DegronMD

Uniprot ID: Q02952

Source protein: A-kinase anchor protein 12

Source gene: AKAP12

Class: DEG_COP1_1

Location: 1024:1032

E3 ligase: COP1

DEGRON score: 0.622

ASA_SCORE: 84.7

COIL: 0.8438

CONS_SCORE: 0.4727

DSS_SCORE: 0.7372

HELIX: 0.0904

FCONS_SCORE: 0.6099

RIG_SCORE: 0.6917

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R1038L	TCGA-18-3416	LUSC	TCGA	EVEGGVPDI	DEG_COP1_1	0.1667
p.V1029I	TCGA-AA-3821	COAD	TCGA	EVEGGVPDI	DEG_COP1_1	0.7076
p.P1021L	TCGA-EO-A22U	UCEC	TCGA	EVEGGVPDI	DEG_COP1_1	0.25
p.E1037K	DO22237	LGG	ICGC	EVEGGVPDI	DEG_COP1_1	0.1944
p.E1037K	DO41020	UCEC	ICGC	EVEGGVPDI	DEG_COP1_1	0.1944
p.E1033Q	DO23678	LUAD	ICGC	EVEGGVPDI	DEG_COP1_1	0.3056
p.P1026L	DO220878	MELA	ICGC	EVEGGVPDI	DEG_COP1_1	0.7582
p.E1023D	DO37643	SKCM	ICGC	EVEGGVPDI	DEG_COP1_1	0.3056
p.P1019H	DO37491	SKCM	ICGC	EVEGGVPDI	DEG_COP1_1	0.1944
p.T1039A	DO41379	UCEC	ICGC	EVEGGVPDI	DEG_COP1_1	0.5833
p.Q1040L	SIDM00935	Other Solid Cancers	GDSC	EVEGGVPDI	DEG_COP1_1	0.1111
p.Q1040L	CAL-39	vulva	COSMIC	EVEGGVPDI	DEG_COP1_1	0.1111
p.R1038W	SIDM00482	Chronic Myelogenous Leukemia	GDSC	EVEGGVPDI	DEG_COP1_1	0.1667
p.R1038W	SIDM01229	Neuroblastoma	GDSC	EVEGGVPDI	DEG_COP1_1	0.1667
p.T1039I	SIDM00516	Melanoma	GDSC	EVEGGVPDI	DEG_COP1_1	0.5833
p.T1039I	ACH-002166	Skin Cancer	CCLE	EVEGGVPDI	DEG_COP1_1	0.5833
p.T1039I	MZ7-mel	skin	COSMIC	EVEGGVPDI	DEG_COP1_1	0.5833
p.R1038Q	SIDM01695	Acute Myeloid Leukemia	GDSC	EVEGGVPDI	DEG_COP1_1	0.1667
p.V1042I	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	EVEGGVPDI	DEG_COP1_1	0.0556
p.S1024N	KM12	large_intestine	COSMIC	EVEGGVPDI	DEG_COP1_1	0.7069
p.S1031N	KM12	large_intestine	COSMIC	EVEGGVPDI	DEG_COP1_1	0.7069

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q02952	A-kinase anchor protein 12	DEG_COP1_1	1024:1032	EVEGGVPDI	COP1	0.622	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons