DegronMD

Uniprot ID: Q9Y3C4

Source protein: EKC/KEOPS complex subunit TPRKB

Source gene: TPRKB

Class: LIG_APCC_ABBA_1

Location: 17:22

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6529

ASA_SCORE: 29.75

COIL: 0.285

CONS_SCORE: 0.6398

DSS_SCORE: 0.0623

HELIX: 0.0052

FCONS_SCORE: 1.3177

RIG_SCORE: 0.9375

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R14M	TCGA-HR-A2OG	SKCM	TCGA	LLLFKD	LIG_APCC_ABBA_1	0.25
p.R14M	DO37511	SKCM	ICGC	LLLFKD	LIG_APCC_ABBA_1	0.25
p.L9I	TCGA-VQ-A924	STAD	TCGA	LLLFKD	LIG_APCC_ABBA_1	0.1111
p.L9I	DO229026	LICA	ICGC	LLLFKD	LIG_APCC_ABBA_1	0.1111
p.L9I	DO51795	STAD	ICGC	LLLFKD	LIG_APCC_ABBA_1	0.1111
p.L9P	DO48410	BLCA	ICGC	LLLFKD	LIG_APCC_ABBA_1	0.1111
p.E12K	SIDM00358	Gastric Carcinoma	GDSC	LLLFKD	LIG_APCC_ABBA_1	0.1944
p.E12K	ACH-000144	Gastric Cancer	CCLE	LLLFKD	LIG_APCC_ABBA_1	0.1944
p.E12K	RERF-GC-1B	stomach	COSMIC	LLLFKD	LIG_APCC_ABBA_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96JH8	Ras-associating and dilute domain-containing protein	LIG_APCC_ABBA_1	352:357	LLLFKD	APC,CDC20,FZR1	0.7772	More...
Q9HAW4	Claspin	LIG_APCC_ABBA_1	725:730	LLLFKD	APC,CDC20,FZR1	0.9862	More...
Q9Y3C4	EKC/KEOPS complex subunit TPRKB	LIG_APCC_ABBA_1	17:22	LLLFKD	APC,CDC20,FZR1	0.6529	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons