DegronMD

Uniprot ID: Q9HAW4

Source protein: Claspin

Source gene: CLSPN

Class: LIG_APCC_ABBA_1

Location: 725:730

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9862

ASA_SCORE: 92.7833

COIL: 0.409

CONS_SCORE: 0.4653

DSS_SCORE: 0.3632

HELIX: 0.5033

FCONS_SCORE: 1.5182

RIG_SCORE: 0.8004

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L727R	TCGA-AX-A05Z	UCEC	TCGA	LLLFKD	LIG_APCC_ABBA_1	0.8428
p.S723Y	TCGA-AZ-4315	COAD	TCGA	LLLFKD	LIG_APCC_ABBA_1	0.7222
p.G736S	TCGA-B5-A3FA	UCEC	TCGA	LLLFKD	LIG_APCC_ABBA_1	0.1667
p.Q728K	DO44037	BLCA	ICGC	LLLFKD	LIG_APCC_ABBA_1	0.6944
p.P737H	DO223703	COAD	ICGC	LLLFKD	LIG_APCC_ABBA_1	0.1389
p.P724T	DO229015	LICA	ICGC	LLLFKD	LIG_APCC_ABBA_1	0.75
p.S718Y	DO229035	LICA	ICGC	LLLFKD	LIG_APCC_ABBA_1	0.5833
p.A739S	DO51795	STAD	ICGC	LLLFKD	LIG_APCC_ABBA_1	0.0833
p.G732E	DO51761	STAD	ICGC	LLLFKD	LIG_APCC_ABBA_1	0.2778
p.G732V	DO41235	UCEC	ICGC	LLLFKD	LIG_APCC_ABBA_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96JH8	Ras-associating and dilute domain-containing protein	LIG_APCC_ABBA_1	352:357	LLLFKD	APC,CDC20,FZR1	0.7772	More...
Q9HAW4	Claspin	LIG_APCC_ABBA_1	725:730	LLLFKD	APC,CDC20,FZR1	0.9862	More...
Q9Y3C4	EKC/KEOPS complex subunit TPRKB	LIG_APCC_ABBA_1	17:22	LLLFKD	APC,CDC20,FZR1	0.6529	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons