DegronMD

Uniprot ID: Q86XP3

Source protein: ATP-dependent RNA helicase DDX42

Source gene: DDX42

Class: DEG_SCF_FBW7_1

Location: 601:607

E3 ligase: FBXW7

DEGRON score: 0.6388

ASA_SCORE: 46.0571

COIL: 0.462

CONS_SCORE: 0.4626

DSS_SCORE: 0.3033

HELIX: 0.3617

FCONS_SCORE: 0.7823

RIG_SCORE: 0.7914

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G593S	TCGA-AN-A0AK	BRCA	TCGA	LLTPKDS	DEG_SCF_FBW7_1	0.1111
p.R615Q	TCGA-AP-A0LM	UCEC	TCGA	LLTPKDS	DEG_SCF_FBW7_1	0.1111
p.R615L	TCGA-DD-A1EE	LIHC	TCGA	LLTPKDS	DEG_SCF_FBW7_1	0.1111
p.R615L	TCGA-G3-A25Z	LIHC	TCGA	LLTPKDS	DEG_SCF_FBW7_1	0.1111
p.H591N	DO8730	COAD	ICGC	LLTPKDS	DEG_SCF_FBW7_1	0.0556
p.F592C	DO50811	LIRI	ICGC	LLTPKDS	DEG_SCF_FBW7_1	0.0833
p.A607D	DO23986	LUAD	ICGC	LLTPKDS	DEG_SCF_FBW7_1	0.7793
p.G611W	DO37886	SKCM	ICGC	LLTPKDS	DEG_SCF_FBW7_1	0.2222
p.A606V	DO43049	UCEC	ICGC	LLTPKDS	DEG_SCF_FBW7_1	0.6936

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q86XP3	ATP-dependent RNA helicase DDX42	DEG_SCF_FBW7_1	601:607	LLTPKDS	FBXW7	0.6388	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons