS	SPOP	0.8412	More...
Q9BSD3	RAD9, HUS1, RAD1-interacting nuclear orphan protein 1	DEG_SPOP_SBC_1	160:164	PESSS	SPOP	0.9875	More...
Q9C0C2	182 kDa tankyrase-1-binding protein	DEG_SPOP_SBC_1	678:682	PESSS	SPOP	0.8779	More...
Q9H8Y8	Golgi reassembly-stacking protein 2	DEG_SPOP_SBC_1	372:376	PESSS	SPOP	0.9842	More...
Q9P275	Ubiquitin carboxyl-terminal hydrolase 36	DEG_SPOP_SBC_1	989:993	PESSS	SPOP	0.7219	More...
Q9Y6Q2	Stonin-1	DEG_SPOP_SBC_1	106:110	PESSS	SPOP	0.9755	More...
A6NI28	Rho GTPase-activating protein 42	DEG_SPOP_SBC_1	684:688	PESSS	SPOP	0.9972	More...
Q6T310	Ras-like protein family member 11A	DEG_SPOP_SBC_1	16:20	PESSS	SPOP	0.5145	More...
Q7L1V2	Vacuolar fusion protein MON1 homolog B	DEG_SPOP_SBC_1	89:93	PESSS	SPOP	0.8405	More...
Q8TD94	Krueppel-like factor 14	DEG_SPOP_SBC_1	141:145	PESSS	SPOP	0.99	More...
Q96JQ2	Calmin	DEG_SPOP_SBC_1	482:486	PESSS	SPOP	0.7996	More...
Q96S82	Ubiquitin-like protein 7	DEG_SPOP_SBC_1	282:286	PESSS	SPOP	0.92	More...
Q9Y2L6	FERM domain-containing protein 4B	DEG_SPOP_SBC_1	681:685	PESSS	SPOP	0.9815	More...
Q64ET8	Protein FRG2	DEG_SPOP_SBC_1	86:90	PESSS	SPOP	0.6784	More...
A6NGH7	Coiled-coil domain-containing protein 160	DEG_SPOP_SBC_1	29:33	PESSS	SPOP	0.9785	More...
A6NGY1	Protein FRG2-like-2	DEG_SPOP_SBC_1	87:91	PESSS	SPOP	0.8535	More...
Q3LI81	Keratin-associated protein 27-1	DEG_SPOP_SBC_1	168:172	PESSS	SPOP	0.6466	More...
Q8ND24	RING finger protein 214	DEG_SPOP_SBC_1	17:21	PESSS	SPOP	0.9867	More...
Q96QU4	Protein FRG2-like-1	DEG_SPOP_SBC_1	86:90	PESSS	SPOP	0.8637	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PESSS

Degron related mutations and impact score

Drug responses associated with TSC2 mutations

All proteins holding degron of PESSS