DegronMD

Uniprot ID: Q15149

Source protein: Plectin

Source gene: PLEC

Class: DEG_APCC_DBOX_1

Location: 141:149

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9967

ASA_SCORE: 105.8667

COIL: 0.5306

CONS_SCORE: 0.4207

DSS_SCORE: 0.6103

HELIX: 0.4456

FCONS_SCORE: 1.0359

RIG_SCORE: 0.6993

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P150H	TCGA-F4-6570	COAD	TCGA	RRKELEEVS	DEG_APCC_DBOX_1	0.3056
p.P150H	DO10443	COAD	ICGC	RRKELEEVS	DEG_APCC_DBOX_1	0.3056
p.R147Q	DO219078	BLCA	ICGC	RRKELEEVS	DEG_APCC_DBOX_1	0.7329
p.R147Q	DO220890	MELA	ICGC	RRKELEEVS	DEG_APCC_DBOX_1	0.7329
p.R147Q	PCI-6A	upper_aerodigestive_tract	COSMIC	RRKELEEVS	DEG_APCC_DBOX_1	0.7329
p.T134M	DO222427	BTCA	ICGC	RRKELEEVS	DEG_APCC_DBOX_1	0.1389
p.T134M	DO228475	MALY	ICGC	RRKELEEVS	DEG_APCC_DBOX_1	0.1389
p.E146Q	DO222834	BTCA	ICGC	RRKELEEVS	DEG_APCC_DBOX_1	0.5633
p.R156K	DO219921	DLBC	ICGC	RRKELEEVS	DEG_APCC_DBOX_1	0.1389
p.V148M	DO233109	GACA	ICGC	RRKELEEVS	DEG_APCC_DBOX_1	0.6097
p.R138W	DO228552	LICA	ICGC	RRKELEEVS	DEG_APCC_DBOX_1	0.25
p.A157T	DO48703	LIRI	ICGC	RRKELEEVS	DEG_APCC_DBOX_1	0.1111
p.S136L	DO222638	MELA	ICGC	RRKELEEVS	DEG_APCC_DBOX_1	0.1944
p.R159H	DO232224	PBCA	ICGC	RRKELEEVS	DEG_APCC_DBOX_1	0.5
p.Q144K	DO37715	SKCM	ICGC	RRKELEEVS	DEG_APCC_DBOX_1	0.6944
p.Q144K	DO37444	SKCM	ICGC	RRKELEEVS	DEG_APCC_DBOX_1	0.6944
p.V154E	ACH-000616	Gastric Cancer	CCLE	RRKELEEVS	DEG_APCC_DBOX_1	0.1944
p.E144K	ACH-000763	Myeloma	CCLE	RRKELEEVS	DEG_APCC_DBOX_1	0.591
p.R141P	ACH-000870	Lung Cancer	CCLE	RRKELEEVS	DEG_APCC_DBOX_1	0.6401
p.I137V	MFE-319	endometrium	COSMIC	RRKELEEVS	DEG_APCC_DBOX_1	0.2222
p.D150V	OVMIU	ovary	COSMIC	RRKELEEVS	DEG_APCC_DBOX_1	0.3056
p.V145M	SW620	large_intestine	COSMIC	RRKELEEVS	DEG_APCC_DBOX_1	0.7208
p.R157Q	PCI-6A	upper_aerodigestive_tract	COSMIC	RRKELEEVS	DEG_APCC_DBOX_1	0.1111
p.I141V	MFE-319	endometrium	COSMIC	RRKELEEVS	DEG_APCC_DBOX_1	0.7076
p.Y143C	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	RRKELEEVS	DEG_APCC_DBOX_1	0.7087
p.Y153C	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	RRKELEEVS	DEG_APCC_DBOX_1	0.2222
p.S154T	BHT-101	thyroid	COSMIC	RRKELEEVS	DEG_APCC_DBOX_1	0.1944
p.T152P	OV-56	ovary	COSMIC	RRKELEEVS	DEG_APCC_DBOX_1	0.6944

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: RRKELEEVS

Degron related mutations and impact score

Drug responses associated with PLEC mutations

All proteins holding degron of RRKELEEVS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q15149	Plectin	DEG_APCC_DBOX_1	141:149	RRKELEEVS	APC,CDC20,FZR1	0.9967	More...