DegronMD

Uniprot ID: Q9H2X6

Source protein: Homeodomain-interacting protein kinase 2

Source gene: HIPK2

Class: DEG_SPOP_SBC_1

Location: 1006:1010

E3 ligase: SPOP

DEGRON score: 0.8996

ASA_SCORE: 89.46

COIL: 0.953

CONS_SCORE: 0.3047

DSS_SCORE: 0.6182

HELIX: 0.0186

FCONS_SCORE: 0.9782

RIG_SCORE: 0.5359

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V1006M	TCGA-EC-A1QX	UCEC	TCGA	VTSTS	DEG_SPOP_SBC_1	0.7208
p.V1006M	DO42592	UCEC	ICGC	VTSTS	DEG_SPOP_SBC_1	0.7208
p.G1011S	DO233259	GACA	ICGC	VTSTS	DEG_SPOP_SBC_1	0.3056
p.T1009N	DO228948	LICA	ICGC	VTSTS	DEG_SPOP_SBC_1	0.7055
p.S1002Y	SIDM00799	Glioblastoma	GDSC	VTSTS	DEG_SPOP_SBC_1	0.2222
p.S1002Y	ACH-000558	Brain Cancer	CCLE	VTSTS	DEG_SPOP_SBC_1	0.2222
p.S1002Y	A172	central_nervous_system	COSMIC	VTSTS	DEG_SPOP_SBC_1	0.2222

Drug responses associated with HIPK2 mutations

Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
SIDM00926	UNCLASSIFIED\|lung_NSCLC_not_specified	p.E136D (No)	GDSC	PI-103	186.6479
SIDM00951	LAML\|acute_myeloid_leukaemia	p.D502N (No)	GDSC	PI-103	1.081
SIDM00951	LAML\|acute_myeloid_leukaemia	p.I227T (No)	GDSC	PI-103	1.081
SIDM00939	UNCLASSIFIED\|lung_NSCLC_not_specified	p.G1184V (No)	GDSC	PI-103	0.1231
SIDM00680	COREAD\|large_intestine	p.R554Q (No)	GDSC	PI-103	131.335
SIDM01045	UCEC\|endometrium	p.L59fs*56 (No)	GDSC	PI-103	3.7811
SIDM00499	PRAD\|prostate	p.G45D (No)	GDSC	PI-103	0.3537
SIDM00145	ALL\|lymphoblastic_leukemia	p.N914K (No)	GDSC	PI-103	0.1685
SIDM00108	SKCM\|melanoma	p.H322Q (No)	GDSC	PI-103	2.1752
SIDM00351	HNSC\|head_and_neck	p.R868W (No)	GDSC	PI-103	1.0036
SIDM00976	SKCM\|melanoma	p.G348R (No)	GDSC	PI-103	0.2229
SIDM00045	STAD\|stomach	p.C658F (No)	GDSC	PI-103	0.7557
SIDM01107	SKCM\|melanoma	p.T602P (No)	GDSC	PI-103	57.4273
SIDM01007	ALL\|lymphoblastic_leukemia	p.H807R (No)	GDSC	PI-103	0.2023
SIDM01007	ALL\|lymphoblastic_leukemia	p.K805R (No)	GDSC	PI-103	0.2023
SIDM01073	UNCLASSIFIED\|hairy_cell_leukaemia	p.S142N (No)	GDSC	PI-103	0.2031
SIDM00742	LUAD\|lung_NSCLC_adenocarcinoma	p.H760R (No)	GDSC	PI-103	2.0651
SIDM00565	HNSC\|head_and_neck	p.V737M (No)	GDSC	PI-103	2.2952
SIDM00443	DLBC\|B_cell_lymphoma	p.R941C (No)	GDSC	PI-103	0.0219
SIDM00377	UNCLASSIFIED\|uterus	p.H540R (No)	GDSC	PI-103	2.6284
SIDM00498	COREAD\|large_intestine	p.I603V (No)	GDSC	PI-103	3.2887
SIDM00793	UNCLASSIFIED\|Burkitt_lymphoma	p.A624V (No)	GDSC	PI-103	0.0783
SIDM01045	UCEC\|endometrium	p.V94E (No)	GDSC	PI-103	3.7811
SIDM00946	ALL\|T_cell_leukemia	p.V50M (No)	GDSC	PI-103	0.526
SIDM00864	CESC\|cervix	p.I875V (No)	GDSC	PI-103	23.1182
SIDM00523	SCLC\|lung_small_cell_carcinoma	p.R433S (No)	GDSC	PI-103	131.0205
SIDM00217	COREAD\|large_intestine	p.A1178V (No)	GDSC	PI-103	1.8634
SIDM00217	COREAD\|large_intestine	p.E896K (No)	GDSC	PI-103	1.8634
SIDM01003	ALL\|lymphoblastic_leukemia	p.R497Q (No)	GDSC	PI-103	0.2158
SIDM00216	COREAD\|large_intestine	p.I146T (No)	GDSC	PI-103	20.9452
SIDM00596	UCEC\|endometrium	p.R498Q (No)	GDSC	PI-103	22.6646
SIDM00282	COREAD\|large_intestine	p.A719S (No)	GDSC	PI-103	28.6572
SIDM00660	COREAD\|large_intestine	p.A512V (No)	GDSC	PI-103	0.5852
SIDM00955	SKCM\|melanoma	p.T1022N (No)	GDSC	PI-103	14.8056
SIDM00783	COREAD\|large_intestine	p.R792W (No)	GDSC	PI-103	0.5867
SIDM00845	UNCLASSIFIED\|Burkitt_lymphoma	p.I33V (No)	GDSC	PI-103	0.0974
SIDM00789	COREAD\|large_intestine	p.V67I (No)	GDSC	PI-103	0.8427
SIDM00534	COREAD\|large_intestine	p.V1121A (No)	GDSC	PI-103	137.3337
SIDM00149	SKCM\|melanoma	p.M635I (No)	GDSC	PI-103	3.9173
SIDM00545	SKCM\|melanoma	p.R1056Q (No)	GDSC	PI-103	9.7833
SIDM00545	SKCM\|melanoma	p.H524Y (No)	GDSC	PI-103	9.7833
SIDM00114	MESO\|mesothelioma	p.L716I (No)	GDSC	PI-103	6.8017
SIDM01154	ALL\|lymphoblastic_T_cell_leukaemia	p.R133H (No)	GDSC	PI-103	0.976
SIDM00451	ALL\|lymphoblastic_T_cell_leukaemia	p.L108F (No)	GDSC	PI-103	0.2536
SIDM00339	LUAD\|lung_NSCLC_adenocarcinoma	p.S317I (No)	GDSC	PI-103	17.6642
SIDM01018	UNCLASSIFIED\|Hodgkin_lymphoma	p.F500V (No)	GDSC	PI-103	1.0649
SIDM01018	UNCLASSIFIED\|Hodgkin_lymphoma	p.Y468N (No)	GDSC	PI-103	1.0649
SIDM00537	COREAD\|large_intestine	p.T125A (No)	GDSC	PI-103	32.6383
SIDM00799	GBM\|glioma	p.S1002Y (Yes)	GDSC	PI-103	54.1746
SIDM00496	THCA\|thyroid	p.Q747K (No)	GDSC	PI-103	0.4742
SIDM00878	BRCA\|breast	p.R833C (No)	GDSC	PI-103	0.1835

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A1A519	Protein FAM170A	DEG_SPOP_SBC_1	51:55	VTSTS	SPOP	0.8827	More...
O75475	PC4 and SFRS1-interacting protein	DEG_SPOP_SBC_1	269:273	VTSTS	SPOP	0.9904	More...
P35638	DNA damage-inducible transcript 3 protein	DEG_SPOP_SBC_1	73:77	VTSTS	SPOP	0.8287	More...
Q01546	Keratin, type II cytoskeletal 2 oral	DEG_SPOP_SBC_1	512:516	VTSTS	SPOP	0.6377	More...
Q02505	Mucin-3A	DEG_SPOP_SBC_1	804:808	VTSTS	SPOP	0.8927	More...
Q02505	Mucin-3A	DEG_SPOP_SBC_1	1557:1561	VTSTS	SPOP	0.8949	More...
Q14966	Zinc finger protein 638	DEG_SPOP_SBC_1	787:791	VTSTS	SPOP	0.9967	More...
Q6W4X9	Mucin-6	DEG_SPOP_SBC_1	1761:1765	VTSTS	SPOP	0.5627	More...
Q7Z7A1	Centriolin	DEG_SPOP_SBC_1	2288:2292	VTSTS	SPOP	0.8742	More...
Q8IZF6	Adhesion G-protein coupled receptor G4	DEG_SPOP_SBC_1	1248:1252	VTSTS	SPOP	0.959	More...
Q8TCU4	Alstrom syndrome protein 1	DEG_SPOP_SBC_1	1139:1143	VTSTS	SPOP	0.9584	More...
Q8TCU4	Alstrom syndrome protein 1	DEG_SPOP_SBC_1	1376:1380	VTSTS	SPOP	0.995	More...
Q8TCU4	Alstrom syndrome protein 1	DEG_SPOP_SBC_1	1801:1805	VTSTS	SPOP	0.9919	More...
Q96T58	Msx2-interacting protein	DEG_SPOP_SBC_1	2549:2553	VTSTS	SPOP	0.9158	More...
Q9H2X6	Homeodomain-interacting protein kinase 2	DEG_SPOP_SBC_1	1006:1010	VTSTS	SPOP	0.8996	More...
Q8NET4	Retrotransposon Gag-like protein 9	DEG_SPOP_SBC_1	870:874	VTSTS	SPOP	0.9347	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VTSTS

Degron related mutations and impact score

Drug responses associated with HIPK2 mutations

All proteins holding degron of VTSTS