DegronMD

Uniprot ID: Q9HAW4

Source protein: Claspin

Source gene: CLSPN

Class: DEG_APCC_DBOX_1

Location: 892:900

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9842

ASA_SCORE: 89.6

COIL: 0.7388

CONS_SCORE: 0.3618

DSS_SCORE: 0.4228

HELIX: 0.2167

FCONS_SCORE: 1.0011

RIG_SCORE: 0.7502

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L896F	TCGA-19-1385	GBM	TCGA	PRLPLASMD	DEG_APCC_DBOX_1	0.6981
p.D909G	TCGA-28-1760	GBM	TCGA	PRLPLASMD	DEG_APCC_DBOX_1	0.0833
p.Y887H	TCGA-44-6146	LUAD	TCGA	PRLPLASMD	DEG_APCC_DBOX_1	0.6389
p.R884M	TCGA-AP-A1DV	UCEC	TCGA	PRLPLASMD	DEG_APCC_DBOX_1	0.1111
p.R884M	DO43186	UCEC	ICGC	PRLPLASMD	DEG_APCC_DBOX_1	0.1111
p.P892L	TCGA-WE-A8ZT	SKCM	TCGA	PRLPLASMD	DEG_APCC_DBOX_1	0.6471
p.P892L	DO51290	SKCM	ICGC	PRLPLASMD	DEG_APCC_DBOX_1	0.6471
p.P892Q	DO8264	COAD	ICGC	PRLPLASMD	DEG_APCC_DBOX_1	0.5924
p.A889T	DO233840	GACA	ICGC	PRLPLASMD	DEG_APCC_DBOX_1	0.25
p.P909Q	DO229031	LICA	ICGC	PRLPLASMD	DEG_APCC_DBOX_1	0.0833
p.R884S	SIDM01959	Colorectal Carcinoma	GDSC	PRLPLASMD	DEG_APCC_DBOX_1	0.1111
p.P892T	SIDM01490	Small Cell Lung Carcinoma	GDSC	PRLPLASMD	DEG_APCC_DBOX_1	0.5919
p.P892T	SIDM00473	Oral Cavity Carcinoma	GDSC	PRLPLASMD	DEG_APCC_DBOX_1	0.5919
p.P892T	SIDM01483	Melanoma	GDSC	PRLPLASMD	DEG_APCC_DBOX_1	0.5919
p.P892T	SIDM00096	T-Cell Non-Hodgkin's Lymphoma	GDSC	PRLPLASMD	DEG_APCC_DBOX_1	0.5919
p.P892T	SIDM00082	Melanoma	GDSC	PRLPLASMD	DEG_APCC_DBOX_1	0.5919
p.P892T	SIDM01017	B-Lymphoblastic Leukemia	GDSC	PRLPLASMD	DEG_APCC_DBOX_1	0.5919
p.P892T	SIDM00631	Breast Carcinoma	GDSC	PRLPLASMD	DEG_APCC_DBOX_1	0.5919
p.P892T	SIDM00754	Non-Small Cell Lung Carcinoma	GDSC	PRLPLASMD	DEG_APCC_DBOX_1	0.5919
p.P892T	SIDM00414	Bladder Carcinoma	GDSC	PRLPLASMD	DEG_APCC_DBOX_1	0.5919
p.P892T	SIDM01191	Osteosarcoma	GDSC	PRLPLASMD	DEG_APCC_DBOX_1	0.5919
p.P892T	SIDM00056	Thyroid Gland Carcinoma	GDSC	PRLPLASMD	DEG_APCC_DBOX_1	0.5919
p.P892T	SIDM01615	Non-Small Cell Lung Carcinoma	GDSC	PRLPLASMD	DEG_APCC_DBOX_1	0.5919
p.P892T	SIDM01743	Melanoma	GDSC	PRLPLASMD	DEG_APCC_DBOX_1	0.5919

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9HAW4	Claspin	DEG_APCC_DBOX_1	892:900	PRLPLASMD	APC,CDC20,FZR1	0.9842	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PRLPLASMD

Degron related mutations and impact score

Drug responses associated with CLSPN mutations

All proteins holding degron of PRLPLASMD