DegronMD - Q86XP3(DDX42)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R858W	TCGA-13-0884	OV	TCGA	PESSS	DEG_SPOP_SBC_1	847:851	Mutation rewiring degron network	0.1389
p.R852G	TCGA-44-A47B	LUAD	TCGA	PESSS	DEG_SPOP_SBC_1	847:851	Mutation rewiring degron network	0.3056
p.K918R	TCGA-56-7822	LUSC	TCGA	TADGFAVPEP	DEG_COP1_1	919:928	Mutation rewiring degron network	0.3056
p.K918R	DO26638	LUSC	ICGC	TADGFAVPEP	DEG_COP1_1	919:928	Mutation rewiring degron network	0.3056
p.R839H	TCGA-AA-3984	COAD	TCGA	PESSS	DEG_SPOP_SBC_1	847:851	Mutation rewiring degron network	0.1111
p.G593S	TCGA-AN-A0AK	BRCA	TCGA	LLTPKDS	DEG_SCF_FBW7_1	601:607	Mutation rewiring degron network	0.1111
p.R615Q	TCGA-AP-A0LM	UCEC	TCGA	LLTPKDS	DEG_SCF_FBW7_1	601:607	Mutation rewiring degron network	0.1111
p.G860R	TCGA-BG-A0LX	UCEC	TCGA	PESSS	DEG_SPOP_SBC_1	847:851	Mutation rewiring degron network	0.0833
p.A920V	TCGA-BR-4184	STAD	TCGA	TADGFAVPEP	DEG_COP1_1	919:928	Mutation altering degron motif	0.5825
p.R615L	TCGA-DD-A1EE	LIHC	TCGA	LLTPKDS	DEG_SCF_FBW7_1	601:607	Mutation rewiring degron network	0.1111
p.R615L	TCGA-G3-A25Z	LIHC	TCGA	LLTPKDS	DEG_SCF_FBW7_1	601:607	Mutation rewiring degron network	0.1111
p.R858Q	TCGA-DU-6392	LGG	TCGA	PESSS	DEG_SPOP_SBC_1	847:851	Mutation rewiring degron network	0.1389
p.G837C	TCGA-EB-A299	SKCM	TCGA	PESSS	DEG_SPOP_SBC_1	847:851	Mutation rewiring degron network	0.0556
p.R852S	TCGA-EE-A2GT	SKCM	TCGA	PESSS	DEG_SPOP_SBC_1	847:851	Mutation rewiring degron network	0.3056
p.F39S	TCGA-EJ-5524	PRAD	TCGA	ATSSS	DEG_SPOP_SBC_1	41:45	Mutation rewiring degron network	0.2778
p.F39S	DO36284	PRAD	ICGC	ATSSS	DEG_SPOP_SBC_1	41:45	Mutation rewiring degron network	0.2778
p.S849N	TCGA-EK-A2RD	CESC	TCGA	PESSS	DEG_SPOP_SBC_1	847:851	Mutation altering degron motif	0.7069
p.R931H	TCGA-HU-A4GT	STAD	TCGA	TADGFAVPEP	DEG_COP1_1	919:928	Mutation rewiring degron network	0.25
p.R931H	DO48020	STAD	ICGC	TADGFAVPEP	DEG_COP1_1	919:928	Mutation rewiring degron network	0.25
p.G856S	TCGA-VQ-A922	STAD	TCGA	PESSS	DEG_SPOP_SBC_1	847:851	Mutation rewiring degron network	0.1944
p.G856S	SIDM01343	Gastric Carcinoma	GDSC	PESSS	DEG_SPOP_SBC_1	847:851	Mutation rewiring degron network	0.1944
p.G856S	ACH-000764	Gastric Cancer	CCLE	PESSS	DEG_SPOP_SBC_1	847:851	Mutation rewiring degron network	0.1944
p.H591N	DO8730	COAD	ICGC	LLTPKDS	DEG_SCF_FBW7_1	601:607	Mutation rewiring degron network	0.0556
p.V53M	DO233109	GACA	ICGC	ATSSS	DEG_SPOP_SBC_1	41:45	Mutation rewiring degron network	0.1111
p.S37I	DO228974	LICA	ICGC	ATSSS	DEG_SPOP_SBC_1	41:45	Mutation rewiring degron network	0.2222
p.A38S	DO229009	LICA	ICGC	ATSSS	DEG_SPOP_SBC_1	41:45	Mutation rewiring degron network	0.25
p.F592C	DO50811	LIRI	ICGC	LLTPKDS	DEG_SCF_FBW7_1	601:607	Mutation rewiring degron network	0.0833
p.A607D	DO23986	LUAD	ICGC	LLTPKDS	DEG_SCF_FBW7_1	601:607	Mutation altering degron motif	0.7793
p.A51V	DO46542	OV	ICGC	ATSSS	DEG_SPOP_SBC_1	41:45	Mutation blocking phosphorylation signal	0.6111
p.A51V	RL95-2	endometrium	COSMIC	ATSSS	DEG_SPOP_SBC_1	41:45	Mutation blocking phosphorylation signal	0.6111
p.L31P	DO35242	PACA	ICGC	ATSSS	DEG_SPOP_SBC_1	41:45	Mutation rewiring degron network	0.0556
p.G611W	DO37886	SKCM	ICGC	LLTPKDS	DEG_SCF_FBW7_1	601:607	Mutation rewiring degron network	0.2222
p.A606V	DO43049	UCEC	ICGC	LLTPKDS	DEG_SCF_FBW7_1	601:607	Mutation altering degron motif	0.6936
p.D31N	DO41331	UCEC	ICGC	ATSSS	DEG_SPOP_SBC_1	41:45	Mutation rewiring degron network	0.0556
p.T42A	SIDM00845	Burkitt's Lymphoma	GDSC	ATSSS	DEG_SPOP_SBC_1	41:45	Mutation altering degron motif	0.6028
p.T42A	SIDM00461	Acute Myeloid Leukemia	GDSC	ATSSS	DEG_SPOP_SBC_1	41:45	Mutation altering degron motif	0.6028
p.T42A	ACH-000786	Lymphoma	CCLE	ATSSS	DEG_SPOP_SBC_1	41:45	Mutation altering degron motif	0.6028
p.A920T	SIDM00333	Endometrial Carcinoma	GDSC	TADGFAVPEP	DEG_COP1_1	919:928	Mutation altering degron motif	0.6028
p.A920T	ACH-000988	Endometrial/Uterine Cancer	CCLE	TADGFAVPEP	DEG_COP1_1	919:928	Mutation altering degron motif	0.6028
p.A920T	MFE-319	endometrium	COSMIC	TADGFAVPEP	DEG_COP1_1	919:928	Mutation altering degron motif	0.6028
p.T919I	SIDM00527	Colorectal Carcinoma	GDSC	TADGFAVPEP	DEG_COP1_1	919:928	Mutation altering degron motif	0.7078
p.T919I	ACH-000935	Colon/Colorectal Cancer	CCLE	TADGFAVPEP	DEG_COP1_1	919:928	Mutation altering degron motif	0.7078
p.T919I	MDST8	large intestine	COSMIC	TADGFAVPEP	DEG_COP1_1	919:928	Mutation altering degron motif	0.7078
p.S44C	NCI-H1568	lung	COSMIC	ATSSS	DEG_SPOP_SBC_1	41:45	Mutation altering degron motif	0.7541

Kaplan plot for DDX42 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

DDX42

UniProt ID: Q86XP3

Entrez ID: 11325

Protein name: ATP-dependent RNA helicase DDX42 (EC 3.6.4.13) (DEAD box protein 42) (RNA helicase-like protein) (RHELP) (RNA helicase-related protein) (RNAHP) (SF3b DEAD box protein) (Splicing factor 3B-associated 125 kDa protein) (SF3b125)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for DDX42 in