DegronMD

Uniprot ID: Q6W4X9

Source protein: Mucin-6

Source gene: MUC6

Class: DEG_SPOP_SBC_1

Location: 1761:1765

E3 ligase: SPOP

DEGRON score: 0.5627

ASA_SCORE: 86.2

COIL: 0.894

CONS_SCORE: 0.2719

DSS_SCORE: 0.6789

HELIX: 0.0208

FCONS_SCORE: 0.9957

RIG_SCORE: 0.6171

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S1765F	TCGA-FD-A3NA	BLCA	TCGA	VTSTS	DEG_SPOP_SBC_1	0.7982
p.S1765F	DO602	BLCA	ICGC	VTSTS	DEG_SPOP_SBC_1	0.7982
p.S1763P	DO222798	COCA	ICGC	VTSTS	DEG_SPOP_SBC_1	0.6752
p.S1763P	DO229010	COCA	ICGC	VTSTS	DEG_SPOP_SBC_1	0.6752
p.S1763P	DO229016	COCA	ICGC	VTSTS	DEG_SPOP_SBC_1	0.6752
p.S1763P	DO229003	COCA	ICGC	VTSTS	DEG_SPOP_SBC_1	0.6752
p.S1763P	DO229005	COCA	ICGC	VTSTS	DEG_SPOP_SBC_1	0.6752
p.S1763P	DO50981	LAML	ICGC	VTSTS	DEG_SPOP_SBC_1	0.6752
p.E1760K	TCGA-DX-A7EU	SARC	TCGA	VTSTS	DEG_SPOP_SBC_1	0.3056
p.E1760K	DO45119	LIRI	ICGC	VTSTS	DEG_SPOP_SBC_1	0.3056
p.E1760K	DO220040	SARC	ICGC	VTSTS	DEG_SPOP_SBC_1	0.3056
p.E1760A	DO222471	COCA	ICGC	VTSTS	DEG_SPOP_SBC_1	0.3056
p.E1760A	DO222703	COCA	ICGC	VTSTS	DEG_SPOP_SBC_1	0.3056
p.S1768T	DO224775	COCA	ICGC	VTSTS	DEG_SPOP_SBC_1	0.25
p.S1768T	DO222480	COCA	ICGC	VTSTS	DEG_SPOP_SBC_1	0.25
p.S1768T	DO229010	COCA	ICGC	VTSTS	DEG_SPOP_SBC_1	0.25
p.S1768T	DO229016	COCA	ICGC	VTSTS	DEG_SPOP_SBC_1	0.25
p.S1768T	DO52338	LUSC	ICGC	VTSTS	DEG_SPOP_SBC_1	0.25
p.H1758Y	DO224801	COCA	ICGC	VTSTS	DEG_SPOP_SBC_1	0.25
p.H1758Y	DO229016	COCA	ICGC	VTSTS	DEG_SPOP_SBC_1	0.25
p.H1758Y	DO229003	COCA	ICGC	VTSTS	DEG_SPOP_SBC_1	0.25
p.H1758Y	DO229211	THCA	ICGC	VTSTS	DEG_SPOP_SBC_1	0.25
p.S1768N	DO222894	COCA	ICGC	VTSTS	DEG_SPOP_SBC_1	0.25
p.P1771S	DO231165	LUSC	ICGC	VTSTS	DEG_SPOP_SBC_1	0.1667
p.P1771S	SIDM00262	Ewing's Sarcoma	GDSC	VTSTS	DEG_SPOP_SBC_1	0.1667

Showing 1 to 25 of 40 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8IZF6	Adhesion G-protein coupled receptor G4	DEG_SPOP_SBC_1	1248:1252	VTSTS	SPOP	0.959	More...
Q8TCU4	Alstrom syndrome protein 1	DEG_SPOP_SBC_1	1139:1143	VTSTS	SPOP	0.9584	More...
Q8TCU4	Alstrom syndrome protein 1	DEG_SPOP_SBC_1	1376:1380	VTSTS	SPOP	0.995	More...
Q8TCU4	Alstrom syndrome protein 1	DEG_SPOP_SBC_1	1801:1805	VTSTS	SPOP	0.9919	More...
Q7Z7A1	Centriolin	DEG_SPOP_SBC_1	2288:2292	VTSTS	SPOP	0.8742	More...
P35638	DNA damage-inducible transcript 3 protein	DEG_SPOP_SBC_1	73:77	VTSTS	SPOP	0.8287	More...
Q9H2X6	Homeodomain-interacting protein kinase 2	DEG_SPOP_SBC_1	1006:1010	VTSTS	SPOP	0.8996	More...
Q01546	Keratin, type II cytoskeletal 2 oral	DEG_SPOP_SBC_1	512:516	VTSTS	SPOP	0.6377	More...
Q96T58	Msx2-interacting protein	DEG_SPOP_SBC_1	2549:2553	VTSTS	SPOP	0.9158	More...
Q02505	Mucin-3A	DEG_SPOP_SBC_1	804:808	VTSTS	SPOP	0.8927	More...
Q02505	Mucin-3A	DEG_SPOP_SBC_1	1557:1561	VTSTS	SPOP	0.8949	More...
Q6W4X9	Mucin-6	DEG_SPOP_SBC_1	1761:1765	VTSTS	SPOP	0.5627	More...
O75475	PC4 and SFRS1-interacting protein	DEG_SPOP_SBC_1	269:273	VTSTS	SPOP	0.9904	More...
A1A519	Protein FAM170A	DEG_SPOP_SBC_1	51:55	VTSTS	SPOP	0.8827	More...
Q8NET4	Retrotransposon Gag-like protein 9	DEG_SPOP_SBC_1	870:874	VTSTS	SPOP	0.9347	More...
Q14966	Zinc finger protein 638	DEG_SPOP_SBC_1	787:791	VTSTS	SPOP	0.9967	More...

Showing 1 to 16 of 16 entries

DegronMD: protein-targeted degradation, mutation and drug response to degrons