DegronMD - A6NI28(ARHGAP42)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P617S	TCGA-A1-A0SK	BRCA	TCGA	PDSTPMGS	DEG_SCF_FBW7_1	626:633	Mutation rewiring degron network	0.0833
p.P617S	TCGA-A1-A0SK	BRCA	TCGA	DSDSYSSSP	CBL_PTK	618:626	Mutation rewiring degron network	0.3056
p.P617S	DO4143	BRCA	ICGC	PDSTPMGS	DEG_SCF_FBW7_1	626:633	Mutation rewiring degron network	0.0833
p.P617S	DO4143	BRCA	ICGC	DSDSYSSSP	CBL_PTK	618:626	Mutation rewiring degron network	0.3056
p.G660A	TCGA-BH-A18P	BRCA	TCGA	IATPSSS	DEG_SCF_FBW7_1	665:671	Mutation rewiring degron network	0.1944
p.G660A	DO3346	BRCA	ICGC	IATPSSS	DEG_SCF_FBW7_1	665:671	Mutation rewiring degron network	0.1944
p.D618H	TCGA-C8-A8HQ	BRCA	TCGA	DSDSYSSSP	CBL_PTK	618:626	Mutation altering degron motif	0.7688
p.D618H	TCGA-IR-A3LH	CESC	TCGA	DSDSYSSSP	CBL_PTK	618:626	Mutation altering degron motif	0.7688
p.D618H	DO219623	BRCA	ICGC	DSDSYSSSP	CBL_PTK	618:626	Mutation altering degron motif	0.7688
p.D618H	DO44381	CESC	ICGC	DSDSYSSSP	CBL_PTK	618:626	Mutation altering degron motif	0.7688
p.Q674H	TCGA-CA-6718	COAD	TCGA	IATPSSS	DEG_SCF_FBW7_1	665:671	Mutation rewiring degron network	0.25
p.Q674H	TCGA-CA-6718	COAD	TCGA	PESSS	DEG_SPOP_SBC_1	684:688	Mutation rewiring degron network	0.0556
p.Q674H	DO7801	COAD	ICGC	IATPSSS	DEG_SCF_FBW7_1	665:671	Mutation rewiring degron network	0.25
p.Q674H	DO7801	COAD	ICGC	PESSS	DEG_SPOP_SBC_1	684:688	Mutation rewiring degron network	0.0556
p.S671P	TCGA-E6-A1LX	UCEC	TCGA	IATPSSS	DEG_SCF_FBW7_1	665:671	Mutation altering degron motif	0.6752
p.S671P	DO41020	UCEC	ICGC	IATPSSS	DEG_SCF_FBW7_1	665:671	Mutation altering degron motif	0.6752
p.P626L	DO49300	ALL	ICGC	PDSTPMGS	DEG_SCF_FBW7_1	626:633	Mutation altering degron motif	0.6471
p.P626L	DO49300	ALL	ICGC	DSDSYSSSP	CBL_PTK	618:626	Mutation altering degron motif	0.7582
p.S676N	DO217907	BRCA	ICGC	IATPSSS	DEG_SCF_FBW7_1	665:671	Mutation rewiring degron network	0.1944
p.S676N	DO217907	BRCA	ICGC	PESSS	DEG_SPOP_SBC_1	684:688	Mutation rewiring degron network	0.1111
p.A615V	DO233109	GACA	ICGC	DSDSYSSSP	CBL_PTK	618:626	Mutation rewiring degron network	0.25
p.D620G	DO233732	GACA	ICGC	DSDSYSSSP	CBL_PTK	618:626	Mutation altering degron motif	0.6087
p.W664C	DO228985	LICA	ICGC	IATPSSS	DEG_SCF_FBW7_1	665:671	Mutation rewiring degron network	0.3056
p.A692S	DO229029	LICA	ICGC	PESSS	DEG_SPOP_SBC_1	684:688	Mutation rewiring degron network	0.2222
p.T667A	DO231086	LUSC	ICGC	IATPSSS	DEG_SCF_FBW7_1	665:671	Mutation altering degron motif	0.7139
p.K675R	DO228818	MALY	ICGC	IATPSSS	DEG_SCF_FBW7_1	665:671	Mutation substituting flanking lysine	0.3333
p.K675R	DO228818	MALY	ICGC	PESSS	DEG_SPOP_SBC_1	684:688	Mutation substituting flanking lysine	0.1944
p.S641F	DO218863	SKCA	ICGC	PDSTPMGS	DEG_SCF_FBW7_1	626:633	Mutation blocking phosphorylation signal	0.5556
p.A666V	DO229248	THCA	ICGC	IATPSSS	DEG_SCF_FBW7_1	665:671	Mutation altering degron motif	0.5825
p.P626T	SIDM01278	Colorectal Carcinoma	GDSC	PDSTPMGS	DEG_SCF_FBW7_1	626:633	Mutation altering degron motif	0.7031
p.P626T	SIDM01278	Colorectal Carcinoma	GDSC	DSDSYSSSP	CBL_PTK	618:626	Mutation altering degron motif	0.7031
p.L677F	SIDM01962	Colorectal Carcinoma	GDSC	IATPSSS	DEG_SCF_FBW7_1	665:671	Mutation rewiring degron network	0.1667
p.L677F	SIDM01962	Colorectal Carcinoma	GDSC	PESSS	DEG_SPOP_SBC_1	684:688	Mutation rewiring degron network	0.1389
p.L677P	SIDM00661	B-Cell Non-Hodgkin's Lymphoma	GDSC	IATPSSS	DEG_SCF_FBW7_1	665:671	Mutation rewiring degron network	0.1667
p.L677P	SIDM00661	B-Cell Non-Hodgkin's Lymphoma	GDSC	PESSS	DEG_SPOP_SBC_1	684:688	Mutation rewiring degron network	0.1389
p.L677P	ACH-000914	Lymphoma	CCLE	IATPSSS	DEG_SCF_FBW7_1	665:671	Mutation rewiring degron network	0.1667
p.L677P	ACH-000914	Lymphoma	CCLE	PESSS	DEG_SPOP_SBC_1	684:688	Mutation rewiring degron network	0.1389
p.L677P	HT	haematopoietic and lymphoid tissue	COSMIC	IATPSSS	DEG_SCF_FBW7_1	665:671	Mutation rewiring degron network	0.1667
p.L677P	HT	haematopoietic and lymphoid tissue	COSMIC	PESSS	DEG_SPOP_SBC_1	684:688	Mutation rewiring degron network	0.1389
p.R689I	SIDM00018	Acute Myeloid Leukemia	GDSC	PESSS	DEG_SPOP_SBC_1	684:688	Mutation rewiring degron network	0.3056
p.R689I	ACH-000498	Leukemia	CCLE	PESSS	DEG_SPOP_SBC_1	684:688	Mutation rewiring degron network	0.3056
p.R689I	KO52	haematopoietic and lymphoid tissue	COSMIC	PESSS	DEG_SPOP_SBC_1	684:688	Mutation rewiring degron network	0.3056
p.L643P	HT	haematopoietic and lymphoid tissue	COSMIC	PDSTPMGS	DEG_SCF_FBW7_1	626:633	Mutation rewiring degron network	0.0556
p.R655I	KO52	haematopoietic and lymphoid tissue	COSMIC	IATPSSS	DEG_SCF_FBW7_1	665:671	Mutation rewiring degron network	0.0556

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ARHGAP42

UniProt ID: A6NI28

Entrez ID: 143872

Protein name: Rho GTPase-activating protein 42 (Rho GTPase-activating protein 10-like) (Rho-type GTPase-activating protein 42)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ARHGAP42 in