DegronMD

Uniprot ID: Q9C0F0

Source protein: Putative Polycomb group protein ASXL3

Source gene: ASXL3

Class: DEG_ODPH_VHL_1

Location: 492:505

E3 ligase: VHL

DEGRON score: 0.7533

ASA_SCORE: 87.6

COIL: 0.7241

CONS_SCORE: 0.3169

DSS_SCORE: 0.6086

HELIX: 0.2125

FCONS_SCORE: 1.0076

RIG_SCORE: 0.7216

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E510D	TCGA-43-8118	LUSC	TCGA	IAPPEDNLESCVMM	DEG_ODPH_VHL_1	0.1944
p.E510D	DO45471	LUSC	ICGC	IAPPEDNLESCVMM	DEG_ODPH_VHL_1	0.1944
p.V503G	TCGA-AX-A2HC	UCEC	TCGA	IAPPEDNLESCVMM	DEG_ODPH_VHL_1	0.7532
p.V503G	DO41572	UCEC	ICGC	IAPPEDNLESCVMM	DEG_ODPH_VHL_1	0.7532
p.D507Y	TCGA-B5-A11E	UCEC	TCGA	IAPPEDNLESCVMM	DEG_ODPH_VHL_1	0.2778
p.D507Y	DO41644	UCEC	ICGC	IAPPEDNLESCVMM	DEG_ODPH_VHL_1	0.2778
p.M505I	TCGA-D3-A8GQ	SKCM	TCGA	IAPPEDNLESCVMM	DEG_ODPH_VHL_1	0.6507
p.M505I	DO51246	SKCM	ICGC	IAPPEDNLESCVMM	DEG_ODPH_VHL_1	0.6507
p.T484P	TCGA-D8-A27H	BRCA	TCGA	IAPPEDNLESCVMM	DEG_ODPH_VHL_1	0.1111
p.T484P	DO1249	BRCA	ICGC	IAPPEDNLESCVMM	DEG_ODPH_VHL_1	0.1111
p.M505L	TCGA-EB-A97M	SKCM	TCGA	IAPPEDNLESCVMM	DEG_ODPH_VHL_1	0.5999
p.M505L	DO50298	SKCM	ICGC	IAPPEDNLESCVMM	DEG_ODPH_VHL_1	0.5999
p.E496K	TCGA-ER-A19F	SKCM	TCGA	IAPPEDNLESCVMM	DEG_ODPH_VHL_1	0.591
p.E496K	DO37679	SKCM	ICGC	IAPPEDNLESCVMM	DEG_ODPH_VHL_1	0.591
p.L512S	TCGA-NC-A5HO	LUSC	TCGA	IAPPEDNLESCVMM	DEG_ODPH_VHL_1	0.1389
p.L512S	DO219197	LUSC	ICGC	IAPPEDNLESCVMM	DEG_ODPH_VHL_1	0.1389
p.S482I	TCGA-UT-A97Y	MESO	TCGA	IAPPEDNLESCVMM	DEG_ODPH_VHL_1	0.0556
p.M504I	TCGA-Z2-A8RT	SKCM	TCGA	IAPPEDNLESCVMM	DEG_ODPH_VHL_1	0.6507
p.M504I	DO51301	SKCM	ICGC	IAPPEDNLESCVMM	DEG_ODPH_VHL_1	0.6507
p.V503L	TCGA-ZJ-AB0H	CESC	TCGA	IAPPEDNLESCVMM	DEG_ODPH_VHL_1	0.5654
p.V503L	DO219760	CESC	ICGC	IAPPEDNLESCVMM	DEG_ODPH_VHL_1	0.5654
p.I515V	DO23108	LINC	ICGC	IAPPEDNLESCVMM	DEG_ODPH_VHL_1	0.0556
p.S486F	DO36556	READ	ICGC	IAPPEDNLESCVMM	DEG_ODPH_VHL_1	0.1667
p.E488K	DO41398	UCEC	ICGC	IAPPEDNLESCVMM	DEG_ODPH_VHL_1	0.2222
p.H487Y	SIDM01161	Other Sarcomas	GDSC	IAPPEDNLESCVMM	DEG_ODPH_VHL_1	0.1944
p.H487Y	ACH-001274	Sarcoma	CCLE	IAPPEDNLESCVMM	DEG_ODPH_VHL_1	0.1944
p.H487Y	SW982	soft_tissue	COSMIC	IAPPEDNLESCVMM	DEG_ODPH_VHL_1	0.1944
p.M505T	ACH-001750	Sarcoma	CCLE	IAPPEDNLESCVMM	DEG_ODPH_VHL_1	0.7423

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: IAPPEDNLESCVMM

Degron related mutations and impact score

Drug responses associated with ASXL3 mutations

All proteins holding degron of IAPPEDNLESCVMM

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9C0F0	Putative Polycomb group protein ASXL3	DEG_ODPH_VHL_1	492:505	IAPPEDNLESCVMM	VHL	0.7533	More...