DegronMD

Uniprot ID: A6NI28

Source protein: Rho GTPase-activating protein 42

Source gene: ARHGAP42

Class: DEG_SCF_FBW7_1

Location: 626:633

E3 ligase: FBXW7

DEGRON score: 0.997

ASA_SCORE: 72.975

COIL: 0.8988

CONS_SCORE: 0.3896

DSS_SCORE: 0.6747

HELIX: 0.043

FCONS_SCORE: 1.0625

RIG_SCORE: 0.5558

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P617S	TCGA-A1-A0SK	BRCA	TCGA	PDSTPMGS	DEG_SCF_FBW7_1	0.0833
p.P617S	DO4143	BRCA	ICGC	PDSTPMGS	DEG_SCF_FBW7_1	0.0833
p.P626L	DO49300	ALL	ICGC	PDSTPMGS	DEG_SCF_FBW7_1	0.6471
p.S641F	DO218863	SKCA	ICGC	PDSTPMGS	DEG_SCF_FBW7_1	0.5556
p.P626T	SIDM01278	Colorectal Carcinoma	GDSC	PDSTPMGS	DEG_SCF_FBW7_1	0.7031
p.L643P	HT	haematopoietic_and_lymphoid_tissue	COSMIC	PDSTPMGS	DEG_SCF_FBW7_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A6NI28	Rho GTPase-activating protein 42	DEG_SCF_FBW7_1	626:633	PDSTPMGS	FBXW7	0.997	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons