DegronMD

Uniprot ID: Q15149

Source protein: Plectin

Source gene: PLEC

Class: LIG_APCC_ABBAyCdc20_2

Location: 4205:4211

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8205

ASA_SCORE: 77.8571

COIL: 0.6881

CONS_SCORE: 0.7464

DSS_SCORE: 0.3361

HELIX: 0.3047

FCONS_SCORE: 0.993

RIG_SCORE: 0.7848

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D4219N	TCGA-24-2288	OV	TCGA	KRGLFDE	LIG_APCC_ABBAyCdc20_2	0.1111
p.D4219N	SIDM01448	Head and Neck Carcinoma	GDSC	KRGLFDE	LIG_APCC_ABBAyCdc20_2	0.1111
p.D4219N	ACH-000500	Head and Neck Cancer	CCLE	KRGLFDE	LIG_APCC_ABBAyCdc20_2	0.1111
p.R4206H	TCGA-A5-A0G2	UCEC	TCGA	KRGLFDE	LIG_APCC_ABBAyCdc20_2	0.7133
p.R4206H	TCGA-BR-8363	STAD	TCGA	KRGLFDE	LIG_APCC_ABBAyCdc20_2	0.7133
p.R4206H	SIDM01050	Biliary Tract Carcinoma	GDSC	KRGLFDE	LIG_APCC_ABBAyCdc20_2	0.7133
p.R4206H	ACH-001494	Bile Duct Cancer	CCLE	KRGLFDE	LIG_APCC_ABBAyCdc20_2	0.7133
p.R4206H	EGI-1	biliary_tract	COSMIC	KRGLFDE	LIG_APCC_ABBAyCdc20_2	0.7133
p.P4199T	TCGA-BR-6458	STAD	TCGA	KRGLFDE	LIG_APCC_ABBAyCdc20_2	0.1667
p.R4197W	TCGA-BR-8363	STAD	TCGA	KRGLFDE	LIG_APCC_ABBAyCdc20_2	0.1111
p.R4197W	SIDM00844	Burkitt's Lymphoma	GDSC	KRGLFDE	LIG_APCC_ABBAyCdc20_2	0.1111
p.R4197W	ACH-000654	Lymphoma	CCLE	KRGLFDE	LIG_APCC_ABBAyCdc20_2	0.1111
p.R4197W	Raji	haematopoietic_and_lymphoid_tissue	COSMIC	KRGLFDE	LIG_APCC_ABBAyCdc20_2	0.1111
p.S4221L	TCGA-BR-A4QL	STAD	TCGA	KRGLFDE	LIG_APCC_ABBAyCdc20_2	0.0556
p.E4212Q	TCGA-FD-A5BX	BLCA	TCGA	KRGLFDE	LIG_APCC_ABBAyCdc20_2	0.3056
p.S4205L	DO51882	BLCA	ICGC	KRGLFDE	LIG_APCC_ABBAyCdc20_2	0.7667
p.S4205L	NALM-6	haematopoietic_and_lymphoid_tissue	COSMIC	KRGLFDE	LIG_APCC_ABBAyCdc20_2	0.7667
p.S4196F	DO514	BLCA	ICGC	KRGLFDE	LIG_APCC_ABBAyCdc20_2	0.0833
p.G4206D	DO222884	COCA	ICGC	KRGLFDE	LIG_APCC_ABBAyCdc20_2	0.7198
p.R4212H	DO52078	HNSC	ICGC	KRGLFDE	LIG_APCC_ABBAyCdc20_2	0.3056
p.R4212H	DO36881	READ	ICGC	KRGLFDE	LIG_APCC_ABBAyCdc20_2	0.3056
p.R4212H	DO47981	STAD	ICGC	KRGLFDE	LIG_APCC_ABBAyCdc20_2	0.3056
p.R4212H	EW-13	bone	COSMIC	KRGLFDE	LIG_APCC_ABBAyCdc20_2	0.3056
p.I4197V	DO219176	LUSC	ICGC	KRGLFDE	LIG_APCC_ABBAyCdc20_2	0.1111
p.S4220F	DO47706	SKCM	ICGC	KRGLFDE	LIG_APCC_ABBAyCdc20_2	0.0833
p.L4208I	SIDM02013	Colorectal Carcinoma	GDSC	KRGLFDE	LIG_APCC_ABBAyCdc20_2	0.6063
p.G4207S	SIDM00545	Melanoma	GDSC	KRGLFDE	LIG_APCC_ABBAyCdc20_2	0.5882
p.G4207S	SIDM00127	Oral Cavity Carcinoma	GDSC	KRGLFDE	LIG_APCC_ABBAyCdc20_2	0.5882
p.G4207S	JHU-022	upper_aerodigestive_tract	COSMIC	KRGLFDE	LIG_APCC_ABBAyCdc20_2	0.5882
p.G4207S	Mewo	skin	COSMIC	KRGLFDE	LIG_APCC_ABBAyCdc20_2	0.5882
p.P4220L	SIDM00177	Melanoma	GDSC	KRGLFDE	LIG_APCC_ABBAyCdc20_2	0.0833
p.P4220L	ACH-002338	Skin Cancer	CCLE	KRGLFDE	LIG_APCC_ABBAyCdc20_2	0.0833
p.P4220L	ACH-002510	Skin Cancer	CCLE	KRGLFDE	LIG_APCC_ABBAyCdc20_2	0.0833
p.I4205V	KYSE-70	oesophagus	COSMIC	KRGLFDE	LIG_APCC_ABBAyCdc20_2	0.7076
p.D4196G	ECC10	stomach	COSMIC	KRGLFDE	LIG_APCC_ABBAyCdc20_2	0.0833
p.S4209L	SNU-C5	large_intestine	COSMIC	KRGLFDE	LIG_APCC_ABBAyCdc20_2	0.7667
p.I4209V	KYSE-70	oesophagus	COSMIC	KRGLFDE	LIG_APCC_ABBAyCdc20_2	0.7076
p.G4204V	NCI-H2342	lung	COSMIC	KRGLFDE	LIG_APCC_ABBAyCdc20_2	0.3056
p.A4201T	AN3-CA	endometrium	COSMIC	KRGLFDE	LIG_APCC_ABBAyCdc20_2	0.2222
p.G4200V	NCI-H2342	lung	COSMIC	KRGLFDE	LIG_APCC_ABBAyCdc20_2	0.1944
p.R4198H	MOLT-16	haematopoietic_and_lymphoid_tissue	COSMIC	KRGLFDE	LIG_APCC_ABBAyCdc20_2	0.1389
p.S4213L	SNU-C5	large_intestine	COSMIC	KRGLFDE	LIG_APCC_ABBAyCdc20_2	0.2778
p.D4200G	ECC10	stomach	COSMIC	KRGLFDE	LIG_APCC_ABBAyCdc20_2	0.1944
p.S4215L	NALM-6	haematopoietic_and_lymphoid_tissue	COSMIC	KRGLFDE	LIG_APCC_ABBAyCdc20_2	0.2222
p.A4211T	AN3-CA	endometrium	COSMIC	KRGLFDE	LIG_APCC_ABBAyCdc20_2	0.7139
p.D4219G	ECC10	stomach	COSMIC	KRGLFDE	LIG_APCC_ABBAyCdc20_2	0.1111
p.A4219T	AN3-CA	endometrium	COSMIC	KRGLFDE	LIG_APCC_ABBAyCdc20_2	0.1111
p.R4202H	MOLT-16	haematopoietic_and_lymphoid_tissue	COSMIC	KRGLFDE	LIG_APCC_ABBAyCdc20_2	0.25
p.R4221H	MOLT-16	haematopoietic_and_lymphoid_tissue	COSMIC	KRGLFDE	LIG_APCC_ABBAyCdc20_2	0.0556

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: KRGLFDE

Degron related mutations and impact score

Drug responses associated with PLEC mutations

All proteins holding degron of KRGLFDE

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q15149	Plectin	LIG_APCC_ABBAyCdc20_2	4205:4211	KRGLFDE	APC,CDC20,FZR1	0.8205	More...