DegronMD - Q9Y2X9(ZNF281)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.H756N	TCGA-10-0931	OV	TCGA	LTPSQE	DEG_SCF_FBW7_2	759:764	Mutation rewiring degron network	0.25
p.H756N	DO28631	OV	ICGC	LTPSQE	DEG_SCF_FBW7_2	759:764	Mutation rewiring degron network	0.25
p.L752S	TCGA-D9-A6EC	SKCM	TCGA	LTPSQE	DEG_SCF_FBW7_2	759:764	Mutation rewiring degron network	0.1389
p.L752S	DO50291	SKCM	ICGC	LTPSQE	DEG_SCF_FBW7_2	759:764	Mutation rewiring degron network	0.1389
p.L759V	TCGA-W5-AA39	CHOL	TCGA	LTPSQE	DEG_SCF_FBW7_2	759:764	Mutation altering degron motif	0.5654
p.A754G	DO233855	GACA	ICGC	LTPSQE	DEG_SCF_FBW7_2	759:764	Mutation rewiring degron network	0.1944
p.A67E	DO229031	LICA	ICGC	VLSSS	DEG_SPOP_SBC_1	77:81	Mutation rewiring degron network	0.0556
p.H756R	DO229063	LICA	ICGC	LTPSQE	DEG_SCF_FBW7_2	759:764	Mutation rewiring degron network	0.25
p.S69T	SIDM00845	Burkitt's Lymphoma	GDSC	VLSSS	DEG_SPOP_SBC_1	77:81	Mutation rewiring degron network	0.1111
p.T755A	SIDM00354	Squamous Cell Lung Carcinoma	GDSC	LTPSQE	DEG_SCF_FBW7_2	759:764	Mutation rewiring degron network	0.2222
p.T755A	ACH-000442	Lung Cancer	CCLE	LTPSQE	DEG_SCF_FBW7_2	759:764	Mutation rewiring degron network	0.2222
p.T755A	RERF-LC-Sq1	lung	COSMIC	LTPSQE	DEG_SCF_FBW7_2	759:764	Mutation rewiring degron network	0.2222
p.I769M	SIDM00500	Colorectal Carcinoma	GDSC	LTPSQE	DEG_SCF_FBW7_2	759:764	Mutation rewiring degron network	0.1944
p.I769M	ACH-000959	Colon/Colorectal Cancer	CCLE	LTPSQE	DEG_SCF_FBW7_2	759:764	Mutation rewiring degron network	0.1944
p.P74L	ACH-000347	Pancreatic Cancer	CCLE	VLSSS	DEG_SPOP_SBC_1	77:81	Mutation rewiring degron network	0.25
p.A87V	ACH-001690	Head and Neck Cancer	CCLE	VLSSS	DEG_SPOP_SBC_1	77:81	Mutation rewiring degron network	0.1667
p.G766S	Daudi	haematopoietic and lymphoid tissue	COSMIC	LTPSQE	DEG_SCF_FBW7_2	759:764	Mutation rewiring degron network	0.2778

Kaplan plot for ZNF281 in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ZNF281

UniProt ID: Q9Y2X9

Entrez ID: 23528

Protein name: Zinc finger protein 281 (GC-box-binding zinc finger protein 1) (Transcription factor ZBP-99) (Zinc finger DNA-binding protein 99)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for ZNF281 in