DegronMD

Uniprot ID: P49815

Source protein: Tuberin

Source gene: TSC2

Class: DEG_SCF_FBW7_2

Location: 1784:1789

E3 ligase: FBXW7

DEGRON score: 0.8419

ASA_SCORE: 83.3167

COIL: 0.9042

CONS_SCORE: 0.2455

DSS_SCORE: 0.6487

HELIX: 0.065

FCONS_SCORE: 0.9386

RIG_SCORE: 0.6535

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S1798C	TCGA-68-8251	LUSC	TCGA	PTPGYE	DEG_SCF_FBW7_2	0.5278
p.S1798F	TCGA-EE-A29L	SKCM	TCGA	PTPGYE	DEG_SCF_FBW7_2	0.5278
p.G1787S	SIDM00625	Other Sarcomas	GDSC	PTPGYE	DEG_SCF_FBW7_2	0.5882
p.G1787S	SIDM00522	Small Cell Lung Carcinoma	GDSC	PTPGYE	DEG_SCF_FBW7_2	0.5882
p.G1787S	SIDM01088	Endometrial Carcinoma	GDSC	PTPGYE	DEG_SCF_FBW7_2	0.5882
p.R1795C	SIDM00211	B-Lymphoblastic Leukemia	GDSC	PTPGYE	DEG_SCF_FBW7_2	0.1667
p.R1795C	SIDM00832	Colorectal Carcinoma	GDSC	PTPGYE	DEG_SCF_FBW7_2	0.1667
p.S1774T	SIDM01112	Osteosarcoma	GDSC	PTPGYE	DEG_SCF_FBW7_2	0.0556
p.S1774T	SIDM00138	Non-Small Cell Lung Carcinoma	GDSC	PTPGYE	DEG_SCF_FBW7_2	0.0556
p.A1776G	SIDM00182	Head and Neck Carcinoma	GDSC	PTPGYE	DEG_SCF_FBW7_2	0.1111
p.A1776G	ACH-002265	Head and Neck Cancer	CCLE	PTPGYE	DEG_SCF_FBW7_2	0.1111
p.A1776G	LB771-HNC	upper_aerodigestive_tract	COSMIC	PTPGYE	DEG_SCF_FBW7_2	0.1111
p.R1793Q	SIDM01609	Endometrial Carcinoma	GDSC	PTPGYE	DEG_SCF_FBW7_2	0.2222
p.A1774G	LB771-HNC	upper_aerodigestive_tract	COSMIC	PTPGYE	DEG_SCF_FBW7_2	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P49815	Tuberin	DEG_SCF_FBW7_2	1784:1789	PTPGYE	FBXW7	0.8419	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons