DegronMD

Uniprot ID: Q86XP3

Source protein: ATP-dependent RNA helicase DDX42

Source gene: DDX42

Class: DEG_COP1_1

Location: 919:928

E3 ligase: COP1

DEGRON score: 0.9699

ASA_SCORE: 70.17

COIL: 0.8641

CONS_SCORE: 0.2652

DSS_SCORE: 0.6594

HELIX: 0.0309

FCONS_SCORE: 0.9202

RIG_SCORE: 0.6825

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K918R	TCGA-56-7822	LUSC	TCGA	TADGFAVPEP	DEG_COP1_1	0.3056
p.K918R	DO26638	LUSC	ICGC	TADGFAVPEP	DEG_COP1_1	0.3056
p.A920V	TCGA-BR-4184	STAD	TCGA	TADGFAVPEP	DEG_COP1_1	0.5825
p.R931H	TCGA-HU-A4GT	STAD	TCGA	TADGFAVPEP	DEG_COP1_1	0.25
p.R931H	DO48020	STAD	ICGC	TADGFAVPEP	DEG_COP1_1	0.25
p.A920T	SIDM00333	Endometrial Carcinoma	GDSC	TADGFAVPEP	DEG_COP1_1	0.6028
p.A920T	ACH-000988	Endometrial/Uterine Cancer	CCLE	TADGFAVPEP	DEG_COP1_1	0.6028
p.A920T	MFE-319	endometrium	COSMIC	TADGFAVPEP	DEG_COP1_1	0.6028
p.T919I	SIDM00527	Colorectal Carcinoma	GDSC	TADGFAVPEP	DEG_COP1_1	0.7078
p.T919I	ACH-000935	Colon/Colorectal Cancer	CCLE	TADGFAVPEP	DEG_COP1_1	0.7078
p.T919I	MDST8	large_intestine	COSMIC	TADGFAVPEP	DEG_COP1_1	0.7078

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q86XP3	ATP-dependent RNA helicase DDX42	DEG_COP1_1	919:928	TADGFAVPEP	COP1	0.9699	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons