DegronMD

Uniprot ID: Q8TCU4

Source protein: Alstrom syndrome protein 1

Source gene: ALMS1

Class: DEG_SPOP_SBC_1

Location: 1376:1380

E3 ligase: SPOP

DEGRON score: 0.995

ASA_SCORE: 81.86

COIL: 0.8884

CONS_SCORE: 0.5621

DSS_SCORE: 0.6326

HELIX: 0.0234

FCONS_SCORE: 1.1641

RIG_SCORE: 0.6877

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G1371D	TCGA-D7-A4YY	STAD	TCGA	VTSTS	DEG_SPOP_SBC_1	0.1944
p.G1371D	DO47733	STAD	ICGC	VTSTS	DEG_SPOP_SBC_1	0.1944
p.S1388N	TCGA-EE-A2MC	SKCM	TCGA	VTSTS	DEG_SPOP_SBC_1	0.1111
p.S1388N	DO232761	PBCA	ICGC	VTSTS	DEG_SPOP_SBC_1	0.1111
p.S1388N	DO37559	SKCM	ICGC	VTSTS	DEG_SPOP_SBC_1	0.1111
p.S1388N	ACH-001203	Lymphoma	CCLE	VTSTS	DEG_SPOP_SBC_1	0.1111
p.P1387L	TCGA-KK-A59V	PRAD	TCGA	VTSTS	DEG_SPOP_SBC_1	0.25
p.P1387L	DO51346	PRAD	ICGC	VTSTS	DEG_SPOP_SBC_1	0.25
p.P1387L	ACH-000674	Gastric Cancer	CCLE	VTSTS	DEG_SPOP_SBC_1	0.25
p.R1374Q	DO227513	LAML	ICGC	VTSTS	DEG_SPOP_SBC_1	0.2778
p.G1370V	DO228952	LICA	ICGC	VTSTS	DEG_SPOP_SBC_1	0.1667
p.T1374A	DO229055	LICA	ICGC	VTSTS	DEG_SPOP_SBC_1	0.2778
p.H1388R	DO41644	UCEC	ICGC	VTSTS	DEG_SPOP_SBC_1	0.1111
p.E1390G	DO41199	UCEC	ICGC	VTSTS	DEG_SPOP_SBC_1	0.0556
p.S1389N	SIDM00422	Hodgkin's Lymphoma	GDSC	VTSTS	DEG_SPOP_SBC_1	0.0833
p.S1389N	SUP-HD1	haematopoietic_and_lymphoid_tissue	COSMIC	VTSTS	DEG_SPOP_SBC_1	0.0833
p.P1388L	SIDM00570	Gastric Carcinoma	GDSC	VTSTS	DEG_SPOP_SBC_1	0.1111
p.P1388L	NUGC-4	stomach	COSMIC	VTSTS	DEG_SPOP_SBC_1	0.1111
p.T1385R	SIDM01015	Chronic Myelogenous Leukemia	GDSC	VTSTS	DEG_SPOP_SBC_1	0.1944
p.T1385R	SIDM00845	Burkitt's Lymphoma	GDSC	VTSTS	DEG_SPOP_SBC_1	0.1944
p.T1385R	SIDM00200	Ewing's Sarcoma	GDSC	VTSTS	DEG_SPOP_SBC_1	0.1944
p.T1385R	SIDM00878	Breast Carcinoma	GDSC	VTSTS	DEG_SPOP_SBC_1	0.1944
p.T1385R	SIDM00114	Non-Small Cell Lung Carcinoma	GDSC	VTSTS	DEG_SPOP_SBC_1	0.1944
p.T1385R	SIDM00849	Kidney Carcinoma	GDSC	VTSTS	DEG_SPOP_SBC_1	0.1944
p.T1385R	SIDM00956	Esophageal Squamous Cell Carcinoma	GDSC	VTSTS	DEG_SPOP_SBC_1	0.1944
p.P1383L	SW684	soft_tissue	COSMIC	VTSTS	DEG_SPOP_SBC_1	0.25
p.A1368S	Capan-2	pancreas	COSMIC	VTSTS	DEG_SPOP_SBC_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A1A519	Protein FAM170A	DEG_SPOP_SBC_1	51:55	VTSTS	SPOP	0.8827	More...
O75475	PC4 and SFRS1-interacting protein	DEG_SPOP_SBC_1	269:273	VTSTS	SPOP	0.9904	More...
P35638	DNA damage-inducible transcript 3 protein	DEG_SPOP_SBC_1	73:77	VTSTS	SPOP	0.8287	More...
Q01546	Keratin, type II cytoskeletal 2 oral	DEG_SPOP_SBC_1	512:516	VTSTS	SPOP	0.6377	More...
Q02505	Mucin-3A	DEG_SPOP_SBC_1	804:808	VTSTS	SPOP	0.8927	More...
Q02505	Mucin-3A	DEG_SPOP_SBC_1	1557:1561	VTSTS	SPOP	0.8949	More...
Q14966	Zinc finger protein 638	DEG_SPOP_SBC_1	787:791	VTSTS	SPOP	0.9967	More...
Q6W4X9	Mucin-6	DEG_SPOP_SBC_1	1761:1765	VTSTS	SPOP	0.5627	More...
Q7Z7A1	Centriolin	DEG_SPOP_SBC_1	2288:2292	VTSTS	SPOP	0.8742	More...
Q8IZF6	Adhesion G-protein coupled receptor G4	DEG_SPOP_SBC_1	1248:1252	VTSTS	SPOP	0.959	More...
Q8TCU4	Alstrom syndrome protein 1	DEG_SPOP_SBC_1	1139:1143	VTSTS	SPOP	0.9584	More...
Q8TCU4	Alstrom syndrome protein 1	DEG_SPOP_SBC_1	1376:1380	VTSTS	SPOP	0.995	More...
Q8TCU4	Alstrom syndrome protein 1	DEG_SPOP_SBC_1	1801:1805	VTSTS	SPOP	0.9919	More...
Q96T58	Msx2-interacting protein	DEG_SPOP_SBC_1	2549:2553	VTSTS	SPOP	0.9158	More...
Q9H2X6	Homeodomain-interacting protein kinase 2	DEG_SPOP_SBC_1	1006:1010	VTSTS	SPOP	0.8996	More...
Q8NET4	Retrotransposon Gag-like protein 9	DEG_SPOP_SBC_1	870:874	VTSTS	SPOP	0.9347	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VTSTS

Degron related mutations and impact score

Drug responses associated with ALMS1 mutations

All proteins holding degron of VTSTS