DegronMD

Uniprot ID: Q8TCU4

Source protein: Alstrom syndrome protein 1

Source gene: ALMS1

Class: DEG_APCC_DBOX_1

Location: 4075:4083

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5316

ASA_SCORE: 93.9444

COIL: 0.4593

CONS_SCORE: 0.4806

DSS_SCORE: 0.4007

HELIX: 0.5326

FCONS_SCORE: 1.1513

RIG_SCORE: 0.8093

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R4085W	TCGA-A5-A0G2	UCEC	TCGA	ERDALFNID	DEG_APCC_DBOX_1	0.2778
p.R4075W	TCGA-CG-4460	STAD	TCGA	ERDALFNID	DEG_APCC_DBOX_1	0.8634
p.R4075W	DO38427	STAD	ICGC	ERDALFNID	DEG_APCC_DBOX_1	0.8634
p.R4091C	TCGA-D3-A51G	SKCM	TCGA	ERDALFNID	DEG_APCC_DBOX_1	0.1111
p.R4091C	DO47700	SKCM	ICGC	ERDALFNID	DEG_APCC_DBOX_1	0.1111
p.D4082Y	TCGA-E7-A541	BLCA	TCGA	ERDALFNID	DEG_APCC_DBOX_1	0.7325
p.R4083K	TCGA-EB-A97M	SKCM	TCGA	ERDALFNID	DEG_APCC_DBOX_1	0.7237
p.R4075L	TCGA-EE-A2GL	SKCM	TCGA	ERDALFNID	DEG_APCC_DBOX_1	0.8428
p.R4075L	DO37434	SKCM	ICGC	ERDALFNID	DEG_APCC_DBOX_1	0.8428
p.E4084K	TCGA-YD-A89C	SKCM	TCGA	ERDALFNID	DEG_APCC_DBOX_1	0.3056
p.F4079L	DO48448	BLCA	ICGC	ERDALFNID	DEG_APCC_DBOX_1	0.6981
p.S4076F	DO52087	HNSC	ICGC	ERDALFNID	DEG_APCC_DBOX_1	0.7982
p.Q4082H	DO229019	LICA	ICGC	ERDALFNID	DEG_APCC_DBOX_1	0.7582
p.K4069R	DO23228	LINC	ICGC	ERDALFNID	DEG_APCC_DBOX_1	0.1667
p.P4066L	DO24702	LUAD	ICGC	ERDALFNID	DEG_APCC_DBOX_1	0.0833
p.I4067M	DO24702	LUAD	ICGC	ERDALFNID	DEG_APCC_DBOX_1	0.5556
p.K4077T	DO42745	UCEC	ICGC	ERDALFNID	DEG_APCC_DBOX_1	0.7306
p.R4092H	SIDM00217	Colorectal Carcinoma	GDSC	ERDALFNID	DEG_APCC_DBOX_1	0.0833
p.R4092H	SNU-1040	large_intestine	COSMIC	ERDALFNID	DEG_APCC_DBOX_1	0.0833
p.E4074K	ACH-000328	Brain Cancer	CCLE	ERDALFNID	DEG_APCC_DBOX_1	0.3056
p.A4077V	ACH-000937	Leukemia	CCLE	ERDALFNID	DEG_APCC_DBOX_1	0.6936
p.Q4075R	SR	haematopoietic_and_lymphoid_tissue	COSMIC	ERDALFNID	DEG_APCC_DBOX_1	0.7329
p.Q4075R	BT-474	breast	COSMIC	ERDALFNID	DEG_APCC_DBOX_1	0.7329
p.Q4075R	HT-115	large_intestine	COSMIC	ERDALFNID	DEG_APCC_DBOX_1	0.7329
p.M4073I	CCF-STTG1	central_nervous_system	COSMIC	ERDALFNID	DEG_APCC_DBOX_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8TCU4	Alstrom syndrome protein 1	DEG_APCC_DBOX_1	4075:4083	ERDALFNID	APC,CDC20,FZR1	0.5316	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: ERDALFNID

Degron related mutations and impact score

Drug responses associated with ALMS1 mutations

All proteins holding degron of ERDALFNID