DegronMD

Uniprot ID: Q6ZVF9

Source protein: G protein-regulated inducer of neurite outgrowth 3

Source gene: GPRIN3

Class: DEG_SCF_FBW7_1

Location: 263:268

E3 ligase: FBXW7

DEGRON score: 0.9959

ASA_SCORE: 101.2

COIL: 0.9703

CONS_SCORE: 0.5271

DSS_SCORE: 0.7554

HELIX: 0.0097

FCONS_SCORE: 1.0926

RIG_SCORE: 0.5934

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G259D	TCGA-28-1757	GBM	TCGA	VTPQPT	DEG_SCF_FBW7_1	0.2222
p.G259D	DO12166	GBM	ICGC	VTPQPT	DEG_SCF_FBW7_1	0.2222
p.L270H	TCGA-60-2711	LUSC	TCGA	VTPQPT	DEG_SCF_FBW7_1	0.2778
p.L270H	DO26987	LUSC	ICGC	VTPQPT	DEG_SCF_FBW7_1	0.2778
p.C277Y	TCGA-B5-A11E	UCEC	TCGA	VTPQPT	DEG_SCF_FBW7_1	0.0833
p.C277Y	DO41644	UCEC	ICGC	VTPQPT	DEG_SCF_FBW7_1	0.0833
p.P265H	TCGA-BR-4191	STAD	TCGA	VTPQPT	DEG_SCF_FBW7_1	0.7694
p.P265H	DO38891	STAD	ICGC	VTPQPT	DEG_SCF_FBW7_1	0.7694
p.G259C	TCGA-D3-A2JP	SKCM	TCGA	VTPQPT	DEG_SCF_FBW7_1	0.2222
p.G259C	DO47407	SKCM	ICGC	VTPQPT	DEG_SCF_FBW7_1	0.2222
p.S272G	TCGA-DD-AAVR	LIHC	TCGA	VTPQPT	DEG_SCF_FBW7_1	0.2222
p.S272G	DO52278	LIHC	ICGC	VTPQPT	DEG_SCF_FBW7_1	0.2222
p.P267S	TCGA-GN-A263	SKCM	TCGA	VTPQPT	DEG_SCF_FBW7_1	0.5641
p.P267S	DO37766	SKCM	ICGC	VTPQPT	DEG_SCF_FBW7_1	0.5641
p.S275L	TCGA-LH-A9QB	SKCM	TCGA	VTPQPT	DEG_SCF_FBW7_1	0.1389
p.S275L	DO27879	ORCA	ICGC	VTPQPT	DEG_SCF_FBW7_1	0.1389
p.S275L	DO51266	SKCM	ICGC	VTPQPT	DEG_SCF_FBW7_1	0.1389
p.P274S	TCGA-WS-AB45	COAD	TCGA	VTPQPT	DEG_SCF_FBW7_1	0.1667
p.P274S	DO51734	COAD	ICGC	VTPQPT	DEG_SCF_FBW7_1	0.1667
p.T268A	DO220851	MELA	ICGC	VTPQPT	DEG_SCF_FBW7_1	0.7139
p.S262F	DO232761	PBCA	ICGC	VTPQPT	DEG_SCF_FBW7_1	0.3056
p.G259S	SIDM00190	Melanoma	GDSC	VTPQPT	DEG_SCF_FBW7_1	0.2222
p.G259S	ACH-002097	Skin Cancer	CCLE	VTPQPT	DEG_SCF_FBW7_1	0.2222
p.G259S	CP66-MEL	skin	COSMIC	VTPQPT	DEG_SCF_FBW7_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6ZVF9	G protein-regulated inducer of neurite outgrowth 3	DEG_SCF_FBW7_1	263:268	VTPQPT	FBXW7	0.9959	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons