DegronMD

Uniprot ID: Q8TCU4

Source protein: Alstrom syndrome protein 1

Source gene: ALMS1

Class: DEG_APCC_DBOX_1

Location: 3040:3048

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9669

ASA_SCORE: 82.8667

COIL: 0.5523

CONS_SCORE: 0.5912

DSS_SCORE: 0.2711

HELIX: 0.1544

FCONS_SCORE: 1.4371

RIG_SCORE: 0.7475

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P3052S	TCGA-UY-A9PD	BLCA	TCGA	NRKALSCVH	DEG_APCC_DBOX_1	0.2222
p.S3049W	DO219049	BLCA	ICGC	NRKALSCVH	DEG_APCC_DBOX_1	0.3056
p.A3030V	DO42280	UCEC	ICGC	NRKALSCVH	DEG_APCC_DBOX_1	0.0556
p.P3037R	SIDM00505	Pancreatic Carcinoma	GDSC	NRKALSCVH	DEG_APCC_DBOX_1	0.25
p.P3037R	MIA-PaCa-2	pancreas	COSMIC	NRKALSCVH	DEG_APCC_DBOX_1	0.25
p.P3036R	ACH-000601	Pancreatic Cancer	CCLE	NRKALSCVH	DEG_APCC_DBOX_1	0.6667
p.H3047R	ACH-000786	Lymphoma	CCLE	NRKALSCVH	DEG_APCC_DBOX_1	0.8244

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8TCU4	Alstrom syndrome protein 1	DEG_APCC_DBOX_1	3040:3048	NRKALSCVH	APC,CDC20,FZR1	0.9669	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons