DegronMD

Uniprot ID: Q86XP3

Source protein: ATP-dependent RNA helicase DDX42

Source gene: DDX42

Class: DEG_SPOP_SBC_1

Location: 847:851

E3 ligase: SPOP

DEGRON score: 0.8412

ASA_SCORE: 85.5

COIL: 0.8684

CONS_SCORE: 0.2527

DSS_SCORE: 0.8297

HELIX: 0.124

FCONS_SCORE: 1.0181

RIG_SCORE: 0.495

Degron related mutations and impact score

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S849N	TCGA-EK-A2RD	CESC	TCGA	PESSS	DEG_SPOP_SBC_1	0.7069
p.R852G	TCGA-44-A47B	LUAD	TCGA	PESSS	DEG_SPOP_SBC_1	0.3056
p.R852S	TCGA-EE-A2GT	SKCM	TCGA	PESSS	DEG_SPOP_SBC_1	0.3056
p.G856S	TCGA-VQ-A922	STAD	TCGA	PESSS	DEG_SPOP_SBC_1	0.1944
p.G856S	SIDM01343	Gastric Carcinoma	GDSC	PESSS	DEG_SPOP_SBC_1	0.1944
p.G856S	ACH-000764	Gastric Cancer	CCLE	PESSS	DEG_SPOP_SBC_1	0.1944
p.R858W	TCGA-13-0884	OV	TCGA	PESSS	DEG_SPOP_SBC_1	0.1389
p.R858Q	TCGA-DU-6392	LGG	TCGA	PESSS	DEG_SPOP_SBC_1	0.1389
p.R839H	TCGA-AA-3984	COAD	TCGA	PESSS	DEG_SPOP_SBC_1	0.1111
p.G860R	TCGA-BG-A0LX	UCEC	TCGA	PESSS	DEG_SPOP_SBC_1	0.0833
p.G837C	TCGA-EB-A299	SKCM	TCGA	PESSS	DEG_SPOP_SBC_1	0.0556

Showing 1 to 11 of 11 entries

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Drug responses associated with DDX42 mutations

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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All proteins holding degron of PESSS

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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9C0C2	182 kDa tankyrase-1-binding protein	DEG_SPOP_SBC_1	678:682	PESSS	SPOP	0.8779	More...
P16112	Aggrecan core protein	DEG_SPOP_SBC_1	2097:2101	PESSS	SPOP	0.9834	More...
Q6UB98	Ankyrin repeat domain-containing protein 12	DEG_SPOP_SBC_1	592:596	PESSS	SPOP	0.9159	More...
Q86XP3	ATP-dependent RNA helicase DDX42	DEG_SPOP_SBC_1	847:851	PESSS	SPOP	0.8412	More...
P20749	B-cell lymphoma 3 protein	DEG_SPOP_SBC_1	383:387	PESSS	SPOP	0.9491	More...
Q96JQ2	Calmin	DEG_SPOP_SBC_1	482:486	PESSS	SPOP	0.7996	More...
A6NGH7	Coiled-coil domain-containing protein 160	DEG_SPOP_SBC_1	29:33	PESSS	SPOP	0.9785	More...
Q14CM0	FERM and PDZ domain-containing protein 4	DEG_SPOP_SBC_1	901:905	PESSS	SPOP	0.9985	More...
Q9Y2L6	FERM domain-containing protein 4B	DEG_SPOP_SBC_1	681:685	PESSS	SPOP	0.9815	More...
Q5JY77	G-protein coupled receptor-associated sorting protein 1	DEG_SPOP_SBC_1	1137:1141	PESSS	SPOP	0.6247	More...
Q9H8Y8	Golgi reassembly-stacking protein 2	DEG_SPOP_SBC_1	372:376	PESSS	SPOP	0.9842	More...
Q03164	Histone-lysine N-methyltransferase 2A	DEG_SPOP_SBC_1	2867:2871	PESSS	SPOP	0.9742	More...
P31270	Homeobox protein Hox-A11	DEG_SPOP_SBC_1	216:220	PESSS	SPOP	0.8558	More...
P31270	Homeobox protein Hox-A11	DEG_SPOP_SBC_1	222:226	PESSS	SPOP	0.9936	More...
P78426	Homeobox protein Nkx-6.1	DEG_SPOP_SBC_1	363:367	PESSS	SPOP	0.998	More...
Q3LI81	Keratin-associated protein 27-1	DEG_SPOP_SBC_1	168:172	PESSS	SPOP	0.6466	More...
Q12918	Killer cell lectin-like receptor subfamily B member 1	DEG_SPOP_SBC_1	18:22	PESSS	SPOP	0.7957	More...
Q8TD94	Krueppel-like factor 14	DEG_SPOP_SBC_1	141:145	PESSS	SPOP	0.99	More...
Q5TCQ9	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 3	DEG_SPOP_SBC_1	1446:1450	PESSS	SPOP	0.9938	More...
A1L390	Pleckstrin homology domain-containing family G member 3	DEG_SPOP_SBC_1	866:870	PESSS	SPOP	0.9912	More...
Q64ET8	Protein FRG2	DEG_SPOP_SBC_1	86:90	PESSS	SPOP	0.6784	More...
Q96QU4	Protein FRG2-like-1	DEG_SPOP_SBC_1	86:90	PESSS	SPOP	0.8637	More...
A6NGY1	Protein FRG2-like-2	DEG_SPOP_SBC_1	87:91	PESSS	SPOP	0.8535	More...
Q6V0I7	Protocadherin Fat 4	DEG_SPOP_SBC_1	4836:4840	PESSS	SPOP	0.8987	More...
Q9BSD3	RAD9, HUS1, RAD1-interacting nuclear orphan protein 1	DEG_SPOP_SBC_1	160:164	PESSS	SPOP	0.9875	More...

Showing 1 to 25 of 34 entries

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PESSS

Degron related mutations and impact score

Drug responses associated with DDX42 mutations

All proteins holding degron of PESSS