DegronMD

Uniprot ID: Q9Y2X9

Source protein: Zinc finger protein 281

Source gene: ZNF281

Class: DEG_SCF_FBW7_2

Location: 759:764

E3 ligase: FBXW7

DEGRON score: 0.9948

ASA_SCORE: 73.7333

COIL: 0.6855

CONS_SCORE: 0.9886

DSS_SCORE: 0.5247

HELIX: 0.2818

FCONS_SCORE: 1.2991

RIG_SCORE: 0.7329

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.H756N	TCGA-10-0931	OV	TCGA	LTPSQE	DEG_SCF_FBW7_2	0.25
p.H756N	DO28631	OV	ICGC	LTPSQE	DEG_SCF_FBW7_2	0.25
p.L752S	TCGA-D9-A6EC	SKCM	TCGA	LTPSQE	DEG_SCF_FBW7_2	0.1389
p.L752S	DO50291	SKCM	ICGC	LTPSQE	DEG_SCF_FBW7_2	0.1389
p.L759V	TCGA-W5-AA39	CHOL	TCGA	LTPSQE	DEG_SCF_FBW7_2	0.5654
p.A754G	DO233855	GACA	ICGC	LTPSQE	DEG_SCF_FBW7_2	0.1944
p.H756R	DO229063	LICA	ICGC	LTPSQE	DEG_SCF_FBW7_2	0.25
p.T755A	SIDM00354	Squamous Cell Lung Carcinoma	GDSC	LTPSQE	DEG_SCF_FBW7_2	0.2222
p.T755A	ACH-000442	Lung Cancer	CCLE	LTPSQE	DEG_SCF_FBW7_2	0.2222
p.T755A	RERF-LC-Sq1	lung	COSMIC	LTPSQE	DEG_SCF_FBW7_2	0.2222
p.I769M	SIDM00500	Colorectal Carcinoma	GDSC	LTPSQE	DEG_SCF_FBW7_2	0.1944
p.I769M	ACH-000959	Colon/Colorectal Cancer	CCLE	LTPSQE	DEG_SCF_FBW7_2	0.1944
p.G766S	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	LTPSQE	DEG_SCF_FBW7_2	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9Y2X9	Zinc finger protein 281	DEG_SCF_FBW7_2	759:764	LTPSQE	FBXW7	0.9948	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons