DegronMD - Q6ZVF9(GPRIN3)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G438W	TCGA-09-2044	OV	TCGA	MTPVRE	DEG_SCF_FBW7_2	443:448	Mutation rewiring degron network	0.1944
p.G438W	DO28923	OV	ICGC	MTPVRE	DEG_SCF_FBW7_2	443:448	Mutation rewiring degron network	0.1944
p.G259D	TCGA-28-1757	GBM	TCGA	VTPQPT	DEG_SCF_FBW7_1	263:268	Mutation rewiring degron network	0.2222
p.G259D	DO12166	GBM	ICGC	VTPQPT	DEG_SCF_FBW7_1	263:268	Mutation rewiring degron network	0.2222
p.E188D	TCGA-43-2576	LUSC	TCGA	VLSSS	DEG_SPOP_SBC_1	177:181	Mutation rewiring degron network	0.1389
p.E188D	DO27005	LUSC	ICGC	VLSSS	DEG_SPOP_SBC_1	177:181	Mutation rewiring degron network	0.1389
p.L270H	TCGA-60-2711	LUSC	TCGA	VTPQPT	DEG_SCF_FBW7_1	263:268	Mutation rewiring degron network	0.2778
p.L270H	DO26987	LUSC	ICGC	VTPQPT	DEG_SCF_FBW7_1	263:268	Mutation rewiring degron network	0.2778
p.K454E	TCGA-66-2787	LUSC	TCGA	MTPVRE	DEG_SCF_FBW7_2	443:448	Mutation substituting flanking lysine	0.2778
p.K454E	DO26647	LUSC	ICGC	MTPVRE	DEG_SCF_FBW7_2	443:448	Mutation substituting flanking lysine	0.2778
p.A452S	TCGA-78-7146	LUAD	TCGA	MTPVRE	DEG_SCF_FBW7_2	443:448	Mutation rewiring degron network	0.2222
p.A452S	DO23717	LUAD	ICGC	MTPVRE	DEG_SCF_FBW7_2	443:448	Mutation rewiring degron network	0.2222
p.S158L	TCGA-78-7150	LUAD	TCGA	AITSS	DEG_SPOP_SBC_1	145:149	Mutation rewiring degron network	0.0833
p.S158L	DO24411	LUAD	ICGC	AITSS	DEG_SPOP_SBC_1	145:149	Mutation rewiring degron network	0.0833
p.P167H	TCGA-AA-3947	COAD	TCGA	VLSSS	DEG_SPOP_SBC_1	177:181	Mutation rewiring degron network	0.0556
p.P167H	DO8192	COAD	ICGC	VLSSS	DEG_SPOP_SBC_1	177:181	Mutation rewiring degron network	0.0556
p.K182R	TCGA-AG-3731	READ	TCGA	VLSSS	DEG_SPOP_SBC_1	177:181	Mutation rewiring degron network	0.3056
p.K182R	DO36463	READ	ICGC	VLSSS	DEG_SPOP_SBC_1	177:181	Mutation rewiring degron network	0.3056
p.L178V	TCGA-AJ-A3QS	UCEC	TCGA	VLSSS	DEG_SPOP_SBC_1	177:181	Mutation altering degron motif	0.5654
p.L178V	DO41349	UCEC	ICGC	VLSSS	DEG_SPOP_SBC_1	177:181	Mutation altering degron motif	0.5654
p.A456T	TCGA-AP-A1DV	UCEC	TCGA	MTPVRE	DEG_SCF_FBW7_2	443:448	Mutation rewiring degron network	0.1111
p.A456T	DO43186	UCEC	ICGC	MTPVRE	DEG_SCF_FBW7_2	443:448	Mutation rewiring degron network	0.1111
p.S137F	TCGA-AX-A1CE	UCEC	TCGA	AITSS	DEG_SPOP_SBC_1	145:149	Mutation rewiring degron network	0.1111
p.S137F	DO42280	UCEC	ICGC	AITSS	DEG_SPOP_SBC_1	145:149	Mutation rewiring degron network	0.1111
p.D183E	TCGA-AX-A2HC	UCEC	TCGA	VLSSS	DEG_SPOP_SBC_1	177:181	Mutation rewiring degron network	0.2778
p.D183E	DO41572	UCEC	ICGC	VLSSS	DEG_SPOP_SBC_1	177:181	Mutation rewiring degron network	0.2778
p.C277Y	TCGA-B5-A11E	UCEC	TCGA	VTPQPT	DEG_SCF_FBW7_1	263:268	Mutation rewiring degron network	0.0833
p.C277Y	DO41644	UCEC	ICGC	VTPQPT	DEG_SCF_FBW7_1	263:268	Mutation rewiring degron network	0.0833
p.P265H	TCGA-BR-4191	STAD	TCGA	VTPQPT	DEG_SCF_FBW7_1	263:268	Mutation altering degron motif	0.7694
p.P265H	DO38891	STAD	ICGC	VTPQPT	DEG_SCF_FBW7_1	263:268	Mutation altering degron motif	0.7694
p.D183A	TCGA-CD-8529	STAD	TCGA	VLSSS	DEG_SPOP_SBC_1	177:181	Mutation rewiring degron network	0.2778
p.D183A	DO47753	STAD	ICGC	VLSSS	DEG_SPOP_SBC_1	177:181	Mutation rewiring degron network	0.2778
p.G259C	TCGA-D3-A2JP	SKCM	TCGA	VTPQPT	DEG_SCF_FBW7_1	263:268	Mutation rewiring degron network	0.2222
p.G259C	DO47407	SKCM	ICGC	VTPQPT	DEG_SCF_FBW7_1	263:268	Mutation rewiring degron network	0.2222
p.S154F	TCGA-D3-A5GU	SKCM	TCGA	AITSS	DEG_SPOP_SBC_1	145:149	Mutation rewiring degron network	0.1944
p.S154F	TCGA-IB-7651	PAAD	TCGA	AITSS	DEG_SPOP_SBC_1	145:149	Mutation rewiring degron network	0.1944
p.S154F	DO46657	PAAD	ICGC	AITSS	DEG_SPOP_SBC_1	145:149	Mutation rewiring degron network	0.1944
p.S154F	DO47584	SKCM	ICGC	AITSS	DEG_SPOP_SBC_1	145:149	Mutation rewiring degron network	0.1944
p.S272G	TCGA-DD-AAVR	LIHC	TCGA	VTPQPT	DEG_SCF_FBW7_1	263:268	Mutation rewiring degron network	0.2222
p.S272G	DO52278	LIHC	ICGC	VTPQPT	DEG_SCF_FBW7_1	263:268	Mutation rewiring degron network	0.2222
p.T433M	TCGA-DU-5871	LGG	TCGA	MTPVRE	DEG_SCF_FBW7_2	443:448	Mutation rewiring degron network	0.0556
p.T433M	DO22318	LGG	ICGC	MTPVRE	DEG_SCF_FBW7_2	443:448	Mutation rewiring degron network	0.0556
p.D153H	TCGA-FD-A43P	BLCA	TCGA	AITSS	DEG_SPOP_SBC_1	145:149	Mutation rewiring degron network	0.2222
p.D153H	DO44049	BLCA	ICGC	AITSS	DEG_SPOP_SBC_1	145:149	Mutation rewiring degron network	0.2222
p.M156I	TCGA-G2-A2EC	BLCA	TCGA	AITSS	DEG_SPOP_SBC_1	145:149	Mutation rewiring degron network	0.1389
p.M156I	DO651	BLCA	ICGC	AITSS	DEG_SPOP_SBC_1	145:149	Mutation rewiring degron network	0.1389
p.P267S	TCGA-GN-A263	SKCM	TCGA	VTPQPT	DEG_SCF_FBW7_1	263:268	Mutation altering degron motif	0.5641
p.P267S	DO37766	SKCM	ICGC	VTPQPT	DEG_SCF_FBW7_1	263:268	Mutation altering degron motif	0.5641
p.E436K	TCGA-IB-7651	PAAD	TCGA	MTPVRE	DEG_SCF_FBW7_2	443:448	Mutation rewiring degron network	0.1389
p.E436K	DO46657	PAAD	ICGC	MTPVRE	DEG_SCF_FBW7_2	443:448	Mutation rewiring degron network	0.1389
p.S275L	TCGA-LH-A9QB	SKCM	TCGA	VTPQPT	DEG_SCF_FBW7_1	263:268	Mutation rewiring degron network	0.1389
p.S275L	DO27879	ORCA	ICGC	VTPQPT	DEG_SCF_FBW7_1	263:268	Mutation rewiring degron network	0.1389
p.S275L	DO51266	SKCM	ICGC	VTPQPT	DEG_SCF_FBW7_1	263:268	Mutation rewiring degron network	0.1389
p.P190L	TCGA-RP-A694	SKCM	TCGA	VLSSS	DEG_SPOP_SBC_1	177:181	Mutation rewiring degron network	0.0833
p.P190L	DO51269	SKCM	ICGC	VLSSS	DEG_SPOP_SBC_1	177:181	Mutation rewiring degron network	0.0833
p.P274S	TCGA-WS-AB45	COAD	TCGA	VTPQPT	DEG_SCF_FBW7_1	263:268	Mutation rewiring degron network	0.1667
p.P274S	DO51734	COAD	ICGC	VTPQPT	DEG_SCF_FBW7_1	263:268	Mutation rewiring degron network	0.1667
p.Q159H	DO48431	BLCA	ICGC	AITSS	DEG_SPOP_SBC_1	145:149	Mutation rewiring degron network	0.0556
p.E449D	DO7801	COAD	ICGC	MTPVRE	DEG_SCF_FBW7_2	443:448	Mutation rewiring degron network	0.3056
p.N144D	DO230323	COCA	ICGC	AITSS	DEG_SPOP_SBC_1	145:149	Mutation rewiring degron network	0.3056
p.V446A	DO230334	COCA	ICGC	MTPVRE	DEG_SCF_FBW7_2	443:448	Mutation altering degron motif	0.5825
p.V446A	DO229013	COCA	ICGC	MTPVRE	DEG_SCF_FBW7_2	443:448	Mutation altering degron motif	0.5825
p.V446A	DO229016	COCA	ICGC	MTPVRE	DEG_SCF_FBW7_2	443:448	Mutation altering degron motif	0.5825
p.V446A	DO229005	COCA	ICGC	MTPVRE	DEG_SCF_FBW7_2	443:448	Mutation altering degron motif	0.5825
p.V446A	DO229047	LICA	ICGC	MTPVRE	DEG_SCF_FBW7_2	443:448	Mutation altering degron motif	0.5825
p.L178I	DO223068	ESCA	ICGC	VLSSS	DEG_SPOP_SBC_1	177:181	Mutation altering degron motif	0.6063
p.V177I	DO231580	LINC	ICGC	VLSSS	DEG_SPOP_SBC_1	177:181	Mutation altering degron motif	0.7076
p.G442E	DO228418	MALY	ICGC	MTPVRE	DEG_SCF_FBW7_2	443:448	Mutation rewiring degron network	0.3056
p.T268A	DO220851	MELA	ICGC	VTPQPT	DEG_SCF_FBW7_1	263:268	Mutation altering degron motif	0.7139
p.E448K	DO220872	MELA	ICGC	MTPVRE	DEG_SCF_FBW7_2	443:448	Mutation altering degron motif	0.7022
p.S262F	DO232761	PBCA	ICGC	VTPQPT	DEG_SCF_FBW7_1	263:268	Mutation rewiring degron network	0.3056
p.K435N	SIDM00962	Chronic Myelogenous Leukemia	GDSC	MTPVRE	DEG_SCF_FBW7_2	443:448	Mutation substituting flanking lysine	0.2222
p.K435N	BV-173	haematopoietic and lymphoid tissue	COSMIC	MTPVRE	DEG_SCF_FBW7_2	443:448	Mutation substituting flanking lysine	0.2222
p.E448V	SIDM00119	Non-Small Cell Lung Carcinoma	GDSC	MTPVRE	DEG_SCF_FBW7_2	443:448	Mutation altering degron motif	0.7693
p.E448V	ACH-000706	Lung Cancer	CCLE	MTPVRE	DEG_SCF_FBW7_2	443:448	Mutation altering degron motif	0.7693
p.E448V	EKVX	lung	COSMIC	MTPVRE	DEG_SCF_FBW7_2	443:448	Mutation altering degron motif	0.7693
p.R439K	SIDM00855	Other Sarcomas	GDSC	MTPVRE	DEG_SCF_FBW7_2	443:448	Mutation rewiring degron network	0.2222
p.R439K	SIDM00529	Breast Carcinoma	GDSC	MTPVRE	DEG_SCF_FBW7_2	443:448	Mutation rewiring degron network	0.2222
p.R439K	SIDM00650	Small Cell Lung Carcinoma	GDSC	MTPVRE	DEG_SCF_FBW7_2	443:448	Mutation rewiring degron network	0.2222
p.R439K	SIDM00694	Other Solid Cancers	GDSC	MTPVRE	DEG_SCF_FBW7_2	443:448	Mutation rewiring degron network	0.2222
p.R439K	SIDM00879	Breast Carcinoma	GDSC	MTPVRE	DEG_SCF_FBW7_2	443:448	Mutation rewiring degron network	0.2222
p.R439K	SIDM00844	Burkitt's Lymphoma	GDSC	MTPVRE	DEG_SCF_FBW7_2	443:448	Mutation rewiring degron network	0.2222
p.R439K	SIDM00793	Burkitt's Lymphoma	GDSC	MTPVRE	DEG_SCF_FBW7_2	443:448	Mutation rewiring degron network	0.2222
p.R439K	SIDM00863	Burkitt's Lymphoma	GDSC	MTPVRE	DEG_SCF_FBW7_2	443:448	Mutation rewiring degron network	0.2222
p.R439K	SIDM01681	Non-Cancerous	GDSC	MTPVRE	DEG_SCF_FBW7_2	443:448	Mutation rewiring degron network	0.2222
p.R439K	SIDM00721	Small Cell Lung Carcinoma	GDSC	MTPVRE	DEG_SCF_FBW7_2	443:448	Mutation rewiring degron network	0.2222
p.R439K	SIDM01677	Non-Small Cell Lung Carcinoma	GDSC	MTPVRE	DEG_SCF_FBW7_2	443:448	Mutation rewiring degron network	0.2222
p.R439K	SIDM01525	Acute Myeloid Leukemia	GDSC	MTPVRE	DEG_SCF_FBW7_2	443:448	Mutation rewiring degron network	0.2222
p.S180G	SIDM00746	Non-Small Cell Lung Carcinoma	GDSC	VLSSS	DEG_SPOP_SBC_1	177:181	Mutation altering degron motif	0.6993
p.S180G	SIDM00138	Non-Small Cell Lung Carcinoma	GDSC	VLSSS	DEG_SPOP_SBC_1	177:181	Mutation altering degron motif	0.6993
p.S180G	SIDM01605	Non-Small Cell Lung Carcinoma	GDSC	VLSSS	DEG_SPOP_SBC_1	177:181	Mutation altering degron motif	0.6993
p.G259S	SIDM00190	Melanoma	GDSC	VTPQPT	DEG_SCF_FBW7_1	263:268	Mutation rewiring degron network	0.2222
p.G259S	ACH-002097	Skin Cancer	CCLE	VTPQPT	DEG_SCF_FBW7_1	263:268	Mutation rewiring degron network	0.2222
p.G259S	CP66-MEL	skin	COSMIC	VTPQPT	DEG_SCF_FBW7_1	263:268	Mutation rewiring degron network	0.2222
p.I146V	SIDM01559	Melanoma	GDSC	AITSS	DEG_SPOP_SBC_1	145:149	Mutation altering degron motif	0.5965
p.I146V	ACH-000274	Skin Cancer	CCLE	AITSS	DEG_SPOP_SBC_1	145:149	Mutation altering degron motif	0.5965

DegronMD: protein-targeted degradation, mutation and drug response to degrons

GPRIN3

UniProt ID: Q6ZVF9

Entrez ID: 285513

Protein name: G protein-regulated inducer of neurite outgrowth 3 (GRIN3)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for GPRIN3 in