DegronMD

Uniprot ID: Q6ZVF9

Source protein: G protein-regulated inducer of neurite outgrowth 3

Source gene: GPRIN3

Class: DEG_SCF_FBW7_2

Location: 443:448

E3 ligase: FBXW7

DEGRON score: 0.7164

ASA_SCORE: 110.2833

COIL: 0.8197

CONS_SCORE: 0.2904

DSS_SCORE: 0.5418

HELIX: 0.0872

FCONS_SCORE: 0.7605

RIG_SCORE: 0.7345

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G438W	TCGA-09-2044	OV	TCGA	MTPVRE	DEG_SCF_FBW7_2	0.1944
p.G438W	DO28923	OV	ICGC	MTPVRE	DEG_SCF_FBW7_2	0.1944
p.K454E	TCGA-66-2787	LUSC	TCGA	MTPVRE	DEG_SCF_FBW7_2	0.2778
p.K454E	DO26647	LUSC	ICGC	MTPVRE	DEG_SCF_FBW7_2	0.2778
p.A452S	TCGA-78-7146	LUAD	TCGA	MTPVRE	DEG_SCF_FBW7_2	0.2222
p.A452S	DO23717	LUAD	ICGC	MTPVRE	DEG_SCF_FBW7_2	0.2222
p.A456T	TCGA-AP-A1DV	UCEC	TCGA	MTPVRE	DEG_SCF_FBW7_2	0.1111
p.A456T	DO43186	UCEC	ICGC	MTPVRE	DEG_SCF_FBW7_2	0.1111
p.T433M	TCGA-DU-5871	LGG	TCGA	MTPVRE	DEG_SCF_FBW7_2	0.0556
p.T433M	DO22318	LGG	ICGC	MTPVRE	DEG_SCF_FBW7_2	0.0556
p.E436K	TCGA-IB-7651	PAAD	TCGA	MTPVRE	DEG_SCF_FBW7_2	0.1389
p.E436K	DO46657	PAAD	ICGC	MTPVRE	DEG_SCF_FBW7_2	0.1389
p.E449D	DO7801	COAD	ICGC	MTPVRE	DEG_SCF_FBW7_2	0.3056
p.V446A	DO230334	COCA	ICGC	MTPVRE	DEG_SCF_FBW7_2	0.5825
p.V446A	DO229013	COCA	ICGC	MTPVRE	DEG_SCF_FBW7_2	0.5825
p.V446A	DO229016	COCA	ICGC	MTPVRE	DEG_SCF_FBW7_2	0.5825
p.V446A	DO229005	COCA	ICGC	MTPVRE	DEG_SCF_FBW7_2	0.5825
p.V446A	DO229047	LICA	ICGC	MTPVRE	DEG_SCF_FBW7_2	0.5825
p.G442E	DO228418	MALY	ICGC	MTPVRE	DEG_SCF_FBW7_2	0.3056
p.E448K	DO220872	MELA	ICGC	MTPVRE	DEG_SCF_FBW7_2	0.7022
p.K435N	SIDM00962	Chronic Myelogenous Leukemia	GDSC	MTPVRE	DEG_SCF_FBW7_2	0.2222
p.K435N	BV-173	haematopoietic_and_lymphoid_tissue	COSMIC	MTPVRE	DEG_SCF_FBW7_2	0.2222
p.E448V	SIDM00119	Non-Small Cell Lung Carcinoma	GDSC	MTPVRE	DEG_SCF_FBW7_2	0.7693
p.E448V	ACH-000706	Lung Cancer	CCLE	MTPVRE	DEG_SCF_FBW7_2	0.7693
p.E448V	EKVX	lung	COSMIC	MTPVRE	DEG_SCF_FBW7_2	0.7693
p.R439K	SIDM00855	Other Sarcomas	GDSC	MTPVRE	DEG_SCF_FBW7_2	0.2222
p.R439K	SIDM00529	Breast Carcinoma	GDSC	MTPVRE	DEG_SCF_FBW7_2	0.2222
p.R439K	SIDM00650	Small Cell Lung Carcinoma	GDSC	MTPVRE	DEG_SCF_FBW7_2	0.2222
p.R439K	SIDM00694	Other Solid Cancers	GDSC	MTPVRE	DEG_SCF_FBW7_2	0.2222
p.R439K	SIDM00879	Breast Carcinoma	GDSC	MTPVRE	DEG_SCF_FBW7_2	0.2222
p.R439K	SIDM00844	Burkitt's Lymphoma	GDSC	MTPVRE	DEG_SCF_FBW7_2	0.2222
p.R439K	SIDM00793	Burkitt's Lymphoma	GDSC	MTPVRE	DEG_SCF_FBW7_2	0.2222
p.R439K	SIDM00863	Burkitt's Lymphoma	GDSC	MTPVRE	DEG_SCF_FBW7_2	0.2222
p.R439K	SIDM01681	Non-Cancerous	GDSC	MTPVRE	DEG_SCF_FBW7_2	0.2222
p.R439K	SIDM00721	Small Cell Lung Carcinoma	GDSC	MTPVRE	DEG_SCF_FBW7_2	0.2222
p.R439K	SIDM01677	Non-Small Cell Lung Carcinoma	GDSC	MTPVRE	DEG_SCF_FBW7_2	0.2222
p.R439K	SIDM01525	Acute Myeloid Leukemia	GDSC	MTPVRE	DEG_SCF_FBW7_2	0.2222

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: MTPVRE

Degron related mutations and impact score

Drug responses associated with GPRIN3 mutations

All proteins holding degron of MTPVRE

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6ZVF9	G protein-regulated inducer of neurite outgrowth 3	DEG_SCF_FBW7_2	443:448	MTPVRE	FBXW7	0.7164	More...