DegronMD

Uniprot ID: Q8TCU4

Source protein: Alstrom syndrome protein 1

Source gene: ALMS1

Class: DEG_SPOP_SBC_1

Location: 1139:1143

E3 ligase: SPOP

DEGRON score: 0.9584

ASA_SCORE: 83.12

COIL: 0.9034

CONS_SCORE: 0.6096

DSS_SCORE: 0.6785

HELIX: 0.0258

FCONS_SCORE: 1.2035

RIG_SCORE: 0.6753

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K1149N	TCGA-17-Z030	LUAD	TCGA	VTSTS	DEG_SPOP_SBC_1	0.1667
p.T1137I	TCGA-AP-A059	UCEC	TCGA	VTSTS	DEG_SPOP_SBC_1	0.2778
p.G1134S	TCGA-BR-4368	STAD	TCGA	VTSTS	DEG_SPOP_SBC_1	0.1944
p.G1134S	DO38715	STAD	ICGC	VTSTS	DEG_SPOP_SBC_1	0.1944
p.T1141I	TCGA-DU-6392	LGG	TCGA	VTSTS	DEG_SPOP_SBC_1	0.7078
p.T1141I	DO22237	LGG	ICGC	VTSTS	DEG_SPOP_SBC_1	0.7078
p.T1141I	ACH-000548	Head and Neck Cancer	CCLE	VTSTS	DEG_SPOP_SBC_1	0.7078
p.P1150S	TCGA-QF-A5YS	UCEC	TCGA	VTSTS	DEG_SPOP_SBC_1	0.25
p.P1150S	DO52426	UCEC	ICGC	VTSTS	DEG_SPOP_SBC_1	0.25
p.D1130N	DO222768	BTCA	ICGC	VTSTS	DEG_SPOP_SBC_1	0.0833
p.Q1131K	DO231954	LICA	ICGC	VTSTS	DEG_SPOP_SBC_1	0.1111
p.G1134V	DO228971	LICA	ICGC	VTSTS	DEG_SPOP_SBC_1	0.1944
p.R1143K	DO36556	READ	ICGC	VTSTS	DEG_SPOP_SBC_1	0.7237
p.T1142I	SIDM00986	Head and Neck Carcinoma	GDSC	VTSTS	DEG_SPOP_SBC_1	0.7078
p.T1142I	BHY	upper_aerodigestive_tract	COSMIC	VTSTS	DEG_SPOP_SBC_1	0.7078
p.T1148A	PWR-1E	prostate	COSMIC	VTSTS	DEG_SPOP_SBC_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A1A519	Protein FAM170A	DEG_SPOP_SBC_1	51:55	VTSTS	SPOP	0.8827	More...
O75475	PC4 and SFRS1-interacting protein	DEG_SPOP_SBC_1	269:273	VTSTS	SPOP	0.9904	More...
P35638	DNA damage-inducible transcript 3 protein	DEG_SPOP_SBC_1	73:77	VTSTS	SPOP	0.8287	More...
Q01546	Keratin, type II cytoskeletal 2 oral	DEG_SPOP_SBC_1	512:516	VTSTS	SPOP	0.6377	More...
Q02505	Mucin-3A	DEG_SPOP_SBC_1	804:808	VTSTS	SPOP	0.8927	More...
Q02505	Mucin-3A	DEG_SPOP_SBC_1	1557:1561	VTSTS	SPOP	0.8949	More...
Q14966	Zinc finger protein 638	DEG_SPOP_SBC_1	787:791	VTSTS	SPOP	0.9967	More...
Q6W4X9	Mucin-6	DEG_SPOP_SBC_1	1761:1765	VTSTS	SPOP	0.5627	More...
Q7Z7A1	Centriolin	DEG_SPOP_SBC_1	2288:2292	VTSTS	SPOP	0.8742	More...
Q8IZF6	Adhesion G-protein coupled receptor G4	DEG_SPOP_SBC_1	1248:1252	VTSTS	SPOP	0.959	More...
Q8TCU4	Alstrom syndrome protein 1	DEG_SPOP_SBC_1	1139:1143	VTSTS	SPOP	0.9584	More...
Q8TCU4	Alstrom syndrome protein 1	DEG_SPOP_SBC_1	1376:1380	VTSTS	SPOP	0.995	More...
Q8TCU4	Alstrom syndrome protein 1	DEG_SPOP_SBC_1	1801:1805	VTSTS	SPOP	0.9919	More...
Q96T58	Msx2-interacting protein	DEG_SPOP_SBC_1	2549:2553	VTSTS	SPOP	0.9158	More...
Q9H2X6	Homeodomain-interacting protein kinase 2	DEG_SPOP_SBC_1	1006:1010	VTSTS	SPOP	0.8996	More...
Q8NET4	Retrotransposon Gag-like protein 9	DEG_SPOP_SBC_1	870:874	VTSTS	SPOP	0.9347	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons