DegronMD

Uniprot ID: Q8TCU4

Source protein: Alstrom syndrome protein 1

Source gene: ALMS1

Class: DEG_SCF_FBW7_1

Location: 3910:3915

E3 ligase: FBXW7

DEGRON score: 0.9421

ASA_SCORE: 60.4667

COIL: 0.8648

CONS_SCORE: 0.5134

DSS_SCORE: 0.5498

HELIX: 0.0613

FCONS_SCORE: 0.9845

RIG_SCORE: 0.6632

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T3901I	TCGA-34-2600	LUSC	TCGA	PTPSSS	DEG_SCF_FBW7_1	0.0833
p.T3901I	DO27081	LUSC	ICGC	PTPSSS	DEG_SCF_FBW7_1	0.0833
p.S3914I	TCGA-B5-A1MY	UCEC	TCGA	PTPSSS	DEG_SCF_FBW7_1	0.623
p.R3902Q	TCGA-B5-A3FA	UCEC	TCGA	PTPSSS	DEG_SCF_FBW7_1	0.1111
p.E3920A	TCGA-BS-A0UA	UCEC	TCGA	PTPSSS	DEG_SCF_FBW7_1	0.1944
p.P3911L	TCGA-D3-A8GN	SKCM	TCGA	PTPSSS	DEG_SCF_FBW7_1	0.7582
p.P3911L	DO51240	SKCM	ICGC	PTPSSS	DEG_SCF_FBW7_1	0.7582
p.S3922R	TCGA-EY-A215	UCEC	TCGA	PTPSSS	DEG_SCF_FBW7_1	0.1389
p.R3903I	DO228944	LICA	ICGC	PTPSSS	DEG_SCF_FBW7_1	0.1389
p.S3912A	DO229268	THCA	ICGC	PTPSSS	DEG_SCF_FBW7_1	0.7588
p.V3916A	DO50078	UCEC	ICGC	PTPSSS	DEG_SCF_FBW7_1	0.3056
p.N3922D	SIDM00951	T-Lymphoblastic Leukemia	GDSC	PTPSSS	DEG_SCF_FBW7_1	0.1389
p.N3922D	CTV-1	haematopoietic_and_lymphoid_tissue	COSMIC	PTPSSS	DEG_SCF_FBW7_1	0.1389
p.T3925P	ACH-002278	Neuroblastoma	CCLE	PTPSSS	DEG_SCF_FBW7_1	0.0556
p.V3921A	LNCaP-Clone-FGC	prostate	COSMIC	PTPSSS	DEG_SCF_FBW7_1	0.1667
p.S3913A	KYSE-450	oesophagus	COSMIC	PTPSSS	DEG_SCF_FBW7_1	0.6477

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P61964	WD repeat-containing protein 5	DEG_SCF_FBW7_1	17:22	PTPSSS	FBXW7	0.8022	More...
Q8TCU4	Alstrom syndrome protein 1	DEG_SCF_FBW7_1	3910:3915	PTPSSS	FBXW7	0.9421	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons