DegronMD

Uniprot ID: Q8TCU4

Source protein: Alstrom syndrome protein 1

Source gene: ALMS1

Class: DEG_SCF_FBW7_1

Location: 1466:1472

E3 ligase: FBXW7

DEGRON score: 0.9857

ASA_SCORE: 80.9571

COIL: 0.9127

CONS_SCORE: 0.2738

DSS_SCORE: 0.5917

HELIX: 0.0121

FCONS_SCORE: 1

RIG_SCORE: 0.6935

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T1464M	TCGA-BS-A0UL	UCEC	TCGA	IGTPTVT	DEG_SCF_FBW7_1	0.2778
p.A1457S	TCGA-CC-A5UD	LIHC	TCGA	IGTPTVT	DEG_SCF_FBW7_1	0.0833
p.A1457S	DO219552	LIHC	ICGC	IGTPTVT	DEG_SCF_FBW7_1	0.0833
p.G1466D	TCGA-E6-A1LX	UCEC	TCGA	IGTPTVT	DEG_SCF_FBW7_1	0.7198
p.G1466D	DO41020	UCEC	ICGC	IGTPTVT	DEG_SCF_FBW7_1	0.7198
p.G1466D	ACH-000299	Leukemia	CCLE	IGTPTVT	DEG_SCF_FBW7_1	0.7198
p.P1473L	TCGA-YD-A9TA	SKCM	TCGA	IGTPTVT	DEG_SCF_FBW7_1	0.3056
p.P1473L	DO219503	SKCM	ICGC	IGTPTVT	DEG_SCF_FBW7_1	0.3056
p.S1475R	DO225322	BRCA	ICGC	IGTPTVT	DEG_SCF_FBW7_1	0.25
p.S1479F	DO37819	SKCM	ICGC	IGTPTVT	DEG_SCF_FBW7_1	0.1389
p.P1478L	DO38099	SKCM	ICGC	IGTPTVT	DEG_SCF_FBW7_1	0.1667
p.T1470N	SIDM00561	Other Blood Cancers	GDSC	IGTPTVT	DEG_SCF_FBW7_1	0.5944
p.T1470N	MLMA	haematopoietic_and_lymphoid_tissue	COSMIC	IGTPTVT	DEG_SCF_FBW7_1	0.5944
p.T1469N	ACH-002274	Leukemia	CCLE	IGTPTVT	DEG_SCF_FBW7_1	0.7055
p.T1475A	RERF-LC-Sq1	lung	COSMIC	IGTPTVT	DEG_SCF_FBW7_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8TCU4	Alstrom syndrome protein 1	DEG_SCF_FBW7_1	1466:1472	IGTPTVT	FBXW7	0.9857	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons