DegronMD

Uniprot ID: Q9UGI9

Source protein: 5'-AMP-activated protein kinase subunit gamma-3

Source gene: PRKAG3

Class: DEG_SCF_FBW7_1

Location: 9:16

E3 ligase: FBXW7

DEGRON score: 0.8635

ASA_SCORE: 82.8125

COIL: 0.8021

CONS_SCORE: 0.2216

DSS_SCORE: 0.5766

HELIX: 0.1274

FCONS_SCORE: 1.1062

RIG_SCORE: 0.6718

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A8T	TCGA-CD-A4MI	STAD	TCGA	LRRTPSWS	DEG_SCF_FBW7_1	0.3056
p.A8T	DO47717	STAD	ICGC	LRRTPSWS	DEG_SCF_FBW7_1	0.3056
p.R10H	TCGA-D1-A103	UCEC	TCGA	LRRTPSWS	DEG_SCF_FBW7_1	0.7133
p.R10H	DO42312	UCEC	ICGC	LRRTPSWS	DEG_SCF_FBW7_1	0.7133
p.G20S	TCGA-EE-A2A2	SKCM	TCGA	LRRTPSWS	DEG_SCF_FBW7_1	0.2222
p.G20S	TCGA-ER-A1A1	SKCM	TCGA	LRRTPSWS	DEG_SCF_FBW7_1	0.2222
p.G20S	DO37583	SKCM	ICGC	LRRTPSWS	DEG_SCF_FBW7_1	0.2222
p.G20S	DO37413	SKCM	ICGC	LRRTPSWS	DEG_SCF_FBW7_1	0.2222
p.L18I	DO48429	BLCA	ICGC	LRRTPSWS	DEG_SCF_FBW7_1	0.2778
p.T12N	DO228985	LICA	ICGC	LRRTPSWS	DEG_SCF_FBW7_1	0.7055
p.A12D	DO231102	LUSC	ICGC	LRRTPSWS	DEG_SCF_FBW7_1	0.7793
p.S17Y	DO26701	LUSC	ICGC	LRRTPSWS	DEG_SCF_FBW7_1	0.3056
p.E6Q	DO232858	NACA	ICGC	LRRTPSWS	DEG_SCF_FBW7_1	0.25
p.M26I	DO46792	PRAD	ICGC	LRRTPSWS	DEG_SCF_FBW7_1	0.0556
p.Q5H	DO228014	SKCA	ICGC	LRRTPSWS	DEG_SCF_FBW7_1	0.2222
p.E6K	DO228014	SKCA	ICGC	LRRTPSWS	DEG_SCF_FBW7_1	0.25
p.G20A	SIDM00455	Pancreatic Carcinoma	GDSC	LRRTPSWS	DEG_SCF_FBW7_1	0.2222
p.G20A	ACH-000599	Pancreatic Cancer	CCLE	LRRTPSWS	DEG_SCF_FBW7_1	0.2222
p.G20A	PA-TU-8902	pancreas	COSMIC	LRRTPSWS	DEG_SCF_FBW7_1	0.2222
p.L9M	SIDM00942	Oral Cavity Carcinoma	GDSC	LRRTPSWS	DEG_SCF_FBW7_1	0.5999
p.L9M	ACH-000518	Head and Neck Cancer	CCLE	LRRTPSWS	DEG_SCF_FBW7_1	0.5999
p.L9M	CAL-33	upper_aerodigestive_tract	COSMIC	LRRTPSWS	DEG_SCF_FBW7_1	0.5999

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UGI9	5'-AMP-activated protein kinase subunit gamma-3	DEG_SCF_FBW7_1	9:16	LRRTPSWS	FBXW7	0.8635	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons