DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
DSDSYSSSP
Uniprot ID:
A6NI28
Source protein:
Rho GTPase-activating protein 42
Source gene:
ARHGAP42
Class:
CBL_PTK
Location:
618:626
E3 ligase:
CBL
DEGRON score:
0.9967
ASA_SCORE:
80.3889
COIL:
0.9059
CONS_SCORE:
0.4193
DSS_SCORE:
0.6426
HELIX:
0.0669
FCONS_SCORE:
1.1579
RIG_SCORE:
0.5818
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.P617S
TCGA-A1-A0SK
BRCA
TCGA
DSDSYSSSP
CBL_PTK
0.3056
p.P617S
DO4143
BRCA
ICGC
DSDSYSSSP
CBL_PTK
0.3056
p.D618H
TCGA-C8-A8HQ
BRCA
TCGA
DSDSYSSSP
CBL_PTK
0.7688
p.D618H
TCGA-IR-A3LH
CESC
TCGA
DSDSYSSSP
CBL_PTK
0.7688
p.D618H
DO219623
BRCA
ICGC
DSDSYSSSP
CBL_PTK
0.7688
p.D618H
DO44381
CESC
ICGC
DSDSYSSSP
CBL_PTK
0.7688
p.P626L
DO49300
ALL
ICGC
DSDSYSSSP
CBL_PTK
0.7582
p.A615V
DO233109
GACA
ICGC
DSDSYSSSP
CBL_PTK
0.25
p.D620G
DO233732
GACA
ICGC
DSDSYSSSP
CBL_PTK
0.6087
p.P626T
SIDM01278
Colorectal Carcinoma
GDSC
DSDSYSSSP
CBL_PTK
0.7031
Drug responses associated with ARHGAP42 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of DSDSYSSSP
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
A6NI28
Rho GTPase-activating protein 42
CBL_PTK
618:626
DSDSYSSSP
CBL
0.9967
More...
