DegronMD

Uniprot ID: P61964

Source protein: WD repeat-containing protein 5

Source gene: WDR5

Class: DEG_SCF_FBW7_1

Location: 17:22

E3 ligase: FBXW7

DEGRON score: 0.8022

ASA_SCORE: 57.1

COIL: 0.8275

CONS_SCORE: 0.4832

DSS_SCORE: 0.7472

HELIX: 0.1007

FCONS_SCORE: 1.0783

RIG_SCORE: 0.5548

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E9D	TCGA-DQ-7591	HNSC	TCGA	PTPSSS	DEG_SCF_FBW7_1	0.5556
p.E9D	DO16007	HNSC	ICGC	PTPSSS	DEG_SCF_FBW7_1	0.5556
p.P19H	TCGA-EE-A2MG	SKCM	TCGA	PTPSSS	DEG_SCF_FBW7_1	0.7694
p.P19H	DO37421	SKCM	ICGC	PTPSSS	DEG_SCF_FBW7_1	0.7694
p.E9K	TCGA-EO-A22U	UCEC	TCGA	PTPSSS	DEG_SCF_FBW7_1	0.5556
p.E9K	DO43755	UCEC	ICGC	PTPSSS	DEG_SCF_FBW7_1	0.5556
p.S20L	DO234197	ESAD	ICGC	PTPSSS	DEG_SCF_FBW7_1	0.6556
p.A23S	DO228976	LICA	ICGC	PTPSSS	DEG_SCF_FBW7_1	0.3056
p.A23S	DO228985	LICA	ICGC	PTPSSS	DEG_SCF_FBW7_1	0.3056
p.S21L	DO231766	LINC	ICGC	PTPSSS	DEG_SCF_FBW7_1	0.6556
p.A13T	DO232623	PBCA	ICGC	PTPSSS	DEG_SCF_FBW7_1	0.2222
p.T18P	DO219881	SKCA	ICGC	PTPSSS	DEG_SCF_FBW7_1	0.8142
p.T18P	DO229453	SKCA	ICGC	PTPSSS	DEG_SCF_FBW7_1	0.8142
p.T18P	DO227681	SKCA	ICGC	PTPSSS	DEG_SCF_FBW7_1	0.8142
p.A23T	DO229544	UTCA	ICGC	PTPSSS	DEG_SCF_FBW7_1	0.3056
p.T18A	SIDM00364	B-Lymphoblastic Leukemia	GDSC	PTPSSS	DEG_SCF_FBW7_1	0.825
p.T18A	ACH-002059	Leukemia	CCLE	PTPSSS	DEG_SCF_FBW7_1	0.825
p.T18A	P30-OHK	haematopoietic_and_lymphoid_tissue	COSMIC	PTPSSS	DEG_SCF_FBW7_1	0.825
p.E11D	OAW-28	ovary	COSMIC	PTPSSS	DEG_SCF_FBW7_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P61964	WD repeat-containing protein 5	DEG_SCF_FBW7_1	17:22	PTPSSS	FBXW7	0.8022	More...
Q8TCU4	Alstrom syndrome protein 1	DEG_SCF_FBW7_1	3910:3915	PTPSSS	FBXW7	0.9421	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons