DegronMD

Uniprot ID: P19484

Source protein: Transcription factor EB

Source gene: TFEB

Class: DEG_SPOP_SBC_1

Location: 130:134

E3 ligase: SPOP

DEGRON score: 0.9904

ASA_SCORE: 67.36

COIL: 0.7788

CONS_SCORE: 0.6673

DSS_SCORE: 0.6111

HELIX: 0.041

FCONS_SCORE: 0.984

RIG_SCORE: 0.5978

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G124V	TCGA-55-A48X	LUAD	TCGA	VLSSS	DEG_SPOP_SBC_1	0.1667
p.G124V	DO24048	LUAD	ICGC	VLSSS	DEG_SPOP_SBC_1	0.1667
p.A135T	TCGA-AP-A1DK	UCEC	TCGA	VLSSS	DEG_SPOP_SBC_1	0.3056
p.A135T	DO233766	GACA	ICGC	VLSSS	DEG_SPOP_SBC_1	0.3056
p.A135T	DO36801	READ	ICGC	VLSSS	DEG_SPOP_SBC_1	0.3056
p.A135T	DO42033	UCEC	ICGC	VLSSS	DEG_SPOP_SBC_1	0.3056
p.A135T	ACH-001049	Lung Cancer	CCLE	VLSSS	DEG_SPOP_SBC_1	0.3056
p.A135T	ACH-002272	Lymphoma	CCLE	VLSSS	DEG_SPOP_SBC_1	0.3056
p.A135T	CPC-N	lung	COSMIC	VLSSS	DEG_SPOP_SBC_1	0.3056
p.A135T	MHH-PREB-1	haematopoietic_and_lymphoid_tissue	COSMIC	VLSSS	DEG_SPOP_SBC_1	0.3056
p.S126Y	DO49755	BLCA	ICGC	VLSSS	DEG_SPOP_SBC_1	0.2222
p.V130M	DO228483	BRCA	ICGC	VLSSS	DEG_SPOP_SBC_1	0.7208
p.A121D	DO233804	GACA	ICGC	VLSSS	DEG_SPOP_SBC_1	0.0833
p.H129N	DO229037	LICA	ICGC	VLSSS	DEG_SPOP_SBC_1	0.3056
p.S133F	DO220859	MELA	ICGC	VLSSS	DEG_SPOP_SBC_1	0.9093
p.V144M	SIDM00216	Colorectal Carcinoma	GDSC	VLSSS	DEG_SPOP_SBC_1	0.0556
p.V144M	SIDM00611	Kidney Carcinoma	GDSC	VLSSS	DEG_SPOP_SBC_1	0.0556
p.V144M	SIDM01197	Colorectal Carcinoma	GDSC	VLSSS	DEG_SPOP_SBC_1	0.0556
p.V144M	SIDM00491	Thyroid Gland Carcinoma	GDSC	VLSSS	DEG_SPOP_SBC_1	0.0556
p.V144M	SIDM01030	Esophageal Squamous Cell Carcinoma	GDSC	VLSSS	DEG_SPOP_SBC_1	0.0556
p.V144M	SIDM00555	Glioblastoma	GDSC	VLSSS	DEG_SPOP_SBC_1	0.0556
p.V144M	SIDM00308	Chronic Myelogenous Leukemia	GDSC	VLSSS	DEG_SPOP_SBC_1	0.0556
p.V144M	SIDM00231	Kidney Carcinoma	GDSC	VLSSS	DEG_SPOP_SBC_1	0.0556
p.V144M	SIDM00569	Osteosarcoma	GDSC	VLSSS	DEG_SPOP_SBC_1	0.0556
p.V144M	SIDM00193	Colorectal Carcinoma	GDSC	VLSSS	DEG_SPOP_SBC_1	0.0556
p.V144M	SIDM00002	Neuroblastoma	GDSC	VLSSS	DEG_SPOP_SBC_1	0.0556
p.V144M	SIDM00301	Pancreatic Carcinoma	GDSC	VLSSS	DEG_SPOP_SBC_1	0.0556
p.V144M	SIDM00351	Oral Cavity Carcinoma	GDSC	VLSSS	DEG_SPOP_SBC_1	0.0556
p.V144M	SIDM00024	Non-Cancerous	GDSC	VLSSS	DEG_SPOP_SBC_1	0.0556
p.V144M	SIDM00498	Colorectal Carcinoma	GDSC	VLSSS	DEG_SPOP_SBC_1	0.0556
p.V144M	SIDM00018	Acute Myeloid Leukemia	GDSC	VLSSS	DEG_SPOP_SBC_1	0.0556
p.V144M	SIDM01031	Esophageal Squamous Cell Carcinoma	GDSC	VLSSS	DEG_SPOP_SBC_1	0.0556
p.V144M	SIDM00233	T-Lymphoblastic Leukemia	GDSC	VLSSS	DEG_SPOP_SBC_1	0.0556
p.V144M	SIDM00316	Glioblastoma	GDSC	VLSSS	DEG_SPOP_SBC_1	0.0556
p.V144M	SIDM01570	Ovarian Carcinoma	GDSC	VLSSS	DEG_SPOP_SBC_1	0.0556
p.V144M	SIDM01412	Oral Cavity Carcinoma	GDSC	VLSSS	DEG_SPOP_SBC_1	0.0556
p.V144M	SIDM01472	Hepatocellular Carcinoma	GDSC	VLSSS	DEG_SPOP_SBC_1	0.0556
p.V144M	SIDM00161	Biliary Tract Carcinoma	GDSC	VLSSS	DEG_SPOP_SBC_1	0.0556
p.V144M	SIDM00163	Biliary Tract Carcinoma	GDSC	VLSSS	DEG_SPOP_SBC_1	0.0556
p.V144M	SIDM01448	Head and Neck Carcinoma	GDSC	VLSSS	DEG_SPOP_SBC_1	0.0556
p.V144M	SIDM01454	Kidney Carcinoma	GDSC	VLSSS	DEG_SPOP_SBC_1	0.0556
p.V144M	SIDM01215	Ovarian Carcinoma	GDSC	VLSSS	DEG_SPOP_SBC_1	0.0556
p.A139V	ACH-000998	Colon/Colorectal Cancer	CCLE	VLSSS	DEG_SPOP_SBC_1	0.1944
p.A139V	CW-2	large_intestine	COSMIC	VLSSS	DEG_SPOP_SBC_1	0.1944
p.G121S	CHL-1	skin	COSMIC	VLSSS	DEG_SPOP_SBC_1	0.0833
p.V122I	NCI-SNU-5	stomach	COSMIC	VLSSS	DEG_SPOP_SBC_1	0.5556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O00182	Galectin-9	DEG_SPOP_SBC_1	37:41	VLSSS	SPOP	0.6739	More...
O00268	Transcription initiation factor TFIID subunit 4	DEG_SPOP_SBC_1	697:701	VLSSS	SPOP	0.7112	More...
O75113	NEDD4-binding protein 1	DEG_SPOP_SBC_1	254:258	VLSSS	SPOP	0.9995	More...
P19484	Transcription factor EB	DEG_SPOP_SBC_1	130:134	VLSSS	SPOP	0.9904	More...
P25054	Adenomatous polyposis coli protein	DEG_SPOP_SBC_1	291:295	VLSSS	SPOP	0.9986	More...
P98175	RNA-binding protein 10	DEG_SPOP_SBC_1	325:329	VLSSS	SPOP	0.7807	More...
Q07890	Son of sevenless homolog 2	DEG_SPOP_SBC_1	1276:1280	VLSSS	SPOP	0.9839	More...
Q14671	Pumilio homolog 1	DEG_SPOP_SBC_1	225:229	VLSSS	SPOP	0.9888	More...
Q15149	Plectin	DEG_SPOP_SBC_1	978:982	VLSSS	SPOP	0.6246	More...
Q15572	TATA box-binding protein-associated factor RNA polymerase I subunit C	DEG_SPOP_SBC_1	854:858	VLSSS	SPOP	0.893	More...
Q6IAA8	Ragulator complex protein LAMTOR1	DEG_SPOP_SBC_1	94:98	VLSSS	SPOP	0.5049	More...
Q6UUV7	CREB-regulated transcription coactivator 3	DEG_SPOP_SBC_1	341:345	VLSSS	SPOP	0.9871	More...
Q86WP2	Vasculin	DEG_SPOP_SBC_1	377:381	VLSSS	SPOP	0.9365	More...
Q8NDX5	Polyhomeotic-like protein 3	DEG_SPOP_SBC_1	225:229	VLSSS	SPOP	0.993	More...
Q8TB72	Pumilio homolog 2	DEG_SPOP_SBC_1	98:102	VLSSS	SPOP	0.9847	More...
Q8TCU4	Alstrom syndrome protein 1	DEG_SPOP_SBC_1	570:574	VLSSS	SPOP	0.9598	More...
Q8WUI4	Histone deacetylase 7	DEG_SPOP_SBC_1	505:509	VLSSS	SPOP	0.9515	More...
Q96EB6	NAD-dependent protein deacetylase sirtuin-1	DEG_SPOP_SBC_1	665:669	VLSSS	SPOP	0.888	More...
Q96IT1	Zinc finger protein 496	DEG_SPOP_SBC_1	356:360	VLSSS	SPOP	0.6662	More...
Q96P47	Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3	DEG_SPOP_SBC_1	526:530	VLSSS	SPOP	0.911	More...
Q96QF0	Rab-3A-interacting protein	DEG_SPOP_SBC_1	259:263	VLSSS	SPOP	0.9939	More...
Q9H329	Band 4.1-like protein 4B	DEG_SPOP_SBC_1	477:481	VLSSS	SPOP	0.9088	More...
Q9H4A3	Serine/threonine-protein kinase WNK1	DEG_SPOP_SBC_1	1894:1898	VLSSS	SPOP	0.9125	More...
Q9NS91	E3 ubiquitin-protein ligase RAD18	DEG_SPOP_SBC_1	430:434	VLSSS	SPOP	0.99	More...
Q9P212	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1	DEG_SPOP_SBC_1	1175:1179	VLSSS	SPOP	0.9697	More...
Q9UKG1	DCC-interacting protein 13-alpha	DEG_SPOP_SBC_1	687:691	VLSSS	SPOP	0.9973	More...
Q9Y2X9	Zinc finger protein 281	DEG_SPOP_SBC_1	77:81	VLSSS	SPOP	0.9826	More...
A6NMB1	Sialic acid-binding Ig-like lectin 16	DEG_SPOP_SBC_1	277:281	VLSSS	SPOP	0.7762	More...
P17098	Zinc finger protein 8	DEG_SPOP_SBC_1	183:187	VLSSS	SPOP	0.9973	More...
Q3B8N2	Galectin-9B	DEG_SPOP_SBC_1	37:41	VLSSS	SPOP	0.6051	More...
Q8N442	Translation factor GUF1, mitochondrial	DEG_SPOP_SBC_1	437:441	VLSSS	SPOP	0.5017	More...
Q6ZVF9	G protein-regulated inducer of neurite outgrowth 3	DEG_SPOP_SBC_1	177:181	VLSSS	SPOP	0.8195	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VLSSS

Degron related mutations and impact score

Drug responses associated with TFEB mutations

All proteins holding degron of VLSSS