DegronMD

Uniprot ID: A6NI28

Source protein: Rho GTPase-activating protein 42

Source gene: ARHGAP42

Class: DEG_SCF_FBW7_1

Location: 665:671

E3 ligase: FBXW7

DEGRON score: 0.9936

ASA_SCORE: 76.8143

COIL: 0.9391

CONS_SCORE: 0.3305

DSS_SCORE: 0.6142

HELIX: 0.0317

FCONS_SCORE: 0.9114

RIG_SCORE: 0.6677

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G660A	TCGA-BH-A18P	BRCA	TCGA	IATPSSS	DEG_SCF_FBW7_1	0.1944
p.G660A	DO3346	BRCA	ICGC	IATPSSS	DEG_SCF_FBW7_1	0.1944
p.Q674H	TCGA-CA-6718	COAD	TCGA	IATPSSS	DEG_SCF_FBW7_1	0.25
p.Q674H	DO7801	COAD	ICGC	IATPSSS	DEG_SCF_FBW7_1	0.25
p.S671P	TCGA-E6-A1LX	UCEC	TCGA	IATPSSS	DEG_SCF_FBW7_1	0.6752
p.S671P	DO41020	UCEC	ICGC	IATPSSS	DEG_SCF_FBW7_1	0.6752
p.S676N	DO217907	BRCA	ICGC	IATPSSS	DEG_SCF_FBW7_1	0.1944
p.W664C	DO228985	LICA	ICGC	IATPSSS	DEG_SCF_FBW7_1	0.3056
p.T667A	DO231086	LUSC	ICGC	IATPSSS	DEG_SCF_FBW7_1	0.7139
p.K675R	DO228818	MALY	ICGC	IATPSSS	DEG_SCF_FBW7_1	0.3333
p.A666V	DO229248	THCA	ICGC	IATPSSS	DEG_SCF_FBW7_1	0.5825
p.L677F	SIDM01962	Colorectal Carcinoma	GDSC	IATPSSS	DEG_SCF_FBW7_1	0.1667
p.L677P	SIDM00661	B-Cell Non-Hodgkin's Lymphoma	GDSC	IATPSSS	DEG_SCF_FBW7_1	0.1667
p.L677P	ACH-000914	Lymphoma	CCLE	IATPSSS	DEG_SCF_FBW7_1	0.1667
p.L677P	HT	haematopoietic_and_lymphoid_tissue	COSMIC	IATPSSS	DEG_SCF_FBW7_1	0.1667
p.R655I	KO52	haematopoietic_and_lymphoid_tissue	COSMIC	IATPSSS	DEG_SCF_FBW7_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A6NI28	Rho GTPase-activating protein 42	DEG_SCF_FBW7_1	665:671	IATPSSS	FBXW7	0.9936	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons