DegronMD

Uniprot ID: Q8TCU4

Source protein: Alstrom syndrome protein 1

Source gene: ALMS1

Class: DEG_SCF_FBW7_1

Location: 497:504

E3 ligase: FBXW7

DEGRON score: 0.9715

ASA_SCORE: 84.4

COIL: 0.8534

CONS_SCORE: 0.2738

DSS_SCORE: 0.4296

HELIX: 0.0234

FCONS_SCORE: 1

RIG_SCORE: 0.7403

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D505A	TCGA-CN-A63T	HNSC	TCGA	ITTTPVDS	DEG_SCF_FBW7_1	0.3056
p.D505A	DO49040	HNSC	ICGC	ITTTPVDS	DEG_SCF_FBW7_1	0.3056
p.S495L	TCGA-FU-A3HY	CESC	TCGA	ITTTPVDS	DEG_SCF_FBW7_1	0.2778
p.T489A	DO233764	GACA	ICGC	ITTTPVDS	DEG_SCF_FBW7_1	0.1111
p.S511F	SIDM00140	Melanoma	GDSC	ITTTPVDS	DEG_SCF_FBW7_1	0.5833
p.S511F	ACH-000968	Skin Cancer	CCLE	ITTTPVDS	DEG_SCF_FBW7_1	0.5833
p.H509Y	ACH-001413	Bladder Cancer	CCLE	ITTTPVDS	DEG_SCF_FBW7_1	0.1944
p.T503I	NCI-H727	lung	COSMIC	ITTTPVDS	DEG_SCF_FBW7_1	0.7078

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8TCU4	Alstrom syndrome protein 1	DEG_SCF_FBW7_1	497:504	ITTTPVDS	FBXW7	0.9715	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons