DegronMD

Uniprot ID: Q68DK2

Source protein: Zinc finger FYVE domain-containing protein 26

Source gene: ZFYVE26

Class: DEG_SCF_FBW7_1

Location: 1103:1109

E3 ligase: FBXW7

DEGRON score: 0.7313

ASA_SCORE: 82.9429

COIL: 0.8936

CONS_SCORE: 0.2992

DSS_SCORE: 0.578

HELIX: 0.078

FCONS_SCORE: 0.9699

RIG_SCORE: 0.6401

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q1117K	TCGA-D3-A2JN	SKCM	TCGA	PRTPPLS	DEG_SCF_FBW7_1	0.1111
p.Q1117K	DO47590	SKCM	ICGC	PRTPPLS	DEG_SCF_FBW7_1	0.1111
p.A1097V	TCGA-DU-6392	LGG	TCGA	PRTPPLS	DEG_SCF_FBW7_1	0.1667
p.A1097V	DO22237	LGG	ICGC	PRTPPLS	DEG_SCF_FBW7_1	0.1667
p.A1115T	TCGA-FI-A2D5	UCEC	TCGA	PRTPPLS	DEG_SCF_FBW7_1	0.1667
p.A1115T	DO41331	UCEC	ICGC	PRTPPLS	DEG_SCF_FBW7_1	0.1667
p.P1106S	TCGA-FR-A726	SKCM	TCGA	PRTPPLS	DEG_SCF_FBW7_1	0.6752
p.P1106S	DO48665	SKCM	ICGC	PRTPPLS	DEG_SCF_FBW7_1	0.6752
p.P1103L	DO229003	COCA	ICGC	PRTPPLS	DEG_SCF_FBW7_1	0.6471
p.P1103L	DO223144	ESCA	ICGC	PRTPPLS	DEG_SCF_FBW7_1	0.6471
p.P1103L	DO230659	LAML	ICGC	PRTPPLS	DEG_SCF_FBW7_1	0.6471
p.P1103L	DO52365	LUSC	ICGC	PRTPPLS	DEG_SCF_FBW7_1	0.6471
p.S1110F	DO220899	MELA	ICGC	PRTPPLS	DEG_SCF_FBW7_1	0.3056
p.R1104M	DO229240	THCA	ICGC	PRTPPLS	DEG_SCF_FBW7_1	0.7521

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q68DK2	Zinc finger FYVE domain-containing protein 26	DEG_SCF_FBW7_1	1103:1109	PRTPPLS	FBXW7	0.7313	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons