DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
VTSTS
Uniprot ID:
P35638
Source protein:
DNA damage-inducible transcript 3 protein
Source gene:
DDIT3
Class:
DEG_SPOP_SBC_1
Location:
73:77
E3 ligase:
SPOP
DEGRON score:
0.8287
ASA_SCORE:
74.84
COIL:
0.791
CONS_SCORE:
0.552
DSS_SCORE:
0.9011
HELIX:
0.0824
FCONS_SCORE:
0.9541
RIG_SCORE:
0.5698
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with DDIT3 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of VTSTS
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
A1A519
Protein FAM170A
DEG_SPOP_SBC_1
51:55
VTSTS
SPOP
0.8827
More...
O75475
PC4 and SFRS1-interacting protein
DEG_SPOP_SBC_1
269:273
VTSTS
SPOP
0.9904
More...
P35638
DNA damage-inducible transcript 3 protein
DEG_SPOP_SBC_1
73:77
VTSTS
SPOP
0.8287
More...
Q01546
Keratin, type II cytoskeletal 2 oral
DEG_SPOP_SBC_1
512:516
VTSTS
SPOP
0.6377
More...
Q02505
Mucin-3A
DEG_SPOP_SBC_1
804:808
VTSTS
SPOP
0.8927
More...
Q02505
Mucin-3A
DEG_SPOP_SBC_1
1557:1561
VTSTS
SPOP
0.8949
More...
Q14966
Zinc finger protein 638
DEG_SPOP_SBC_1
787:791
VTSTS
SPOP
0.9967
More...
Q6W4X9
Mucin-6
DEG_SPOP_SBC_1
1761:1765
VTSTS
SPOP
0.5627
More...
Q7Z7A1
Centriolin
DEG_SPOP_SBC_1
2288:2292
VTSTS
SPOP
0.8742
More...
Q8IZF6
Adhesion G-protein coupled receptor G4
DEG_SPOP_SBC_1
1248:1252
VTSTS
SPOP
0.959
More...
Q8TCU4
Alstrom syndrome protein 1
DEG_SPOP_SBC_1
1139:1143
VTSTS
SPOP
0.9584
More...
Q8TCU4
Alstrom syndrome protein 1
DEG_SPOP_SBC_1
1376:1380
VTSTS
SPOP
0.995
More...
Q8TCU4
Alstrom syndrome protein 1
DEG_SPOP_SBC_1
1801:1805
VTSTS
SPOP
0.9919
More...
Q96T58
Msx2-interacting protein
DEG_SPOP_SBC_1
2549:2553
VTSTS
SPOP
0.9158
More...
Q9H2X6
Homeodomain-interacting protein kinase 2
DEG_SPOP_SBC_1
1006:1010
VTSTS
SPOP
0.8996
More...
Q8NET4
Retrotransposon Gag-like protein 9
DEG_SPOP_SBC_1
870:874
VTSTS
SPOP
0.9347
More...