DegronMD - P61964(WDR5)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E9D	TCGA-DQ-7591	HNSC	TCGA	PTPSSS	DEG_SCF_FBW7_1	17:22	Mutation blocking phosphorylation signal	0.5556
p.E9D	DO16007	HNSC	ICGC	PTPSSS	DEG_SCF_FBW7_1	17:22	Mutation blocking phosphorylation signal	0.5556
p.P19H	TCGA-EE-A2MG	SKCM	TCGA	PTPSSS	DEG_SCF_FBW7_1	17:22	Mutation altering degron motif	0.7694
p.P19H	DO37421	SKCM	ICGC	PTPSSS	DEG_SCF_FBW7_1	17:22	Mutation altering degron motif	0.7694
p.E9K	TCGA-EO-A22U	UCEC	TCGA	PTPSSS	DEG_SCF_FBW7_1	17:22	Mutation blocking phosphorylation signal	0.5556
p.E9K	DO43755	UCEC	ICGC	PTPSSS	DEG_SCF_FBW7_1	17:22	Mutation blocking phosphorylation signal	0.5556
p.S20L	DO234197	ESAD	ICGC	PTPSSS	DEG_SCF_FBW7_1	17:22	Mutation altering degron motif	0.6556
p.A23S	DO228976	LICA	ICGC	PTPSSS	DEG_SCF_FBW7_1	17:22	Mutation rewiring degron network	0.3056
p.A23S	DO228985	LICA	ICGC	PTPSSS	DEG_SCF_FBW7_1	17:22	Mutation rewiring degron network	0.3056
p.S21L	DO231766	LINC	ICGC	PTPSSS	DEG_SCF_FBW7_1	17:22	Mutation altering degron motif	0.6556
p.A13T	DO232623	PBCA	ICGC	PTPSSS	DEG_SCF_FBW7_1	17:22	Mutation rewiring degron network	0.2222
p.T18P	DO219881	SKCA	ICGC	PTPSSS	DEG_SCF_FBW7_1	17:22	Mutation altering degron motif	0.8142
p.T18P	DO229453	SKCA	ICGC	PTPSSS	DEG_SCF_FBW7_1	17:22	Mutation altering degron motif	0.8142
p.T18P	DO227681	SKCA	ICGC	PTPSSS	DEG_SCF_FBW7_1	17:22	Mutation altering degron motif	0.8142
p.A23T	DO229544	UTCA	ICGC	PTPSSS	DEG_SCF_FBW7_1	17:22	Mutation rewiring degron network	0.3056
p.T18A	SIDM00364	B-Lymphoblastic Leukemia	GDSC	PTPSSS	DEG_SCF_FBW7_1	17:22	Mutation altering degron motif	0.825
p.T18A	ACH-002059	Leukemia	CCLE	PTPSSS	DEG_SCF_FBW7_1	17:22	Mutation altering degron motif	0.825
p.T18A	P30-OHK	haematopoietic and lymphoid tissue	COSMIC	PTPSSS	DEG_SCF_FBW7_1	17:22	Mutation altering degron motif	0.825
p.E11D	OAW-28	ovary	COSMIC	PTPSSS	DEG_SCF_FBW7_1	17:22	Mutation rewiring degron network	0.1667

Kaplan plot for WDR5 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

WDR5

UniProt ID: P61964

Entrez ID: 11091

Protein name: WD repeat-containing protein 5 (BMP2-induced 3-kb gene protein)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for WDR5 in