DegronMD

Uniprot ID: Q68DK2

Source protein: Zinc finger FYVE domain-containing protein 26

Source gene: ZFYVE26

Class: DEG_APCC_DBOX_1

Location: 905:913

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9605

ASA_SCORE: 61.2444

COIL: 0.4951

CONS_SCORE: 0.3785

DSS_SCORE: 0.363

HELIX: 0.4533

FCONS_SCORE: 1.0127

RIG_SCORE: 0.7265

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q910H	TCGA-37-4130	LUSC	TCGA	GRSTLQAIG	DEG_APCC_DBOX_1	0.647
p.Q910H	DO26490	LUSC	ICGC	GRSTLQAIG	DEG_APCC_DBOX_1	0.647
p.Q910H	SIDM00839	Colorectal Carcinoma	GDSC	GRSTLQAIG	DEG_APCC_DBOX_1	0.647
p.Q910H	ACH-000950	Colon/Colorectal Cancer	CCLE	GRSTLQAIG	DEG_APCC_DBOX_1	0.647
p.Q910H	LoVo	large_intestine	COSMIC	GRSTLQAIG	DEG_APCC_DBOX_1	0.647
p.A915S	TCGA-55-A4DG	LUAD	TCGA	GRSTLQAIG	DEG_APCC_DBOX_1	0.2778
p.A915S	DO26337	LUAD	ICGC	GRSTLQAIG	DEG_APCC_DBOX_1	0.2778
p.G919R	TCGA-A5-A0G2	UCEC	TCGA	GRSTLQAIG	DEG_APCC_DBOX_1	0.1667
p.G919R	DO41235	UCEC	ICGC	GRSTLQAIG	DEG_APCC_DBOX_1	0.1667
p.Q910K	TCGA-A5-A0GM	UCEC	TCGA	GRSTLQAIG	DEG_APCC_DBOX_1	0.5833
p.Q910K	DO42737	UCEC	ICGC	GRSTLQAIG	DEG_APCC_DBOX_1	0.5833
p.R901I	TCGA-F5-6814	READ	TCGA	GRSTLQAIG	DEG_APCC_DBOX_1	0.2222
p.R901I	DO36556	READ	ICGC	GRSTLQAIG	DEG_APCC_DBOX_1	0.2222
p.A917V	TCGA-MN-A4N4	LUAD	TCGA	GRSTLQAIG	DEG_APCC_DBOX_1	0.2222
p.A917V	DO26250	LUAD	ICGC	GRSTLQAIG	DEG_APCC_DBOX_1	0.2222
p.R900W	TCGA-Z2-A8RT	SKCM	TCGA	GRSTLQAIG	DEG_APCC_DBOX_1	0.1944
p.R900W	DO51301	SKCM	ICGC	GRSTLQAIG	DEG_APCC_DBOX_1	0.1944
p.A916E	DO229045	LICA	ICGC	GRSTLQAIG	DEG_APCC_DBOX_1	0.25
p.A918V	DO229259	THCA	ICGC	GRSTLQAIG	DEG_APCC_DBOX_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q68DK2	Zinc finger FYVE domain-containing protein 26	DEG_APCC_DBOX_1	905:913	GRSTLQAIG	APC,CDC20,FZR1	0.9605	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons